Research ExplorerPublicationsMitochondrial mutations drive prostate cancer aggression

Mitochondrial mutations drive prostate cancer aggression

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Mitochondrial mutations drive prostate cancer aggression. / Hopkins, Julia F; Sabelnykova, Veronica Y; Weischenfeldt, Joachim; Simon, Ronald; Aguiar, Jennifer A; Alkallas, Rached; Heisler, Lawrence E; Zhang, Junyan; Watson, John D; Chua, Melvin L K; Fraser, Michael; Favero, Francesco; Lawerenz, Chris; Plass, Christoph; Sauter, Guido; McPherson, John D; van der Kwast, Theodorus; Korbel, Jan; Schlomm, Thorsten; Bristow, Robert G; Boutros, Paul C.

In: NAT COMMUN, Vol. 8, No. 1, 22.09.2017, p. 656.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hopkins, JF, Sabelnykova, VY, Weischenfeldt, J, Simon, R, Aguiar, JA, Alkallas, R, Heisler, LE, Zhang, J, Watson, JD, Chua, MLK, Fraser, M, Favero, F, Lawerenz, C, Plass, C, Sauter, G, McPherson, JD, van der Kwast, T, Korbel, J, Schlomm, T, Bristow, RG & Boutros, PC 2017, 'Mitochondrial mutations drive prostate cancer aggression', NAT COMMUN, vol. 8, no. 1, pp. 656. https://doi.org/10.1038/s41467-017-00377-y

APA

Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., van der Kwast, T., Korbel, J., Schlomm, T., ... Boutros, P. C. (2017). Mitochondrial mutations drive prostate cancer aggression. NAT COMMUN, 8(1), 656. https://doi.org/10.1038/s41467-017-00377-y

Vancouver

Hopkins JF, Sabelnykova VY, Weischenfeldt J, Simon R, Aguiar JA, Alkallas R et al. Mitochondrial mutations drive prostate cancer aggression. NAT COMMUN. 2017 Sep 22;8(1):656. https://doi.org/10.1038/s41467-017-00377-y

Bibtex

@article{df940be6cf884f1092c2027891b096f7,
title = "Mitochondrial mutations drive prostate cancer aggression",
abstract = "Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer.In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.",
keywords = "Journal Article",
author = "Hopkins, {Julia F} and Sabelnykova, {Veronica Y} and Joachim Weischenfeldt and Ronald Simon and Aguiar, {Jennifer A} and Rached Alkallas and Heisler, {Lawrence E} and Junyan Zhang and Watson, {John D} and Chua, {Melvin L K} and Michael Fraser and Francesco Favero and Chris Lawerenz and Christoph Plass and Guido Sauter and McPherson, {John D} and {van der Kwast}, Theodorus and Jan Korbel and Thorsten Schlomm and Bristow, {Robert G} and Boutros, {Paul C}",
year = "2017",
month = sep,
day = "22",
doi = "10.1038/s41467-017-00377-y",
language = "English",
volume = "8",
pages = "656",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Mitochondrial mutations drive prostate cancer aggression

AU - Hopkins, Julia F

AU - Sabelnykova, Veronica Y

AU - Weischenfeldt, Joachim

AU - Simon, Ronald

AU - Aguiar, Jennifer A

AU - Alkallas, Rached

AU - Heisler, Lawrence E

AU - Zhang, Junyan

AU - Watson, John D

AU - Chua, Melvin L K

AU - Fraser, Michael

AU - Favero, Francesco

AU - Lawerenz, Chris

AU - Plass, Christoph

AU - Sauter, Guido

AU - McPherson, John D

AU - van der Kwast, Theodorus

AU - Korbel, Jan

AU - Schlomm, Thorsten

AU - Bristow, Robert G

AU - Boutros, Paul C

PY - 2017/9/22

Y1 - 2017/9/22

N2 - Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer.In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

AB - Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer.In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

KW - Journal Article

U2 - 10.1038/s41467-017-00377-y

DO - 10.1038/s41467-017-00377-y

M3 - SCORING: Journal article

C2 - 28939825

VL - 8

SP - 656

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -