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miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

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miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. / Maegdefessel, Lars; Spin, Joshua M; Raaz, Uwe; Eken, Suzanne M; Toh, Ryuji; Azuma, Junya; Adam, Matti; Nakagami, Futoshi; Nagakami, Futoshi; Heymann, Helen M; Chernogubova, Ekaterina; Chernugobova, Ekaterina; Jin, Hong; Roy, Joy; Hultgren, Rebecka; Caidahl, Kenneth; Schrepfer, Sonja; Hamsten, Anders; Eriksson, Per; McConnell, Michael V; Dalman, Ronald L; Tsao, Philip S.

In: NAT COMMUN, Vol. 5, 31.10.2014, p. 5214.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Maegdefessel, L, Spin, JM, Raaz, U, Eken, SM, Toh, R, Azuma, J, Adam, M, Nakagami, F, Nagakami, F, Heymann, HM, Chernogubova, E, Chernugobova, E, Jin, H, Roy, J, Hultgren, R, Caidahl, K, Schrepfer, S, Hamsten, A, Eriksson, P, McConnell, MV, Dalman, RL & Tsao, PS 2014, 'miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development', NAT COMMUN, vol. 5, pp. 5214. https://doi.org/10.1038/ncomms6214

APA

Maegdefessel, L., Spin, J. M., Raaz, U., Eken, S. M., Toh, R., Azuma, J., Adam, M., Nakagami, F., Nagakami, F., Heymann, H. M., Chernogubova, E., Chernugobova, E., Jin, H., Roy, J., Hultgren, R., Caidahl, K., Schrepfer, S., Hamsten, A., Eriksson, P., ... Tsao, P. S. (2014). miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. NAT COMMUN, 5, 5214. https://doi.org/10.1038/ncomms6214

Vancouver

Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J et al. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. NAT COMMUN. 2014 Oct 31;5:5214. https://doi.org/10.1038/ncomms6214

Bibtex

@article{6d17044bc35f4810873de6d218edc247,
title = "miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development",
abstract = "Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of cardiovascular pathology and represent intriguing targets to limit AAA expansion. Here we show, by using two established murine models of AAA disease along with human aortic tissue and plasma analysis, that miR-24 is a key regulator of vascular inflammation and AAA pathology. In vivo and in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the control of miR-24, regulating cytokine synthesis in macrophages as well as their survival, promoting aortic smooth muscle cell migration and cytokine production, and stimulating adhesion molecule expression in vascular endothelial cells. We further show that modulation of miR-24 alters AAA progression in animal models, and that miR-24 and CHI3L1 represent novel plasma biomarkers of AAA disease progression in humans. ",
keywords = "Animals, Aorta/metabolism, Aortic Aneurysm, Abdominal/etiology, Biomarkers/blood, Cells, Cultured, Chitinase-3-Like Protein 1, Disease Models, Animal, Disease Progression, Endothelial Cells/metabolism, Glycoproteins/metabolism, Humans, Inflammation/metabolism, Macrophages/metabolism, Male, Mice, Mice, Inbred C57BL, MicroRNAs/metabolism, Myocytes, Smooth Muscle/metabolism",
author = "Lars Maegdefessel and Spin, {Joshua M} and Uwe Raaz and Eken, {Suzanne M} and Ryuji Toh and Junya Azuma and Matti Adam and Futoshi Nakagami and Futoshi Nagakami and Heymann, {Helen M} and Ekaterina Chernogubova and Ekaterina Chernugobova and Hong Jin and Joy Roy and Rebecka Hultgren and Kenneth Caidahl and Sonja Schrepfer and Anders Hamsten and Per Eriksson and McConnell, {Michael V} and Dalman, {Ronald L} and Tsao, {Philip S}",
year = "2014",
month = oct,
day = "31",
doi = "10.1038/ncomms6214",
language = "English",
volume = "5",
pages = "5214",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

AU - Maegdefessel, Lars

AU - Spin, Joshua M

AU - Raaz, Uwe

AU - Eken, Suzanne M

AU - Toh, Ryuji

AU - Azuma, Junya

AU - Adam, Matti

AU - Nakagami, Futoshi

AU - Nagakami, Futoshi

AU - Heymann, Helen M

AU - Chernogubova, Ekaterina

AU - Chernugobova, Ekaterina

AU - Jin, Hong

AU - Roy, Joy

AU - Hultgren, Rebecka

AU - Caidahl, Kenneth

AU - Schrepfer, Sonja

AU - Hamsten, Anders

AU - Eriksson, Per

AU - McConnell, Michael V

AU - Dalman, Ronald L

AU - Tsao, Philip S

PY - 2014/10/31

Y1 - 2014/10/31

N2 - Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of cardiovascular pathology and represent intriguing targets to limit AAA expansion. Here we show, by using two established murine models of AAA disease along with human aortic tissue and plasma analysis, that miR-24 is a key regulator of vascular inflammation and AAA pathology. In vivo and in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the control of miR-24, regulating cytokine synthesis in macrophages as well as their survival, promoting aortic smooth muscle cell migration and cytokine production, and stimulating adhesion molecule expression in vascular endothelial cells. We further show that modulation of miR-24 alters AAA progression in animal models, and that miR-24 and CHI3L1 represent novel plasma biomarkers of AAA disease progression in humans.

AB - Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of cardiovascular pathology and represent intriguing targets to limit AAA expansion. Here we show, by using two established murine models of AAA disease along with human aortic tissue and plasma analysis, that miR-24 is a key regulator of vascular inflammation and AAA pathology. In vivo and in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the control of miR-24, regulating cytokine synthesis in macrophages as well as their survival, promoting aortic smooth muscle cell migration and cytokine production, and stimulating adhesion molecule expression in vascular endothelial cells. We further show that modulation of miR-24 alters AAA progression in animal models, and that miR-24 and CHI3L1 represent novel plasma biomarkers of AAA disease progression in humans.

KW - Animals

KW - Aorta/metabolism

KW - Aortic Aneurysm, Abdominal/etiology

KW - Biomarkers/blood

KW - Cells, Cultured

KW - Chitinase-3-Like Protein 1

KW - Disease Models, Animal

KW - Disease Progression

KW - Endothelial Cells/metabolism

KW - Glycoproteins/metabolism

KW - Humans

KW - Inflammation/metabolism

KW - Macrophages/metabolism

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - MicroRNAs/metabolism

KW - Myocytes, Smooth Muscle/metabolism

U2 - 10.1038/ncomms6214

DO - 10.1038/ncomms6214

M3 - SCORING: Journal article

C2 - 25358394

VL - 5

SP - 5214

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -