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Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex

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Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex. / Korn, Christoph W; Bach, Dominik R.

In: NAT HUM BEHAV, Vol. 3, No. 7, 07.2019, p. 733-745.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Korn, CW & Bach, DR 2019, 'Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex', NAT HUM BEHAV, vol. 3, no. 7, pp. 733-745. https://doi.org/10.1038/s41562-019-0603-9

APA

Korn, C. W., & Bach, D. R. (2019). Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex. NAT HUM BEHAV, 3(7), 733-745. https://doi.org/10.1038/s41562-019-0603-9

Vancouver

Korn CW, Bach DR. Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex. NAT HUM BEHAV. 2019 Jul;3(7):733-745. https://doi.org/10.1038/s41562-019-0603-9

Bibtex

@article{a0b5452ef7134cd69f3fdd041c7b770d,
title = "Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex",
abstract = "Jointly minimizing multiple threats over extended time horizons enhances survival. Consequently, many tests of approach-avoidance conflicts incorporate multiple threats for probing corollaries of animal and human anxiety. To facilitate computations necessary for threat minimization, the human brain may concurrently harness multiple decision policies and associated neural controllers, but it is unclear which. We combine a task that mimics foraging under predation with behavioural modelling and functional neuroimaging. Human choices rely on immediate predator probability-a myopic heuristic policy-and on the optimal policy, which integrates all relevant variables. Predator probability relates positively and the associated choice uncertainty relates negatively to activations in the anterior hippocampus, amygdala and dorsolateral prefrontal cortex. The optimal policy is positively associated with dorsomedial prefrontal cortex activity. We thus provide a decision-theoretic outlook on the role of the human hippocampus, amygdala and prefrontal cortex in resolving approach-avoidance conflicts relevant for anxiety and integral for survival.",
keywords = "Adult, Amygdala/diagnostic imaging, Anxiety/physiopathology, Appetitive Behavior, Avoidance Learning/physiology, Choice Behavior/physiology, Decision Making/physiology, Female, Functional Neuroimaging, Hippocampus/diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Prefrontal Cortex/diagnostic imaging, Young Adult",
author = "Korn, {Christoph W} and Bach, {Dominik R}",
year = "2019",
month = jul,
doi = "10.1038/s41562-019-0603-9",
language = "English",
volume = "3",
pages = "733--745",
journal = "NAT HUM BEHAV",
issn = "2397-3374",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex

AU - Korn, Christoph W

AU - Bach, Dominik R

PY - 2019/7

Y1 - 2019/7

N2 - Jointly minimizing multiple threats over extended time horizons enhances survival. Consequently, many tests of approach-avoidance conflicts incorporate multiple threats for probing corollaries of animal and human anxiety. To facilitate computations necessary for threat minimization, the human brain may concurrently harness multiple decision policies and associated neural controllers, but it is unclear which. We combine a task that mimics foraging under predation with behavioural modelling and functional neuroimaging. Human choices rely on immediate predator probability-a myopic heuristic policy-and on the optimal policy, which integrates all relevant variables. Predator probability relates positively and the associated choice uncertainty relates negatively to activations in the anterior hippocampus, amygdala and dorsolateral prefrontal cortex. The optimal policy is positively associated with dorsomedial prefrontal cortex activity. We thus provide a decision-theoretic outlook on the role of the human hippocampus, amygdala and prefrontal cortex in resolving approach-avoidance conflicts relevant for anxiety and integral for survival.

AB - Jointly minimizing multiple threats over extended time horizons enhances survival. Consequently, many tests of approach-avoidance conflicts incorporate multiple threats for probing corollaries of animal and human anxiety. To facilitate computations necessary for threat minimization, the human brain may concurrently harness multiple decision policies and associated neural controllers, but it is unclear which. We combine a task that mimics foraging under predation with behavioural modelling and functional neuroimaging. Human choices rely on immediate predator probability-a myopic heuristic policy-and on the optimal policy, which integrates all relevant variables. Predator probability relates positively and the associated choice uncertainty relates negatively to activations in the anterior hippocampus, amygdala and dorsolateral prefrontal cortex. The optimal policy is positively associated with dorsomedial prefrontal cortex activity. We thus provide a decision-theoretic outlook on the role of the human hippocampus, amygdala and prefrontal cortex in resolving approach-avoidance conflicts relevant for anxiety and integral for survival.

KW - Adult

KW - Amygdala/diagnostic imaging

KW - Anxiety/physiopathology

KW - Appetitive Behavior

KW - Avoidance Learning/physiology

KW - Choice Behavior/physiology

KW - Decision Making/physiology

KW - Female

KW - Functional Neuroimaging

KW - Hippocampus/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Prefrontal Cortex/diagnostic imaging

KW - Young Adult

U2 - 10.1038/s41562-019-0603-9

DO - 10.1038/s41562-019-0603-9

M3 - SCORING: Journal article

C2 - 31110338

VL - 3

SP - 733

EP - 745

JO - NAT HUM BEHAV

JF - NAT HUM BEHAV

SN - 2397-3374

IS - 7

ER -