Minimizing Carry-Over Effects After Treatment Failure and Maximizing Therapeutic Outcome. Can Changing the Route of Administration Mitigate the Influence of Treatment History?

TY - JOUR

T1 - Minimizing Carry-Over Effects After Treatment Failure and Maximizing Therapeutic Outcome. Can Changing the Route of Administration Mitigate the Influence of Treatment History?

AU - Hofmann, Mareile

AU - Wrobel, Nathalie

AU - Keßner, Simon

AU - Bingel, Ulrike

PY - 2014/8/1

Y1 - 2014/8/1

N2 - According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect of prior treatment experience on a subsequent treatment depends on the similarity of both treatments. We experimentally induced positive or negative experiences with a topical analgesic treatment in two groups of healthy human subjects. Subsequently, we compared responses to a second, unrelated and systemic analgesic treatment between both the positive and negative group. We found that there was no difference in the analgesic response to the second treatment between the two groups. Our data indicate that a change in administration route might reduce the influence of treatment history and therefore be a way to reduce negative carry-over effects after treatment failure. Future studies will have to validate these findings in a fully balanced design including larger, clinical samples.

AB - According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect of prior treatment experience on a subsequent treatment depends on the similarity of both treatments. We experimentally induced positive or negative experiences with a topical analgesic treatment in two groups of healthy human subjects. Subsequently, we compared responses to a second, unrelated and systemic analgesic treatment between both the positive and negative group. We found that there was no difference in the analgesic response to the second treatment between the two groups. Our data indicate that a change in administration route might reduce the influence of treatment history and therefore be a way to reduce negative carry-over effects after treatment failure. Future studies will have to validate these findings in a fully balanced design including larger, clinical samples.

U2 - 10.1027/2151-2604/a000180

DO - 10.1027/2151-2604/a000180

M3 - SCORING: Journal article

VL - 222

SP - 171

EP - 178

JO - Z PSYCHOL

JF - Z PSYCHOL

SN - 2190-8370

IS - 3

ER -