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Mineralocorticoid receptor function in patients with posttraumatic stress disorder.

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Mineralocorticoid receptor function in patients with posttraumatic stress disorder. / Kellner, Michael; Baker, Dewleen G; Yassouridis, Alexander; Bettinger, Silke; Otte, Christian; Naber, Dieter; Wiedemann, Klaus.

In: AM J PSYCHIAT, Vol. 159, No. 11, 11, 2002, p. 1938-1940.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kellner, M, Baker, DG, Yassouridis, A, Bettinger, S, Otte, C, Naber, D & Wiedemann, K 2002, 'Mineralocorticoid receptor function in patients with posttraumatic stress disorder.', AM J PSYCHIAT, vol. 159, no. 11, 11, pp. 1938-1940. <http://www.ncbi.nlm.nih.gov/pubmed/12411234?dopt=Citation>

APA

Kellner, M., Baker, D. G., Yassouridis, A., Bettinger, S., Otte, C., Naber, D., & Wiedemann, K. (2002). Mineralocorticoid receptor function in patients with posttraumatic stress disorder. AM J PSYCHIAT, 159(11), 1938-1940. [11]. http://www.ncbi.nlm.nih.gov/pubmed/12411234?dopt=Citation

Vancouver

Kellner M, Baker DG, Yassouridis A, Bettinger S, Otte C, Naber D et al. Mineralocorticoid receptor function in patients with posttraumatic stress disorder. AM J PSYCHIAT. 2002;159(11):1938-1940. 11.

Bibtex

@article{cf67d5b5a7a74f8f9f0d2a8d90f876f9,
title = "Mineralocorticoid receptor function in patients with posttraumatic stress disorder.",
abstract = "OBJECTIVE: The study examined whether enhanced limbic mineralocorticoid receptor activity resulting in negative glucocorticoid feedback could contribute to the diminished basal and stress-induced cortisol output reported in patients with posttraumatic stress disorder (PTSD). METHOD: The effects of acute antimineralocorticoid (spironolactone) versus placebo pretreatment on levels of plasma cortisol at baseline and after stimulations with corticotropin-releasing hormone (CRH) and on adrenocorticotropic hormone (ACTH) level were measured in 12 PTSD patients and 12 healthy comparison subjects. RESULTS: Spironolactone significantly elevated basal cortisol and ACTH concentrations as well as cortisol secretion after CRH stimulation, but no differential effect between PTSD patients and comparison subjects was detected. CONCLUSIONS: The results indicate intact, but not enhanced, mineralocorticoid receptor function in PTSD. The study's experimental conditions did not allow determination of whether other compensatory factors might have masked the putative mineralocorticoid receptor changes.",
author = "Michael Kellner and Baker, {Dewleen G} and Alexander Yassouridis and Silke Bettinger and Christian Otte and Dieter Naber and Klaus Wiedemann",
year = "2002",
language = "Deutsch",
volume = "159",
pages = "1938--1940",
journal = "AM J PSYCHIAT",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "11",

}

RIS

TY - JOUR

T1 - Mineralocorticoid receptor function in patients with posttraumatic stress disorder.

AU - Kellner, Michael

AU - Baker, Dewleen G

AU - Yassouridis, Alexander

AU - Bettinger, Silke

AU - Otte, Christian

AU - Naber, Dieter

AU - Wiedemann, Klaus

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: The study examined whether enhanced limbic mineralocorticoid receptor activity resulting in negative glucocorticoid feedback could contribute to the diminished basal and stress-induced cortisol output reported in patients with posttraumatic stress disorder (PTSD). METHOD: The effects of acute antimineralocorticoid (spironolactone) versus placebo pretreatment on levels of plasma cortisol at baseline and after stimulations with corticotropin-releasing hormone (CRH) and on adrenocorticotropic hormone (ACTH) level were measured in 12 PTSD patients and 12 healthy comparison subjects. RESULTS: Spironolactone significantly elevated basal cortisol and ACTH concentrations as well as cortisol secretion after CRH stimulation, but no differential effect between PTSD patients and comparison subjects was detected. CONCLUSIONS: The results indicate intact, but not enhanced, mineralocorticoid receptor function in PTSD. The study's experimental conditions did not allow determination of whether other compensatory factors might have masked the putative mineralocorticoid receptor changes.

AB - OBJECTIVE: The study examined whether enhanced limbic mineralocorticoid receptor activity resulting in negative glucocorticoid feedback could contribute to the diminished basal and stress-induced cortisol output reported in patients with posttraumatic stress disorder (PTSD). METHOD: The effects of acute antimineralocorticoid (spironolactone) versus placebo pretreatment on levels of plasma cortisol at baseline and after stimulations with corticotropin-releasing hormone (CRH) and on adrenocorticotropic hormone (ACTH) level were measured in 12 PTSD patients and 12 healthy comparison subjects. RESULTS: Spironolactone significantly elevated basal cortisol and ACTH concentrations as well as cortisol secretion after CRH stimulation, but no differential effect between PTSD patients and comparison subjects was detected. CONCLUSIONS: The results indicate intact, but not enhanced, mineralocorticoid receptor function in PTSD. The study's experimental conditions did not allow determination of whether other compensatory factors might have masked the putative mineralocorticoid receptor changes.

M3 - SCORING: Zeitschriftenaufsatz

VL - 159

SP - 1938

EP - 1940

JO - AM J PSYCHIAT

JF - AM J PSYCHIAT

SN - 0002-953X

IS - 11

M1 - 11

ER -