Midterm results after uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for symptomatic uterine fibroids

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Midterm results after uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for symptomatic uterine fibroids. / Froeling, V; Meckelburg, K; Scheurig-Muenkler, C; Schreiter, N F; Kamp, J; Maurer, M H; Beck, A; Hamm, B; Kroencke, T J.

In: CARDIOVASC INTER RAD, Vol. 36, No. 6, 12.2013, p. 1508-1513.

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@article{f6546bbc323445848a4d6ffff88f763b,
title = "Midterm results after uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for symptomatic uterine fibroids",
abstract = "PURPOSE: To compare the rate of reintervention and midterm changes in symptom severity (SS) and Total health-related quality of life (HRQoL) scores after uterine artery embolization (UAE) and magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic uterine fibroids.METHODS: Eighty women (median age 38.3 years), equally eligible for MR-g HIFU and UAE who underwent one of both treatments between 2002 and 2009 at our institution, were included. The primary end point of the study was defined as the rate of reintervention after both therapies. The secondary outcome was defined as changes in SS and Total HRQoL scores after treatment. SS and Total HRQoL scores before treatment and at midterm follow-up (median 13.3 months) were assessed by the uterine fibroid symptom and quality-of-life questionnaire (UFS-QoL) and compared.RESULTS: The rate of reintervention was significantly lower after UAE than after MR-g HIFU (p = 0.002). After both treatments, SS and Total HRQoL scores improved significantly from baseline to follow-up (UAE: p < 0.001, p < 0.001; MR-g HIFU: p = 0.002, p < 0.001). Total HRQoL scores were significantly higher after UAE than after MR-g HIFU (p = 0.032). Changes in the SS scores did not differ significantly for both treatments (p = 0.061).CONCLUSION: UAE and MR-g HIFU significantly improved the health-related quality of life of women with symptomatic uterine fibroids. After UAE, the change in Total HRQoL score improvement was significantly better, and a significantly lower rate of reintervention was observed.",
keywords = "Adult, Combined Modality Therapy/methods, Female, High-Intensity Focused Ultrasound Ablation/methods, Humans, Leiomyoma/surgery, Magnetic Resonance Imaging/methods, Quality of Life, Retreatment/statistics & numerical data, Severity of Illness Index, Surveys and Questionnaires, Treatment Outcome, Ultrasonography, Interventional/methods, Uterine Artery Embolization/methods, Uterine Neoplasms/surgery",
author = "V Froeling and K Meckelburg and C Scheurig-Muenkler and Schreiter, {N F} and J Kamp and Maurer, {M H} and A Beck and B Hamm and Kroencke, {T J}",
year = "2013",
month = dec,
doi = "10.1007/s00270-013-0582-6",
language = "English",
volume = "36",
pages = "1508--1513",
journal = "CARDIOVASC INTER RAD",
issn = "0174-1551",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Midterm results after uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for symptomatic uterine fibroids

AU - Froeling, V

AU - Meckelburg, K

AU - Scheurig-Muenkler, C

AU - Schreiter, N F

AU - Kamp, J

AU - Maurer, M H

AU - Beck, A

AU - Hamm, B

AU - Kroencke, T J

PY - 2013/12

Y1 - 2013/12

N2 - PURPOSE: To compare the rate of reintervention and midterm changes in symptom severity (SS) and Total health-related quality of life (HRQoL) scores after uterine artery embolization (UAE) and magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic uterine fibroids.METHODS: Eighty women (median age 38.3 years), equally eligible for MR-g HIFU and UAE who underwent one of both treatments between 2002 and 2009 at our institution, were included. The primary end point of the study was defined as the rate of reintervention after both therapies. The secondary outcome was defined as changes in SS and Total HRQoL scores after treatment. SS and Total HRQoL scores before treatment and at midterm follow-up (median 13.3 months) were assessed by the uterine fibroid symptom and quality-of-life questionnaire (UFS-QoL) and compared.RESULTS: The rate of reintervention was significantly lower after UAE than after MR-g HIFU (p = 0.002). After both treatments, SS and Total HRQoL scores improved significantly from baseline to follow-up (UAE: p < 0.001, p < 0.001; MR-g HIFU: p = 0.002, p < 0.001). Total HRQoL scores were significantly higher after UAE than after MR-g HIFU (p = 0.032). Changes in the SS scores did not differ significantly for both treatments (p = 0.061).CONCLUSION: UAE and MR-g HIFU significantly improved the health-related quality of life of women with symptomatic uterine fibroids. After UAE, the change in Total HRQoL score improvement was significantly better, and a significantly lower rate of reintervention was observed.

AB - PURPOSE: To compare the rate of reintervention and midterm changes in symptom severity (SS) and Total health-related quality of life (HRQoL) scores after uterine artery embolization (UAE) and magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic uterine fibroids.METHODS: Eighty women (median age 38.3 years), equally eligible for MR-g HIFU and UAE who underwent one of both treatments between 2002 and 2009 at our institution, were included. The primary end point of the study was defined as the rate of reintervention after both therapies. The secondary outcome was defined as changes in SS and Total HRQoL scores after treatment. SS and Total HRQoL scores before treatment and at midterm follow-up (median 13.3 months) were assessed by the uterine fibroid symptom and quality-of-life questionnaire (UFS-QoL) and compared.RESULTS: The rate of reintervention was significantly lower after UAE than after MR-g HIFU (p = 0.002). After both treatments, SS and Total HRQoL scores improved significantly from baseline to follow-up (UAE: p < 0.001, p < 0.001; MR-g HIFU: p = 0.002, p < 0.001). Total HRQoL scores were significantly higher after UAE than after MR-g HIFU (p = 0.032). Changes in the SS scores did not differ significantly for both treatments (p = 0.061).CONCLUSION: UAE and MR-g HIFU significantly improved the health-related quality of life of women with symptomatic uterine fibroids. After UAE, the change in Total HRQoL score improvement was significantly better, and a significantly lower rate of reintervention was observed.

KW - Adult

KW - Combined Modality Therapy/methods

KW - Female

KW - High-Intensity Focused Ultrasound Ablation/methods

KW - Humans

KW - Leiomyoma/surgery

KW - Magnetic Resonance Imaging/methods

KW - Quality of Life

KW - Retreatment/statistics & numerical data

KW - Severity of Illness Index

KW - Surveys and Questionnaires

KW - Treatment Outcome

KW - Ultrasonography, Interventional/methods

KW - Uterine Artery Embolization/methods

KW - Uterine Neoplasms/surgery

U2 - 10.1007/s00270-013-0582-6

DO - 10.1007/s00270-013-0582-6

M3 - SCORING: Journal article

C2 - 23456309

VL - 36

SP - 1508

EP - 1513

JO - CARDIOVASC INTER RAD

JF - CARDIOVASC INTER RAD

SN - 0174-1551

IS - 6

ER -