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Midkine as a prognostic marker for gastrointestinal stromal tumors.

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Midkine as a prognostic marker for gastrointestinal stromal tumors. / Kaifi, Jussuf; Fiegel, Henning; Rafnsdottir, Svanheidur L; Aridome, Kuniaki; Schurr, Paulus; Reichelt, Uta; Wachowiak, Robin; Kleinhans, Helge; Yekebas, Emre F.; Mann, Oliver; Ichihara-Tanaka, Keiko; Muramatsu, Takashi; Kluth, Dietrich; Strate, Tim; Izbicki, Jakob R.

In: J CANCER RES CLIN, Vol. 133, No. 7, 7, 2007, p. 431-435.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaifi, J, Fiegel, H, Rafnsdottir, SL, Aridome, K, Schurr, P, Reichelt, U, Wachowiak, R, Kleinhans, H, Yekebas, EF, Mann, O, Ichihara-Tanaka, K, Muramatsu, T, Kluth, D, Strate, T & Izbicki, JR 2007, 'Midkine as a prognostic marker for gastrointestinal stromal tumors.', J CANCER RES CLIN, vol. 133, no. 7, 7, pp. 431-435. <http://www.ncbi.nlm.nih.gov/pubmed/17221186?dopt=Citation>

APA

Kaifi, J., Fiegel, H., Rafnsdottir, S. L., Aridome, K., Schurr, P., Reichelt, U., Wachowiak, R., Kleinhans, H., Yekebas, E. F., Mann, O., Ichihara-Tanaka, K., Muramatsu, T., Kluth, D., Strate, T., & Izbicki, J. R. (2007). Midkine as a prognostic marker for gastrointestinal stromal tumors. J CANCER RES CLIN, 133(7), 431-435. [7]. http://www.ncbi.nlm.nih.gov/pubmed/17221186?dopt=Citation

Vancouver

Kaifi J, Fiegel H, Rafnsdottir SL, Aridome K, Schurr P, Reichelt U et al. Midkine as a prognostic marker for gastrointestinal stromal tumors. J CANCER RES CLIN. 2007;133(7):431-435. 7.

Bibtex

@article{1728c83d6b2d41928a2822a51e19f817,
title = "Midkine as a prognostic marker for gastrointestinal stromal tumors.",
abstract = "PURPOSE: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The outcome of patients with gastrointestinal stromal tumors (GISTs) is correlated with tumor size and mitotic count. The aim of this study was to determine MK expression in GISTs. METHODS: Midkine was detected in 31 (55%) of 57 surgically resected GISTs by immunohistochemistry with a rabbit antibody against MK and peroxidase method. RESULTS: A significant worse outcome of MK-positive patients was found (P <0.05; log rank test). Multivariate Cox regression analysis showed an independent prognostic impact (relative risk for overall survival 3.64; P <0.05). Interestingly, MK expression was significantly associated with mitotic rate (P <0.05; Chi-squared test), but not with tumor size (P = 0.97). CONCLUSIONS: Taken together, MK is a prognostic marker for GIST patients. MK might also be a useful peripheral tumor marker since it can be detected in peripheral serum. Future studies should involve higher GIST patient numbers including tumor and serum samples for detection of MK.",
author = "Jussuf Kaifi and Henning Fiegel and Rafnsdottir, {Svanheidur L} and Kuniaki Aridome and Paulus Schurr and Uta Reichelt and Robin Wachowiak and Helge Kleinhans and Yekebas, {Emre F.} and Oliver Mann and Keiko Ichihara-Tanaka and Takashi Muramatsu and Dietrich Kluth and Tim Strate and Izbicki, {Jakob R.}",
year = "2007",
language = "Deutsch",
volume = "133",
pages = "431--435",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Midkine as a prognostic marker for gastrointestinal stromal tumors.

AU - Kaifi, Jussuf

AU - Fiegel, Henning

AU - Rafnsdottir, Svanheidur L

AU - Aridome, Kuniaki

AU - Schurr, Paulus

AU - Reichelt, Uta

AU - Wachowiak, Robin

AU - Kleinhans, Helge

AU - Yekebas, Emre F.

AU - Mann, Oliver

AU - Ichihara-Tanaka, Keiko

AU - Muramatsu, Takashi

AU - Kluth, Dietrich

AU - Strate, Tim

AU - Izbicki, Jakob R.

PY - 2007

Y1 - 2007

N2 - PURPOSE: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The outcome of patients with gastrointestinal stromal tumors (GISTs) is correlated with tumor size and mitotic count. The aim of this study was to determine MK expression in GISTs. METHODS: Midkine was detected in 31 (55%) of 57 surgically resected GISTs by immunohistochemistry with a rabbit antibody against MK and peroxidase method. RESULTS: A significant worse outcome of MK-positive patients was found (P <0.05; log rank test). Multivariate Cox regression analysis showed an independent prognostic impact (relative risk for overall survival 3.64; P <0.05). Interestingly, MK expression was significantly associated with mitotic rate (P <0.05; Chi-squared test), but not with tumor size (P = 0.97). CONCLUSIONS: Taken together, MK is a prognostic marker for GIST patients. MK might also be a useful peripheral tumor marker since it can be detected in peripheral serum. Future studies should involve higher GIST patient numbers including tumor and serum samples for detection of MK.

AB - PURPOSE: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The outcome of patients with gastrointestinal stromal tumors (GISTs) is correlated with tumor size and mitotic count. The aim of this study was to determine MK expression in GISTs. METHODS: Midkine was detected in 31 (55%) of 57 surgically resected GISTs by immunohistochemistry with a rabbit antibody against MK and peroxidase method. RESULTS: A significant worse outcome of MK-positive patients was found (P <0.05; log rank test). Multivariate Cox regression analysis showed an independent prognostic impact (relative risk for overall survival 3.64; P <0.05). Interestingly, MK expression was significantly associated with mitotic rate (P <0.05; Chi-squared test), but not with tumor size (P = 0.97). CONCLUSIONS: Taken together, MK is a prognostic marker for GIST patients. MK might also be a useful peripheral tumor marker since it can be detected in peripheral serum. Future studies should involve higher GIST patient numbers including tumor and serum samples for detection of MK.

M3 - SCORING: Zeitschriftenaufsatz

VL - 133

SP - 431

EP - 435

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 7

M1 - 7

ER -