MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells

Arun K Rooj; Franz Ricklefs; Marco Mineo; Ichiro Nakano; E Antonio Chiocca; Agnieszka Bronisz; Jakub Godlewski

doi:10.1016/j.celrep.2017.05.040

MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells

Standard

MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. / Rooj, Arun K; Ricklefs, Franz; Mineo, Marco; Nakano, Ichiro; Chiocca, E Antonio; Bronisz, Agnieszka; Godlewski, Jakub.

In: CELL REP, Vol. 19, No. 10, 06.06.2017, p. 2026-2032.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rooj, AK, Ricklefs, F, Mineo, M, Nakano, I, Chiocca, EA, Bronisz, A & Godlewski, J 2017, 'MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells', CELL REP, vol. 19, no. 10, pp. 2026-2032. https://doi.org/10.1016/j.celrep.2017.05.040

APA

Rooj, A. K., Ricklefs, F., Mineo, M., Nakano, I., Chiocca, E. A., Bronisz, A., & Godlewski, J. (2017). MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. CELL REP, 19(10), 2026-2032. https://doi.org/10.1016/j.celrep.2017.05.040

Vancouver

Rooj AK, Ricklefs F, Mineo M, Nakano I, Chiocca EA, Bronisz A et al. MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. CELL REP. 2017 Jun 6;19(10):2026-2032. https://doi.org/10.1016/j.celrep.2017.05.040

Bibtex

@article{bf4c865a4210423b8d5441ba86735ce3,

title = "MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells",

abstract = "Large-scale transcriptomic profiling of glioblastoma (GBM) into subtypes has provided remarkable insight into the pathobiology and heterogeneous nature of this disease. The mechanisms of speciation and inter-subtype transitions of these molecular subtypes require better characterization to facilitate the development of subtype-specific targeting strategies. The deregulation of microRNA expression among GBM subtypes and their subtype-specific targeting mechanisms are poorly understood. To reveal the underlying basis of microRNA-driven complex subpopulation dynamics within the heterogeneous intra-tumoral ecosystem, we characterized the expression of the subtype-enriched microRNA-128 (miR-128) in transcriptionally and phenotypically diverse subpopulations of patient-derived glioblastoma stem-like cells. Because microRNAs are capable of re-arranging the molecular landscape in a cell-type-specific manner, we argue that alterations in miR-128 levels are a potent mechanism of bidirectional transitions between GBM subpopulations, resulting in intermediate hybrid stages and emphasizing highly intricate intra-tumoral networking.",

keywords = "Journal Article",

author = "Rooj, {Arun K} and Franz Ricklefs and Marco Mineo and Ichiro Nakano and Chiocca, {E Antonio} and Agnieszka Bronisz and Jakub Godlewski",

year = "2017",

month = jun,

day = "6",

doi = "10.1016/j.celrep.2017.05.040",

language = "English",

volume = "19",

pages = "2026--2032",

journal = "CELL REP",

issn = "2211-1247",

publisher = "Elsevier",

number = "10",

}

RIS

TY - JOUR

T1 - MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells

AU - Rooj, Arun K

AU - Ricklefs, Franz

AU - Mineo, Marco

AU - Nakano, Ichiro

AU - Chiocca, E Antonio

AU - Bronisz, Agnieszka

AU - Godlewski, Jakub

PY - 2017/6/6

Y1 - 2017/6/6

N2 - Large-scale transcriptomic profiling of glioblastoma (GBM) into subtypes has provided remarkable insight into the pathobiology and heterogeneous nature of this disease. The mechanisms of speciation and inter-subtype transitions of these molecular subtypes require better characterization to facilitate the development of subtype-specific targeting strategies. The deregulation of microRNA expression among GBM subtypes and their subtype-specific targeting mechanisms are poorly understood. To reveal the underlying basis of microRNA-driven complex subpopulation dynamics within the heterogeneous intra-tumoral ecosystem, we characterized the expression of the subtype-enriched microRNA-128 (miR-128) in transcriptionally and phenotypically diverse subpopulations of patient-derived glioblastoma stem-like cells. Because microRNAs are capable of re-arranging the molecular landscape in a cell-type-specific manner, we argue that alterations in miR-128 levels are a potent mechanism of bidirectional transitions between GBM subpopulations, resulting in intermediate hybrid stages and emphasizing highly intricate intra-tumoral networking.

AB - Large-scale transcriptomic profiling of glioblastoma (GBM) into subtypes has provided remarkable insight into the pathobiology and heterogeneous nature of this disease. The mechanisms of speciation and inter-subtype transitions of these molecular subtypes require better characterization to facilitate the development of subtype-specific targeting strategies. The deregulation of microRNA expression among GBM subtypes and their subtype-specific targeting mechanisms are poorly understood. To reveal the underlying basis of microRNA-driven complex subpopulation dynamics within the heterogeneous intra-tumoral ecosystem, we characterized the expression of the subtype-enriched microRNA-128 (miR-128) in transcriptionally and phenotypically diverse subpopulations of patient-derived glioblastoma stem-like cells. Because microRNAs are capable of re-arranging the molecular landscape in a cell-type-specific manner, we argue that alterations in miR-128 levels are a potent mechanism of bidirectional transitions between GBM subpopulations, resulting in intermediate hybrid stages and emphasizing highly intricate intra-tumoral networking.

KW - Journal Article

U2 - 10.1016/j.celrep.2017.05.040

DO - 10.1016/j.celrep.2017.05.040

M3 - SCORING: Journal article

C2 - 28591575

VL - 19

SP - 2026

EP - 2032

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 10

ER -