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Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling

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Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling. / Barry-Carroll, Liam; Greulich, Philip; Marshall, Abigail R; Riecken, Kristoffer; Fehse, Boris; Askew, Katharine E; Li, Kaizhen; Garaschuk, Olga; Menassa, David A; Gomez-Nicola, Diego.

In: CELL REP, Vol. 42, No. 5, 30.05.2023, p. 112425.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Barry-Carroll, L, Greulich, P, Marshall, AR, Riecken, K, Fehse, B, Askew, KE, Li, K, Garaschuk, O, Menassa, DA & Gomez-Nicola, D 2023, 'Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling', CELL REP, vol. 42, no. 5, pp. 112425. https://doi.org/10.1016/j.celrep.2023.112425

APA

Barry-Carroll, L., Greulich, P., Marshall, A. R., Riecken, K., Fehse, B., Askew, K. E., Li, K., Garaschuk, O., Menassa, D. A., & Gomez-Nicola, D. (2023). Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling. CELL REP, 42(5), 112425. https://doi.org/10.1016/j.celrep.2023.112425

Vancouver

Barry-Carroll L, Greulich P, Marshall AR, Riecken K, Fehse B, Askew KE et al. Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling. CELL REP. 2023 May 30;42(5):112425. https://doi.org/10.1016/j.celrep.2023.112425

Bibtex

@article{b6945c3b030e449cb606e04bc69e5a88,
title = "Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling",
abstract = "Microglia arise from the yolk sac and enter the brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation and eventually colonize the entire brain by the third postnatal week in mice. However, the intricacies of their developmental expansion remain unclear. Here, we characterize the proliferative dynamics of microglia during embryonic and postnatal development using complementary fate-mapping techniques. We demonstrate that the developmental colonization of the brain is facilitated by clonal expansion of highly proliferative microglial progenitors that occupy spatial niches throughout the brain. Moreover, the spatial distribution of microglia switches from a clustered to a random pattern between embryonic and late postnatal development. Interestingly, the developmental increase in microglial numbers follows the proportional growth of the brain in an allometric manner until a mosaic distribution has been established. Overall, our findings offer insight into how the competition for space may drive microglial colonization by clonal expansion during development.",
author = "Liam Barry-Carroll and Philip Greulich and Marshall, {Abigail R} and Kristoffer Riecken and Boris Fehse and Askew, {Katharine E} and Kaizhen Li and Olga Garaschuk and Menassa, {David A} and Diego Gomez-Nicola",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = may,
day = "30",
doi = "10.1016/j.celrep.2023.112425",
language = "English",
volume = "42",
pages = "112425",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling

AU - Barry-Carroll, Liam

AU - Greulich, Philip

AU - Marshall, Abigail R

AU - Riecken, Kristoffer

AU - Fehse, Boris

AU - Askew, Katharine E

AU - Li, Kaizhen

AU - Garaschuk, Olga

AU - Menassa, David A

AU - Gomez-Nicola, Diego

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023/5/30

Y1 - 2023/5/30

N2 - Microglia arise from the yolk sac and enter the brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation and eventually colonize the entire brain by the third postnatal week in mice. However, the intricacies of their developmental expansion remain unclear. Here, we characterize the proliferative dynamics of microglia during embryonic and postnatal development using complementary fate-mapping techniques. We demonstrate that the developmental colonization of the brain is facilitated by clonal expansion of highly proliferative microglial progenitors that occupy spatial niches throughout the brain. Moreover, the spatial distribution of microglia switches from a clustered to a random pattern between embryonic and late postnatal development. Interestingly, the developmental increase in microglial numbers follows the proportional growth of the brain in an allometric manner until a mosaic distribution has been established. Overall, our findings offer insight into how the competition for space may drive microglial colonization by clonal expansion during development.

AB - Microglia arise from the yolk sac and enter the brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation and eventually colonize the entire brain by the third postnatal week in mice. However, the intricacies of their developmental expansion remain unclear. Here, we characterize the proliferative dynamics of microglia during embryonic and postnatal development using complementary fate-mapping techniques. We demonstrate that the developmental colonization of the brain is facilitated by clonal expansion of highly proliferative microglial progenitors that occupy spatial niches throughout the brain. Moreover, the spatial distribution of microglia switches from a clustered to a random pattern between embryonic and late postnatal development. Interestingly, the developmental increase in microglial numbers follows the proportional growth of the brain in an allometric manner until a mosaic distribution has been established. Overall, our findings offer insight into how the competition for space may drive microglial colonization by clonal expansion during development.

U2 - 10.1016/j.celrep.2023.112425

DO - 10.1016/j.celrep.2023.112425

M3 - SCORING: Journal article

C2 - 37099424

VL - 42

SP - 112425

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -