Microdont Developing Outside the Alveolar Process and Within Oral Diffuse and Plexiform Neurofibroma in Neurofibromatosis Type 1
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Microdont Developing Outside the Alveolar Process and Within Oral Diffuse and Plexiform Neurofibroma in Neurofibromatosis Type 1. / Friedrich, Reinhard E; Scheuer, Hannah T; Zustin, Jozef; Luebke, Andreas M; Hagel, Christian; Scheuer, Hanna A.
In: ANTICANCER RES, Vol. 41, No. 4, 04.2021, p. 2083-2092.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Microdont Developing Outside the Alveolar Process and Within Oral Diffuse and Plexiform Neurofibroma in Neurofibromatosis Type 1
AU - Friedrich, Reinhard E
AU - Scheuer, Hannah T
AU - Zustin, Jozef
AU - Luebke, Andreas M
AU - Hagel, Christian
AU - Scheuer, Hanna A
N1 - Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - BACKGROUND/AIM: Numerical aberrations of permanent dentition and dystopic tooth eruption are part of the phenotype of the tumor predisposition syndrome neurofibromatosis type 1 (NF1). In these cases, surplus tooth germs usually develop in the alveolar processes of the jaw. This report attests to the dystopic development of a dysplastic supernumerary tooth in NF1 arising outside the jaw.CASE REPORT: The 8-year-old male patient developed a microdont outside the bone and above the occlusal plane of the retained maxillary right second molar. The supernumerary tooth was completely embedded in oral soft tissue. Hyperplastic oral soft tissue in the molar region and microdont were excised. Specimen of the mucosa surrounding the teeth was interspersed with diffuse and plexiform neurofibroma. The retained upper right first molar emerged spontaneously within a few months after surgery. The upper right second molar did not change position.CONCLUSION: Odontogenesis can take place within tumorous oral mucosa in NF1. Surgical removal of the tumorous mucous membrane facilitates tooth eruption in some cases.
AB - BACKGROUND/AIM: Numerical aberrations of permanent dentition and dystopic tooth eruption are part of the phenotype of the tumor predisposition syndrome neurofibromatosis type 1 (NF1). In these cases, surplus tooth germs usually develop in the alveolar processes of the jaw. This report attests to the dystopic development of a dysplastic supernumerary tooth in NF1 arising outside the jaw.CASE REPORT: The 8-year-old male patient developed a microdont outside the bone and above the occlusal plane of the retained maxillary right second molar. The supernumerary tooth was completely embedded in oral soft tissue. Hyperplastic oral soft tissue in the molar region and microdont were excised. Specimen of the mucosa surrounding the teeth was interspersed with diffuse and plexiform neurofibroma. The retained upper right first molar emerged spontaneously within a few months after surgery. The upper right second molar did not change position.CONCLUSION: Odontogenesis can take place within tumorous oral mucosa in NF1. Surgical removal of the tumorous mucous membrane facilitates tooth eruption in some cases.
KW - Alveolar Process/abnormalities
KW - Child
KW - Humans
KW - Male
KW - Mouth Neoplasms/complications
KW - Neurofibroma, Plexiform/complications
KW - Neurofibromatosis 1/complications
KW - Tooth Abnormalities/diagnosis
KW - Tooth Eruption, Ectopic/diagnosis
KW - Tooth, Deciduous/abnormalities
KW - Tooth, Supernumerary/diagnosis
U2 - 10.21873/anticanres.14979
DO - 10.21873/anticanres.14979
M3 - SCORING: Journal article
C2 - 33813418
VL - 41
SP - 2083
EP - 2092
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 4
ER -
