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Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

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Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. / Schaupp, Laura; Muth, Sabine; Rogell, Leif; Kofoed-Branzk, Michael; Melchior, Felix; Lienenklaus, Stefan; Ganal-Vonarburg, Stephanie C; Klein, Matthias; Guendel, Fabian; Hain, Tobias; Schütze, Kristian; Grundmann, Ulrike; Schmitt, Vanessa; Dorsch, Martina; Spanier, Julia; Larsen, Pia-Katharina; Schwanz, Thomas; Jäckel, Sven; Reinhardt, Christoph; Bopp, Tobias; Danckwardt, Sven; Mahnke, Karsten; Heinz, Gitta Anne; Mashreghi, Mir-Farzin; Durek, Pawel; Kalinke, Ulrich; Kretz, Oliver; Huber, Tobias B; Weiss, Siegfried; Wilhelm, Christoph; Macpherson, Andrew J; Schild, Hansjörg; Diefenbach, Andreas; Probst, Hans Christian.

In: CELL, Vol. 181, No. 5, 28.05.2020, p. 1080-1096.e19.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schaupp, L, Muth, S, Rogell, L, Kofoed-Branzk, M, Melchior, F, Lienenklaus, S, Ganal-Vonarburg, SC, Klein, M, Guendel, F, Hain, T, Schütze, K, Grundmann, U, Schmitt, V, Dorsch, M, Spanier, J, Larsen, P-K, Schwanz, T, Jäckel, S, Reinhardt, C, Bopp, T, Danckwardt, S, Mahnke, K, Heinz, GA, Mashreghi, M-F, Durek, P, Kalinke, U, Kretz, O, Huber, TB, Weiss, S, Wilhelm, C, Macpherson, AJ, Schild, H, Diefenbach, A & Probst, HC 2020, 'Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells', CELL, vol. 181, no. 5, pp. 1080-1096.e19. https://doi.org/10.1016/j.cell.2020.04.022

APA

Schaupp, L., Muth, S., Rogell, L., Kofoed-Branzk, M., Melchior, F., Lienenklaus, S., Ganal-Vonarburg, S. C., Klein, M., Guendel, F., Hain, T., Schütze, K., Grundmann, U., Schmitt, V., Dorsch, M., Spanier, J., Larsen, P-K., Schwanz, T., Jäckel, S., Reinhardt, C., ... Probst, H. C. (2020). Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. CELL, 181(5), 1080-1096.e19. https://doi.org/10.1016/j.cell.2020.04.022

Vancouver

Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S et al. Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. CELL. 2020 May 28;181(5):1080-1096.e19. https://doi.org/10.1016/j.cell.2020.04.022

Bibtex

@article{097d1ff049744b06b750975d0b463732,
title = "Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells",
abstract = "Environmental signals shape host physiology and fitness. Microbiota-derived cues are required to program conventional dendritic cells (cDCs) during the steady state so that they can promptly respond and initiate adaptive immune responses when encountering pathogens. However, the molecular underpinnings of microbiota-guided instructive programs are not well understood. Here, we report that the indigenous microbiota controls constitutive production of type I interferons (IFN-I) by plasmacytoid DCs. Using genome-wide analysis of transcriptional and epigenetic regulomes of cDCs from germ-free and IFN-I receptor (IFNAR)-deficient mice, we found that tonic IFNAR signaling instructs a specific epigenomic and metabolic basal state that poises cDCs for future pathogen combat. However, such beneficial biological function comes with a trade-off. Instructed cDCs can prime T cell responses against harmless peripheral antigens when removing roadblocks of peripheral tolerance. Our data provide fresh insights into the evolutionary trade-offs that come with successful adaptation of vertebrates to their microbial environment.",
author = "Laura Schaupp and Sabine Muth and Leif Rogell and Michael Kofoed-Branzk and Felix Melchior and Stefan Lienenklaus and Ganal-Vonarburg, {Stephanie C} and Matthias Klein and Fabian Guendel and Tobias Hain and Kristian Sch{\"u}tze and Ulrike Grundmann and Vanessa Schmitt and Martina Dorsch and Julia Spanier and Pia-Katharina Larsen and Thomas Schwanz and Sven J{\"a}ckel and Christoph Reinhardt and Tobias Bopp and Sven Danckwardt and Karsten Mahnke and Heinz, {Gitta Anne} and Mir-Farzin Mashreghi and Pawel Durek and Ulrich Kalinke and Oliver Kretz and Huber, {Tobias B} and Siegfried Weiss and Christoph Wilhelm and Macpherson, {Andrew J} and Hansj{\"o}rg Schild and Andreas Diefenbach and Probst, {Hans Christian}",
note = "Copyright {\textcopyright} 2020 Elsevier Inc. All rights reserved.",
year = "2020",
month = may,
day = "28",
doi = "10.1016/j.cell.2020.04.022",
language = "English",
volume = "181",
pages = "1080--1096.e19",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

AU - Schaupp, Laura

AU - Muth, Sabine

AU - Rogell, Leif

AU - Kofoed-Branzk, Michael

AU - Melchior, Felix

AU - Lienenklaus, Stefan

AU - Ganal-Vonarburg, Stephanie C

AU - Klein, Matthias

AU - Guendel, Fabian

AU - Hain, Tobias

AU - Schütze, Kristian

AU - Grundmann, Ulrike

AU - Schmitt, Vanessa

AU - Dorsch, Martina

AU - Spanier, Julia

AU - Larsen, Pia-Katharina

AU - Schwanz, Thomas

AU - Jäckel, Sven

AU - Reinhardt, Christoph

AU - Bopp, Tobias

AU - Danckwardt, Sven

AU - Mahnke, Karsten

AU - Heinz, Gitta Anne

AU - Mashreghi, Mir-Farzin

AU - Durek, Pawel

AU - Kalinke, Ulrich

AU - Kretz, Oliver

AU - Huber, Tobias B

AU - Weiss, Siegfried

AU - Wilhelm, Christoph

AU - Macpherson, Andrew J

AU - Schild, Hansjörg

AU - Diefenbach, Andreas

AU - Probst, Hans Christian

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2020/5/28

Y1 - 2020/5/28

N2 - Environmental signals shape host physiology and fitness. Microbiota-derived cues are required to program conventional dendritic cells (cDCs) during the steady state so that they can promptly respond and initiate adaptive immune responses when encountering pathogens. However, the molecular underpinnings of microbiota-guided instructive programs are not well understood. Here, we report that the indigenous microbiota controls constitutive production of type I interferons (IFN-I) by plasmacytoid DCs. Using genome-wide analysis of transcriptional and epigenetic regulomes of cDCs from germ-free and IFN-I receptor (IFNAR)-deficient mice, we found that tonic IFNAR signaling instructs a specific epigenomic and metabolic basal state that poises cDCs for future pathogen combat. However, such beneficial biological function comes with a trade-off. Instructed cDCs can prime T cell responses against harmless peripheral antigens when removing roadblocks of peripheral tolerance. Our data provide fresh insights into the evolutionary trade-offs that come with successful adaptation of vertebrates to their microbial environment.

AB - Environmental signals shape host physiology and fitness. Microbiota-derived cues are required to program conventional dendritic cells (cDCs) during the steady state so that they can promptly respond and initiate adaptive immune responses when encountering pathogens. However, the molecular underpinnings of microbiota-guided instructive programs are not well understood. Here, we report that the indigenous microbiota controls constitutive production of type I interferons (IFN-I) by plasmacytoid DCs. Using genome-wide analysis of transcriptional and epigenetic regulomes of cDCs from germ-free and IFN-I receptor (IFNAR)-deficient mice, we found that tonic IFNAR signaling instructs a specific epigenomic and metabolic basal state that poises cDCs for future pathogen combat. However, such beneficial biological function comes with a trade-off. Instructed cDCs can prime T cell responses against harmless peripheral antigens when removing roadblocks of peripheral tolerance. Our data provide fresh insights into the evolutionary trade-offs that come with successful adaptation of vertebrates to their microbial environment.

U2 - 10.1016/j.cell.2020.04.022

DO - 10.1016/j.cell.2020.04.022

M3 - SCORING: Journal article

C2 - 32380006

VL - 181

SP - 1080-1096.e19

JO - CELL

JF - CELL

SN - 0092-8674

IS - 5

ER -