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Microbiota-Dependent Effects of IL-22

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Microbiota-Dependent Effects of IL-22. / Sabihi, Morsal; Böttcher, Marius; Pelczar, Penelope; Huber, Samuel.

In: CELLS-BASEL, Vol. 9, No. 10, 29.09.2020, p. 2205.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Sabihi, M, Böttcher, M, Pelczar, P & Huber, S 2020, 'Microbiota-Dependent Effects of IL-22', CELLS-BASEL, vol. 9, no. 10, pp. 2205. https://doi.org/10.3390/cells9102205

APA

Sabihi, M., Böttcher, M., Pelczar, P., & Huber, S. (2020). Microbiota-Dependent Effects of IL-22. CELLS-BASEL, 9(10), 2205. https://doi.org/10.3390/cells9102205

Vancouver

Sabihi M, Böttcher M, Pelczar P, Huber S. Microbiota-Dependent Effects of IL-22. CELLS-BASEL. 2020 Sep 29;9(10):2205. https://doi.org/10.3390/cells9102205

Bibtex

@article{9d3b47aa38574c0cb8ba22c4f3b8b02c,
title = "Microbiota-Dependent Effects of IL-22",
abstract = "Cytokines are important contributors to immune responses against microbial and environmental threats and are of particular importance at epithelial barriers. These interfaces are continuously exposed to external factors and thus require immune components to both protect the host from pathogen invasion and to regulate overt inflammation. Recently, substantial efforts have been devoted to understanding how cytokines act on certain cells at barrier sites, and why the dysregulation of immune responses may lead to pathogenesis. In particular, the cytokine IL-22 is involved in preserving an intact epithelium, maintaining a balanced microbiota and a functioning defense system against external threats. However, a tight regulation of IL-22 is generally needed, since uncontrolled IL-22 production can lead to the progression of autoimmunity and cancer. Our aim in this review is to summarize novel findings on IL-22 and its interactions with specific microbial stimuli, and subsequently, to understand their contributions to the function of IL-22 and the clinical outcome. We particularly focus on understanding the detrimental effects of dysregulated control of IL-22 in certain disease contexts.",
author = "Morsal Sabihi and Marius B{\"o}ttcher and Penelope Pelczar and Samuel Huber",
year = "2020",
month = sep,
day = "29",
doi = "10.3390/cells9102205",
language = "English",
volume = "9",
pages = "2205",
journal = "CELLS-BASEL",
issn = "2073-4409",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "10",

}

RIS

TY - JOUR

T1 - Microbiota-Dependent Effects of IL-22

AU - Sabihi, Morsal

AU - Böttcher, Marius

AU - Pelczar, Penelope

AU - Huber, Samuel

PY - 2020/9/29

Y1 - 2020/9/29

N2 - Cytokines are important contributors to immune responses against microbial and environmental threats and are of particular importance at epithelial barriers. These interfaces are continuously exposed to external factors and thus require immune components to both protect the host from pathogen invasion and to regulate overt inflammation. Recently, substantial efforts have been devoted to understanding how cytokines act on certain cells at barrier sites, and why the dysregulation of immune responses may lead to pathogenesis. In particular, the cytokine IL-22 is involved in preserving an intact epithelium, maintaining a balanced microbiota and a functioning defense system against external threats. However, a tight regulation of IL-22 is generally needed, since uncontrolled IL-22 production can lead to the progression of autoimmunity and cancer. Our aim in this review is to summarize novel findings on IL-22 and its interactions with specific microbial stimuli, and subsequently, to understand their contributions to the function of IL-22 and the clinical outcome. We particularly focus on understanding the detrimental effects of dysregulated control of IL-22 in certain disease contexts.

AB - Cytokines are important contributors to immune responses against microbial and environmental threats and are of particular importance at epithelial barriers. These interfaces are continuously exposed to external factors and thus require immune components to both protect the host from pathogen invasion and to regulate overt inflammation. Recently, substantial efforts have been devoted to understanding how cytokines act on certain cells at barrier sites, and why the dysregulation of immune responses may lead to pathogenesis. In particular, the cytokine IL-22 is involved in preserving an intact epithelium, maintaining a balanced microbiota and a functioning defense system against external threats. However, a tight regulation of IL-22 is generally needed, since uncontrolled IL-22 production can lead to the progression of autoimmunity and cancer. Our aim in this review is to summarize novel findings on IL-22 and its interactions with specific microbial stimuli, and subsequently, to understand their contributions to the function of IL-22 and the clinical outcome. We particularly focus on understanding the detrimental effects of dysregulated control of IL-22 in certain disease contexts.

U2 - 10.3390/cells9102205

DO - 10.3390/cells9102205

M3 - SCORING: Review article

C2 - 33003458

VL - 9

SP - 2205

JO - CELLS-BASEL

JF - CELLS-BASEL

SN - 2073-4409

IS - 10

ER -