Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus.

  • B C Sondergaard
  • Philip Catalá-Lehnen
  • Antje K. Hübner
  • A-C Bay-Jensen
  • Thorsten Schinke
  • K Henriksen
  • Arndt Schilling
  • M Haberland
  • R H Nielsen
  • Michael Amling
  • M A Karsdal

Abstract

Calcitonin is well-known for its inhibitory actions on bone-resorbing osteoclasts and recently potential beneficial effects on cartilage were shown. We investigated effects of salmon calcitonin (sCT) on the articular cartilage and bone, after destabilization of the medial meniscus (DMM) in normal and sCT over-expressing mice.

Bibliographical data

Original languageEnglish
Article number2
ISSN1063-4584
Publication statusPublished - 2012
pubmed 22122987