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Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin

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Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. / Montag, D; Giese, K P; Bartsch, U; Martini, R; Lang, Y; Blüthmann, H; Karthigasan, J; Kirschner, D A; Wintergerst, E S; Nave, K A.

In: NEURON, Vol. 13, No. 1, 07.1994, p. 229-46.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Montag, D, Giese, KP, Bartsch, U, Martini, R, Lang, Y, Blüthmann, H, Karthigasan, J, Kirschner, DA, Wintergerst, ES & Nave, KA 1994, 'Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin', NEURON, vol. 13, no. 1, pp. 229-46.

APA

Montag, D., Giese, K. P., Bartsch, U., Martini, R., Lang, Y., Blüthmann, H., Karthigasan, J., Kirschner, D. A., Wintergerst, E. S., & Nave, K. A. (1994). Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. NEURON, 13(1), 229-46.

Vancouver

Montag D, Giese KP, Bartsch U, Martini R, Lang Y, Blüthmann H et al. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. NEURON. 1994 Jul;13(1):229-46.

Bibtex

@article{bd6ce4d578e84383b88921a102ee6331,
title = "Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin",
abstract = "Using homologous recombination in embryonic stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation. MAG-deficient mice appeared normal in motor coordination and spatial learning tasks. Normal myelin structure and nerve conduction in the PNS, with N-CAM overexpression at sites normally expressing MAG, suggested compensatory mechanisms. In the CNS, the onset of myelination was delayed, and subtle morphological abnormalities were detected in that the content of oligodendrocyte cytoplasm at the inner aspect of most myelin sheaths was reduced and that some axons were surrounded by two or more myelin sheaths. These observations suggest that MAG participates in the formation of the periaxonal cytoplasmic collar of oligodendrocytes and in the recognition between oligodendrocyte processes and axons.",
keywords = "Animals, Base Sequence, Behavior, Animal, Brain, Cell Adhesion Molecules, Neuronal, DNA, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Molecular Sequence Data, Mutation, Myelin Proteins, Myelin Sheath, Myelin-Associated Glycoprotein, Oligodendroglia, Optic Nerve, Peripheral Nerves, RNA, Messenger, Restriction Mapping, Schwann Cells, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",
author = "D Montag and Giese, {K P} and U Bartsch and R Martini and Y Lang and H Bl{\"u}thmann and J Karthigasan and Kirschner, {D A} and Wintergerst, {E S} and Nave, {K A}",
year = "1994",
month = jul,
language = "English",
volume = "13",
pages = "229--46",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin

AU - Montag, D

AU - Giese, K P

AU - Bartsch, U

AU - Martini, R

AU - Lang, Y

AU - Blüthmann, H

AU - Karthigasan, J

AU - Kirschner, D A

AU - Wintergerst, E S

AU - Nave, K A

PY - 1994/7

Y1 - 1994/7

N2 - Using homologous recombination in embryonic stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation. MAG-deficient mice appeared normal in motor coordination and spatial learning tasks. Normal myelin structure and nerve conduction in the PNS, with N-CAM overexpression at sites normally expressing MAG, suggested compensatory mechanisms. In the CNS, the onset of myelination was delayed, and subtle morphological abnormalities were detected in that the content of oligodendrocyte cytoplasm at the inner aspect of most myelin sheaths was reduced and that some axons were surrounded by two or more myelin sheaths. These observations suggest that MAG participates in the formation of the periaxonal cytoplasmic collar of oligodendrocytes and in the recognition between oligodendrocyte processes and axons.

AB - Using homologous recombination in embryonic stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation. MAG-deficient mice appeared normal in motor coordination and spatial learning tasks. Normal myelin structure and nerve conduction in the PNS, with N-CAM overexpression at sites normally expressing MAG, suggested compensatory mechanisms. In the CNS, the onset of myelination was delayed, and subtle morphological abnormalities were detected in that the content of oligodendrocyte cytoplasm at the inner aspect of most myelin sheaths was reduced and that some axons were surrounded by two or more myelin sheaths. These observations suggest that MAG participates in the formation of the periaxonal cytoplasmic collar of oligodendrocytes and in the recognition between oligodendrocyte processes and axons.

KW - Animals

KW - Base Sequence

KW - Behavior, Animal

KW - Brain

KW - Cell Adhesion Molecules, Neuronal

KW - DNA

KW - Female

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Microscopy, Electron

KW - Molecular Sequence Data

KW - Mutation

KW - Myelin Proteins

KW - Myelin Sheath

KW - Myelin-Associated Glycoprotein

KW - Oligodendroglia

KW - Optic Nerve

KW - Peripheral Nerves

KW - RNA, Messenger

KW - Restriction Mapping

KW - Schwann Cells

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

M3 - SCORING: Journal article

C2 - 7519026

VL - 13

SP - 229

EP - 246

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 1

ER -