MHC II molecules in inflammatory diseases: interplay of qualities and quantities.
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MHC II molecules in inflammatory diseases: interplay of qualities and quantities. / Friese, Manuel A.; Jones, E Yvonne; Fugger, Lars.
In: TRENDS IMMUNOL, Vol. 26, No. 11, 11, 2005, p. 559-561.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - MHC II molecules in inflammatory diseases: interplay of qualities and quantities.
AU - Friese, Manuel A.
AU - Jones, E Yvonne
AU - Fugger, Lars
PY - 2005
Y1 - 2005
N2 - It is generally accepted that MHC II molecules confer susceptibility to inflammatory diseases because of the different abilities they possess for binding and presenting peptides to T cells. A new study suggests that the level of MHC II gene expression is also a risk factor for such diseases. It shows that a polymorphism in the promoter of the MHC II transactivator (MHC2TA) gene (which encodes CIITA), leads to reduced MHC2TA expression, and hence reduced production of MHC II molecules. This predisposes to rheumatoid arthritis, multiple sclerosis and myocardial infarction.
AB - It is generally accepted that MHC II molecules confer susceptibility to inflammatory diseases because of the different abilities they possess for binding and presenting peptides to T cells. A new study suggests that the level of MHC II gene expression is also a risk factor for such diseases. It shows that a polymorphism in the promoter of the MHC II transactivator (MHC2TA) gene (which encodes CIITA), leads to reduced MHC2TA expression, and hence reduced production of MHC II molecules. This predisposes to rheumatoid arthritis, multiple sclerosis and myocardial infarction.
M3 - SCORING: Zeitschriftenaufsatz
VL - 26
SP - 559
EP - 561
JO - TRENDS IMMUNOL
JF - TRENDS IMMUNOL
SN - 1471-4906
IS - 11
M1 - 11
ER -
