Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells
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Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells : A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease. / van der Ven, Amelie T; Pape, Julius C; Hermann, Dirk; Schloesser, Robert; Genius, Just; Fischer, Nadine; Mößner, Rainald; Scherbaum, Norbert; Wiltfang, Jens; Rujescu, Dan; Benninghoff, Jens.
In: J ALZHEIMERS DIS, Vol. 57, No. 2, 2017, p. 531-540.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells
T2 - A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease
AU - van der Ven, Amelie T
AU - Pape, Julius C
AU - Hermann, Dirk
AU - Schloesser, Robert
AU - Genius, Just
AU - Fischer, Nadine
AU - Mößner, Rainald
AU - Scherbaum, Norbert
AU - Wiltfang, Jens
AU - Rujescu, Dan
AU - Benninghoff, Jens
PY - 2017
Y1 - 2017
N2 - An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay. To our knowledge, this is the first time that MB could be associated with neural mobility. The results of this study add insight to the spectrum of features of MB within the central nervous system and may be helpful for understanding the molecular mechanisms underlying a potential therapeutic effect of MB.
AB - An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay. To our knowledge, this is the first time that MB could be associated with neural mobility. The results of this study add insight to the spectrum of features of MB within the central nervous system and may be helpful for understanding the molecular mechanisms underlying a potential therapeutic effect of MB.
KW - Adult Stem Cells/cytology
KW - Animals
KW - Cell Movement/drug effects
KW - Cells, Cultured
KW - Central Nervous System Agents/pharmacology
KW - Dentate Gyrus/cytology
KW - Gene Expression/drug effects
KW - Immunohistochemistry
KW - Methylene Blue/pharmacology
KW - Mice
KW - Neural Stem Cells/cytology
KW - Time Factors
U2 - 10.3233/JAD-160755
DO - 10.3233/JAD-160755
M3 - SCORING: Journal article
C2 - 28269766
VL - 57
SP - 531
EP - 540
JO - J ALZHEIMERS DIS
JF - J ALZHEIMERS DIS
SN - 1387-2877
IS - 2
ER -
