Metastasiertes kastrationsresistentes Prostatakarzinom
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Metastasiertes kastrationsresistentes Prostatakarzinom : Neues zu Cabazitaxel unter Berücksichtigung der aktuellen Datenlage. / Gschwend, J E; Albers, P; Bögemann, M; Goebell, P; Heidenreich, A; Klier, J; König, F; Machtens, S; Pantel, K; Thomas, C.
In: UROLOGE, Vol. 57, No. 1, 01.2018, p. 34-39.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Metastasiertes kastrationsresistentes Prostatakarzinom
T2 - Neues zu Cabazitaxel unter Berücksichtigung der aktuellen Datenlage
AU - Gschwend, J E
AU - Albers, P
AU - Bögemann, M
AU - Goebell, P
AU - Heidenreich, A
AU - Klier, J
AU - König, F
AU - Machtens, S
AU - Pantel, K
AU - Thomas, C
PY - 2018/1
Y1 - 2018/1
N2 - BACKGROUND: At the 2016 ASCO annual meeting, new data from two randomized phase III studies concerning taxane-based chemotherapy as a treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC) were presented.OBJECTIVES: The focus is on the clinical impact of these data.MATERIALS AND METHODS: A group of German experts in the field of urogenital-oncologic expertise discussed the clinical impact with respect to the current data.RESULTS: The study results support the current clinical data. They confirm the efficacy and safety of cabazitaxel beyond first-line therapy with docetaxel for patients with mCRPC.CONCLUSIONS: Cabazitaxel is an important treatment option after docetaxel progression. With respect to the performance status of a patient, it is adequate to reduce the dosage to 20 mg/m2 cabazitaxel.
AB - BACKGROUND: At the 2016 ASCO annual meeting, new data from two randomized phase III studies concerning taxane-based chemotherapy as a treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC) were presented.OBJECTIVES: The focus is on the clinical impact of these data.MATERIALS AND METHODS: A group of German experts in the field of urogenital-oncologic expertise discussed the clinical impact with respect to the current data.RESULTS: The study results support the current clinical data. They confirm the efficacy and safety of cabazitaxel beyond first-line therapy with docetaxel for patients with mCRPC.CONCLUSIONS: Cabazitaxel is an important treatment option after docetaxel progression. With respect to the performance status of a patient, it is adequate to reduce the dosage to 20 mg/m2 cabazitaxel.
KW - English Abstract
KW - Journal Article
U2 - 10.1007/s00120-017-0533-y
DO - 10.1007/s00120-017-0533-y
M3 - SCORING: Zeitschriftenaufsatz
C2 - 29071398
VL - 57
SP - 34
EP - 39
JO - UROLOGE
JF - UROLOGE
SN - 0340-2592
IS - 1
ER -