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Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

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Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. / Bis, Joshua C; Kavousi, Maryam; Franceschini, Nora; Isaacs, Aaron; Abecasis, Gonçalo R; Schminke, Ulf; Post, Wendy S; Smith, Albert V; Cupples, L Adrienne; Markus, Hugh S; Schmidt, Reinhold; Huffman, Jennifer E; Lehtimäki, Terho; Baumert, Jens; Münzel, Thomas; Heckbert, Susan R; Dehghan, Abbas; North, Kari; Oostra, Ben; Bevan, Steve; Stoegerer, Eva-Maria; Hayward, Caroline; Raitakari, Olli; Meisinger, Christa; Schillert, Arne; Sanna, Serena; Völzke, Henry; Cheng, Yu-Ching; Thorsson, Bolli; Fox, Caroline S; Rice, Kenneth; Rivadeneira, Fernando; Nambi, Vijay; Halperin, Eran; Petrovic, Katja E; Peltonen, Leena; Wichmann, H Erich; Schnabel, Renate B; Dörr, Marcus; Parsa, Afshin; Aspelund, Thor; Demissie, Serkalem; Kathiresan, Sekar; Reilly, Muredach P; Taylor, Kent; Uitterlinden, Andre; Couper, David J; Sitzer, Matthias; Kähönen, Mika; Illig, Thomas; Wild, Philipp S; Orru, Marco; Lüdemann, Jan; Shuldiner, Alan R; Eiriksdottir, Gudny; White, Charles C; Rotter, Jerome I; Hofman, Albert; Seissler, Jochen; Zeller, Tanja; Usala, Gianluca; Ernst, Florian; Launer, Lenore J; D'Agostino, Ralph B; O'Leary, Daniel H; Ballantyne, Christie; Thiery, Joachim; Ziegler, Andreas; Lakatta, Edward G; Chilukoti, Ravi Kumar; Harris, Tamara B; Wolf, Philip A; Psaty, Bruce M; Polak, Joseph F; Li, Xia; Rathmann, Wolfgang; Uda, Manuela; Boerwinkle, Eric; Klopp, Norman; Schmidt, Helena; Wilson, James F; Viikari, Jorma; Koenig, Wolfgang; Blankenberg, Stefan; Newman, Anne B; Witteman, Jacqueline; Heiss, Gerardo; Duijn, Cornelia van; Scuteri, Angelo; Homuth, Georg; Mitchell, Braxton D; Gudnason, Vilmundur; O'Donnell, Christopher J; CARDIoGRAM Consortium.

In: NAT GENET, Vol. 43, No. 10, 11.09.2011, p. 940-947.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bis, JC, Kavousi, M, Franceschini, N, Isaacs, A, Abecasis, GR, Schminke, U, Post, WS, Smith, AV, Cupples, LA, Markus, HS, Schmidt, R, Huffman, JE, Lehtimäki, T, Baumert, J, Münzel, T, Heckbert, SR, Dehghan, A, North, K, Oostra, B, Bevan, S, Stoegerer, E-M, Hayward, C, Raitakari, O, Meisinger, C, Schillert, A, Sanna, S, Völzke, H, Cheng, Y-C, Thorsson, B, Fox, CS, Rice, K, Rivadeneira, F, Nambi, V, Halperin, E, Petrovic, KE, Peltonen, L, Wichmann, HE, Schnabel, RB, Dörr, M, Parsa, A, Aspelund, T, Demissie, S, Kathiresan, S, Reilly, MP, Taylor, K, Uitterlinden, A, Couper, DJ, Sitzer, M, Kähönen, M, Illig, T, Wild, PS, Orru, M, Lüdemann, J, Shuldiner, AR, Eiriksdottir, G, White, CC, Rotter, JI, Hofman, A, Seissler, J, Zeller, T, Usala, G, Ernst, F, Launer, LJ, D'Agostino, RB, O'Leary, DH, Ballantyne, C, Thiery, J, Ziegler, A, Lakatta, EG, Chilukoti, RK, Harris, TB, Wolf, PA, Psaty, BM, Polak, JF, Li, X, Rathmann, W, Uda, M, Boerwinkle, E, Klopp, N, Schmidt, H, Wilson, JF, Viikari, J, Koenig, W, Blankenberg, S, Newman, AB, Witteman, J, Heiss, G, Duijn, CV, Scuteri, A, Homuth, G, Mitchell, BD, Gudnason, V, O'Donnell, CJ & CARDIoGRAM Consortium 2011, 'Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque', NAT GENET, vol. 43, no. 10, pp. 940-947. https://doi.org/10.1038/ng.920

APA

Bis, J. C., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, G. R., Schminke, U., Post, W. S., Smith, A. V., Cupples, L. A., Markus, H. S., Schmidt, R., Huffman, J. E., Lehtimäki, T., Baumert, J., Münzel, T., Heckbert, S. R., Dehghan, A., North, K., Oostra, B., ... CARDIoGRAM Consortium (2011). Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. NAT GENET, 43(10), 940-947. https://doi.org/10.1038/ng.920

Vancouver

Bis JC, Kavousi M, Franceschini N, Isaacs A, Abecasis GR, Schminke U et al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. NAT GENET. 2011 Sep 11;43(10):940-947. https://doi.org/10.1038/ng.920

Bibtex

@article{0535a22d40fd4081b0dee9eab7f8ad12,
title = "Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque",
abstract = "Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.",
keywords = "Adult, Aged, Aging/genetics, Atherosclerosis/genetics, Carotid Intima-Media Thickness, Cohort Studies, Coronary Artery Disease/genetics, European Continental Ancestry Group/genetics, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Genotype, Heart/physiopathology, Humans, Middle Aged, Phenotype, Plaque, Atherosclerotic/genetics, Polymorphism, Single Nucleotide, Risk Factors",
author = "Bis, {Joshua C} and Maryam Kavousi and Nora Franceschini and Aaron Isaacs and Abecasis, {Gon{\c c}alo R} and Ulf Schminke and Post, {Wendy S} and Smith, {Albert V} and Cupples, {L Adrienne} and Markus, {Hugh S} and Reinhold Schmidt and Huffman, {Jennifer E} and Terho Lehtim{\"a}ki and Jens Baumert and Thomas M{\"u}nzel and Heckbert, {Susan R} and Abbas Dehghan and Kari North and Ben Oostra and Steve Bevan and Eva-Maria Stoegerer and Caroline Hayward and Olli Raitakari and Christa Meisinger and Arne Schillert and Serena Sanna and Henry V{\"o}lzke and Yu-Ching Cheng and Bolli Thorsson and Fox, {Caroline S} and Kenneth Rice and Fernando Rivadeneira and Vijay Nambi and Eran Halperin and Petrovic, {Katja E} and Leena Peltonen and Wichmann, {H Erich} and Schnabel, {Renate B} and Marcus D{\"o}rr and Afshin Parsa and Thor Aspelund and Serkalem Demissie and Sekar Kathiresan and Reilly, {Muredach P} and Kent Taylor and Andre Uitterlinden and Couper, {David J} and Matthias Sitzer and Mika K{\"a}h{\"o}nen and Thomas Illig and Wild, {Philipp S} and Marco Orru and Jan L{\"u}demann and Shuldiner, {Alan R} and Gudny Eiriksdottir and White, {Charles C} and Rotter, {Jerome I} and Albert Hofman and Jochen Seissler and Tanja Zeller and Gianluca Usala and Florian Ernst and Launer, {Lenore J} and D'Agostino, {Ralph B} and O'Leary, {Daniel H} and Christie Ballantyne and Joachim Thiery and Andreas Ziegler and Lakatta, {Edward G} and Chilukoti, {Ravi Kumar} and Harris, {Tamara B} and Wolf, {Philip A} and Psaty, {Bruce M} and Polak, {Joseph F} and Xia Li and Wolfgang Rathmann and Manuela Uda and Eric Boerwinkle and Norman Klopp and Helena Schmidt and Wilson, {James F} and Jorma Viikari and Wolfgang Koenig and Stefan Blankenberg and Newman, {Anne B} and Jacqueline Witteman and Gerardo Heiss and Duijn, {Cornelia van} and Angelo Scuteri and Georg Homuth and Mitchell, {Braxton D} and Vilmundur Gudnason and O'Donnell, {Christopher J} and {CARDIoGRAM Consortium}",
year = "2011",
month = sep,
day = "11",
doi = "10.1038/ng.920",
language = "English",
volume = "43",
pages = "940--947",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

AU - Bis, Joshua C

AU - Kavousi, Maryam

AU - Franceschini, Nora

AU - Isaacs, Aaron

AU - Abecasis, Gonçalo R

AU - Schminke, Ulf

AU - Post, Wendy S

AU - Smith, Albert V

AU - Cupples, L Adrienne

AU - Markus, Hugh S

AU - Schmidt, Reinhold

AU - Huffman, Jennifer E

AU - Lehtimäki, Terho

AU - Baumert, Jens

AU - Münzel, Thomas

AU - Heckbert, Susan R

AU - Dehghan, Abbas

AU - North, Kari

AU - Oostra, Ben

AU - Bevan, Steve

AU - Stoegerer, Eva-Maria

AU - Hayward, Caroline

AU - Raitakari, Olli

AU - Meisinger, Christa

AU - Schillert, Arne

AU - Sanna, Serena

AU - Völzke, Henry

AU - Cheng, Yu-Ching

AU - Thorsson, Bolli

AU - Fox, Caroline S

AU - Rice, Kenneth

AU - Rivadeneira, Fernando

AU - Nambi, Vijay

AU - Halperin, Eran

AU - Petrovic, Katja E

AU - Peltonen, Leena

AU - Wichmann, H Erich

AU - Schnabel, Renate B

AU - Dörr, Marcus

AU - Parsa, Afshin

AU - Aspelund, Thor

AU - Demissie, Serkalem

AU - Kathiresan, Sekar

AU - Reilly, Muredach P

AU - Taylor, Kent

AU - Uitterlinden, Andre

AU - Couper, David J

AU - Sitzer, Matthias

AU - Kähönen, Mika

AU - Illig, Thomas

AU - Wild, Philipp S

AU - Orru, Marco

AU - Lüdemann, Jan

AU - Shuldiner, Alan R

AU - Eiriksdottir, Gudny

AU - White, Charles C

AU - Rotter, Jerome I

AU - Hofman, Albert

AU - Seissler, Jochen

AU - Zeller, Tanja

AU - Usala, Gianluca

AU - Ernst, Florian

AU - Launer, Lenore J

AU - D'Agostino, Ralph B

AU - O'Leary, Daniel H

AU - Ballantyne, Christie

AU - Thiery, Joachim

AU - Ziegler, Andreas

AU - Lakatta, Edward G

AU - Chilukoti, Ravi Kumar

AU - Harris, Tamara B

AU - Wolf, Philip A

AU - Psaty, Bruce M

AU - Polak, Joseph F

AU - Li, Xia

AU - Rathmann, Wolfgang

AU - Uda, Manuela

AU - Boerwinkle, Eric

AU - Klopp, Norman

AU - Schmidt, Helena

AU - Wilson, James F

AU - Viikari, Jorma

AU - Koenig, Wolfgang

AU - Blankenberg, Stefan

AU - Newman, Anne B

AU - Witteman, Jacqueline

AU - Heiss, Gerardo

AU - Duijn, Cornelia van

AU - Scuteri, Angelo

AU - Homuth, Georg

AU - Mitchell, Braxton D

AU - Gudnason, Vilmundur

AU - O'Donnell, Christopher J

AU - CARDIoGRAM Consortium

PY - 2011/9/11

Y1 - 2011/9/11

N2 - Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.

AB - Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.

KW - Adult

KW - Aged

KW - Aging/genetics

KW - Atherosclerosis/genetics

KW - Carotid Intima-Media Thickness

KW - Cohort Studies

KW - Coronary Artery Disease/genetics

KW - European Continental Ancestry Group/genetics

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Genotype

KW - Heart/physiopathology

KW - Humans

KW - Middle Aged

KW - Phenotype

KW - Plaque, Atherosclerotic/genetics

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

U2 - 10.1038/ng.920

DO - 10.1038/ng.920

M3 - SCORING: Journal article

C2 - 21909108

VL - 43

SP - 940

EP - 947

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 10

ER -