Research ExplorerPublicationsMendelian Randomization of Circulating Polyunsaturated Fatty...

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk

Standard

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk. / Khankari, Nikhil K; Banbury, Barbara L; Borges, Maria C; Haycock, Philip; Albanes, Demetrius; Arndt, Volker; Berndt, Sonja I; Bézieau, Stéphane; Brenner, Hermann; Campbell, Peter T; Casey, Graham; Chan, Andrew T; Chang-Claude, Jenny; Conti, David V; Cotterchio, Michelle; English, Dallas R; Figueiredo, Jane C; Giles, Graham G; Giovannucci, Edward L; Gunter, Marc J; Hampe, Jochen; Hoffmeister, Michael; Hopper, John L; Jenkins, Mark A; Joshi, Amit D; Marchand, Loic Le; Lemire, Mathieu; Li, Christopher I; Li, Li; Lindblom, Annika; Martín, Vicente; Moreno, Victor; Newcomb, Polly A; Offit, Kenneth; Pharoah, Paul D P; Rennert, Gad; Sakoda, Lori C; Schafmayer, Clemens; Schmit, Stephanie L; Slattery, Martha L; Song, Mingyang; Thibodeau, Stephen N; Ulrich, Cornelia M; Weinstein, Stephanie J; White, Emily; Win, Aung Ko; Wolk, Alicja; Woods, Michael O; Wu, Anna H; Cai, Qiuyin; Denny, Joshua C; Edwards, Todd L; Murff, Harvey J; Gruber, Stephen B; Zheng, Wei.

In: CANCER EPIDEM BIOMAR, Vol. 29, No. 4, 04.2020, p. 860-870.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Khankari, NK, Banbury, BL, Borges, MC, Haycock, P, Albanes, D, Arndt, V, Berndt, SI, Bézieau, S, Brenner, H, Campbell, PT, Casey, G, Chan, AT, Chang-Claude, J, Conti, DV, Cotterchio, M, English, DR, Figueiredo, JC, Giles, GG, Giovannucci, EL, Gunter, MJ, Hampe, J, Hoffmeister, M, Hopper, JL, Jenkins, MA, Joshi, AD, Marchand, LL, Lemire, M, Li, CI, Li, L, Lindblom, A, Martín, V, Moreno, V, Newcomb, PA, Offit, K, Pharoah, PDP, Rennert, G, Sakoda, LC, Schafmayer, C, Schmit, SL, Slattery, ML, Song, M, Thibodeau, SN, Ulrich, CM, Weinstein, SJ, White, E, Win, AK, Wolk, A, Woods, MO, Wu, AH, Cai, Q, Denny, JC, Edwards, TL, Murff, HJ, Gruber, SB & Zheng, W 2020, 'Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk', CANCER EPIDEM BIOMAR, vol. 29, no. 4, pp. 860-870. https://doi.org/10.1158/1055-9965.EPI-19-0891

APA

Khankari, N. K., Banbury, B. L., Borges, M. C., Haycock, P., Albanes, D., Arndt, V., Berndt, S. I., Bézieau, S., Brenner, H., Campbell, P. T., Casey, G., Chan, A. T., Chang-Claude, J., Conti, D. V., Cotterchio, M., English, D. R., Figueiredo, J. C., Giles, G. G., Giovannucci, E. L., ... Zheng, W. (2020). Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk. CANCER EPIDEM BIOMAR, 29(4), 860-870. https://doi.org/10.1158/1055-9965.EPI-19-0891

Vancouver

Khankari NK, Banbury BL, Borges MC, Haycock P, Albanes D, Arndt V et al. Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk. CANCER EPIDEM BIOMAR. 2020 Apr;29(4):860-870. https://doi.org/10.1158/1055-9965.EPI-19-0891

Bibtex

@article{d5ea9e5d13044e4cb2cbc4fbcdb89ddf,
title = "Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk",
abstract = "BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsistent. Mendelian randomization may strengthen causal inference from observational studies. Given their shared metabolic pathway, examining the combined effects of aspirin/NSAID use with PUFAs could help elucidate an association between PUFAs and colorectal cancer risk.METHODS: Information was leveraged from genome-wide association studies (GWAS) regarding PUFA-associated SNPs to create weighted genetic scores (wGS) representing genetically predicted circulating blood PUFAs for 11,016 non-Hispanic white colorectal cancer cases and 13,732 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations per SD increase in the wGS were estimated using unconditional logistic regression. Interactions between PUFA wGSs and aspirin/NSAID use on colorectal cancer risk were also examined.RESULTS: Modest colorectal cancer risk reductions were observed per SD increase in circulating linoleic acid [ORLA = 0.96; 95% confidence interval (CI) = 0.93-0.98; P = 5.2 × 10-4] and α-linolenic acid (ORALA = 0.95; 95% CI = 0.92-0.97; P = 5.4 × 10-5), whereas modest increased risks were observed for arachidonic (ORAA = 1.06; 95% CI = 1.03-1.08; P = 3.3 × 10-5), eicosapentaenoic (OREPA = 1.04; 95% CI = 1.01-1.07; P = 2.5 × 10-3), and docosapentaenoic acids (ORDPA = 1.03; 95% CI = 1.01-1.06; P = 1.2 × 10-2). Each of these effects was stronger among aspirin/NSAID nonusers in the stratified analyses.CONCLUSIONS: Our study suggests that higher circulating shorter-chain PUFAs (i.e., LA and ALA) were associated with reduced colorectal cancer risk, whereas longer-chain PUFAs (i.e., AA, EPA, and DPA) were associated with an increased colorectal cancer risk.IMPACT: The interaction of PUFAs with aspirin/NSAID use indicates a shared colorectal cancer inflammatory pathway. Future research should continue to improve PUFA genetic instruments to elucidate the independent effects of PUFAs on colorectal cancer.",
author = "Khankari, {Nikhil K} and Banbury, {Barbara L} and Borges, {Maria C} and Philip Haycock and Demetrius Albanes and Volker Arndt and Berndt, {Sonja I} and St{\'e}phane B{\'e}zieau and Hermann Brenner and Campbell, {Peter T} and Graham Casey and Chan, {Andrew T} and Jenny Chang-Claude and Conti, {David V} and Michelle Cotterchio and English, {Dallas R} and Figueiredo, {Jane C} and Giles, {Graham G} and Giovannucci, {Edward L} and Gunter, {Marc J} and Jochen Hampe and Michael Hoffmeister and Hopper, {John L} and Jenkins, {Mark A} and Joshi, {Amit D} and Marchand, {Loic Le} and Mathieu Lemire and Li, {Christopher I} and Li Li and Annika Lindblom and Vicente Mart{\'i}n and Victor Moreno and Newcomb, {Polly A} and Kenneth Offit and Pharoah, {Paul D P} and Gad Rennert and Sakoda, {Lori C} and Clemens Schafmayer and Schmit, {Stephanie L} and Slattery, {Martha L} and Mingyang Song and Thibodeau, {Stephen N} and Ulrich, {Cornelia M} and Weinstein, {Stephanie J} and Emily White and Win, {Aung Ko} and Alicja Wolk and Woods, {Michael O} and Wu, {Anna H} and Qiuyin Cai and Denny, {Joshua C} and Edwards, {Todd L} and Murff, {Harvey J} and Gruber, {Stephen B} and Wei Zheng",
note = "{\textcopyright}2020 American Association for Cancer Research.",
year = "2020",
month = apr,
doi = "10.1158/1055-9965.EPI-19-0891",
language = "English",
volume = "29",
pages = "860--870",
journal = "CANCER EPIDEM BIOMAR",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk

AU - Khankari, Nikhil K

AU - Banbury, Barbara L

AU - Borges, Maria C

AU - Haycock, Philip

AU - Albanes, Demetrius

AU - Arndt, Volker

AU - Berndt, Sonja I

AU - Bézieau, Stéphane

AU - Brenner, Hermann

AU - Campbell, Peter T

AU - Casey, Graham

AU - Chan, Andrew T

AU - Chang-Claude, Jenny

AU - Conti, David V

AU - Cotterchio, Michelle

AU - English, Dallas R

AU - Figueiredo, Jane C

AU - Giles, Graham G

AU - Giovannucci, Edward L

AU - Gunter, Marc J

AU - Hampe, Jochen

AU - Hoffmeister, Michael

AU - Hopper, John L

AU - Jenkins, Mark A

AU - Joshi, Amit D

AU - Marchand, Loic Le

AU - Lemire, Mathieu

AU - Li, Christopher I

AU - Li, Li

AU - Lindblom, Annika

AU - Martín, Vicente

AU - Moreno, Victor

AU - Newcomb, Polly A

AU - Offit, Kenneth

AU - Pharoah, Paul D P

AU - Rennert, Gad

AU - Sakoda, Lori C

AU - Schafmayer, Clemens

AU - Schmit, Stephanie L

AU - Slattery, Martha L

AU - Song, Mingyang

AU - Thibodeau, Stephen N

AU - Ulrich, Cornelia M

AU - Weinstein, Stephanie J

AU - White, Emily

AU - Win, Aung Ko

AU - Wolk, Alicja

AU - Woods, Michael O

AU - Wu, Anna H

AU - Cai, Qiuyin

AU - Denny, Joshua C

AU - Edwards, Todd L

AU - Murff, Harvey J

AU - Gruber, Stephen B

AU - Zheng, Wei

N1 - ©2020 American Association for Cancer Research.

PY - 2020/4

Y1 - 2020/4

N2 - BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsistent. Mendelian randomization may strengthen causal inference from observational studies. Given their shared metabolic pathway, examining the combined effects of aspirin/NSAID use with PUFAs could help elucidate an association between PUFAs and colorectal cancer risk.METHODS: Information was leveraged from genome-wide association studies (GWAS) regarding PUFA-associated SNPs to create weighted genetic scores (wGS) representing genetically predicted circulating blood PUFAs for 11,016 non-Hispanic white colorectal cancer cases and 13,732 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations per SD increase in the wGS were estimated using unconditional logistic regression. Interactions between PUFA wGSs and aspirin/NSAID use on colorectal cancer risk were also examined.RESULTS: Modest colorectal cancer risk reductions were observed per SD increase in circulating linoleic acid [ORLA = 0.96; 95% confidence interval (CI) = 0.93-0.98; P = 5.2 × 10-4] and α-linolenic acid (ORALA = 0.95; 95% CI = 0.92-0.97; P = 5.4 × 10-5), whereas modest increased risks were observed for arachidonic (ORAA = 1.06; 95% CI = 1.03-1.08; P = 3.3 × 10-5), eicosapentaenoic (OREPA = 1.04; 95% CI = 1.01-1.07; P = 2.5 × 10-3), and docosapentaenoic acids (ORDPA = 1.03; 95% CI = 1.01-1.06; P = 1.2 × 10-2). Each of these effects was stronger among aspirin/NSAID nonusers in the stratified analyses.CONCLUSIONS: Our study suggests that higher circulating shorter-chain PUFAs (i.e., LA and ALA) were associated with reduced colorectal cancer risk, whereas longer-chain PUFAs (i.e., AA, EPA, and DPA) were associated with an increased colorectal cancer risk.IMPACT: The interaction of PUFAs with aspirin/NSAID use indicates a shared colorectal cancer inflammatory pathway. Future research should continue to improve PUFA genetic instruments to elucidate the independent effects of PUFAs on colorectal cancer.

AB - BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsistent. Mendelian randomization may strengthen causal inference from observational studies. Given their shared metabolic pathway, examining the combined effects of aspirin/NSAID use with PUFAs could help elucidate an association between PUFAs and colorectal cancer risk.METHODS: Information was leveraged from genome-wide association studies (GWAS) regarding PUFA-associated SNPs to create weighted genetic scores (wGS) representing genetically predicted circulating blood PUFAs for 11,016 non-Hispanic white colorectal cancer cases and 13,732 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations per SD increase in the wGS were estimated using unconditional logistic regression. Interactions between PUFA wGSs and aspirin/NSAID use on colorectal cancer risk were also examined.RESULTS: Modest colorectal cancer risk reductions were observed per SD increase in circulating linoleic acid [ORLA = 0.96; 95% confidence interval (CI) = 0.93-0.98; P = 5.2 × 10-4] and α-linolenic acid (ORALA = 0.95; 95% CI = 0.92-0.97; P = 5.4 × 10-5), whereas modest increased risks were observed for arachidonic (ORAA = 1.06; 95% CI = 1.03-1.08; P = 3.3 × 10-5), eicosapentaenoic (OREPA = 1.04; 95% CI = 1.01-1.07; P = 2.5 × 10-3), and docosapentaenoic acids (ORDPA = 1.03; 95% CI = 1.01-1.06; P = 1.2 × 10-2). Each of these effects was stronger among aspirin/NSAID nonusers in the stratified analyses.CONCLUSIONS: Our study suggests that higher circulating shorter-chain PUFAs (i.e., LA and ALA) were associated with reduced colorectal cancer risk, whereas longer-chain PUFAs (i.e., AA, EPA, and DPA) were associated with an increased colorectal cancer risk.IMPACT: The interaction of PUFAs with aspirin/NSAID use indicates a shared colorectal cancer inflammatory pathway. Future research should continue to improve PUFA genetic instruments to elucidate the independent effects of PUFAs on colorectal cancer.

U2 - 10.1158/1055-9965.EPI-19-0891

DO - 10.1158/1055-9965.EPI-19-0891

M3 - SCORING: Journal article

C2 - 32051193

VL - 29

SP - 860

EP - 870

JO - CANCER EPIDEM BIOMAR

JF - CANCER EPIDEM BIOMAR

SN - 1055-9965

IS - 4

ER -