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Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment

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Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment. / Wolfsgruber, Steffen; Wagner, Michael; Schmidtke, Klaus; Frölich, Lutz; Kurz, Alexander; Schulz, Stefanie; Hampel, Harald; Heuser, Isabella; Peters, Oliver; Reischies, Friedel M; Jahn, Holger; Luckhaus, Christian; Hüll, Michael; Gertz, Hermann-Josef; Schröder, Johannes; Pantel, Johannes; Rienhoff, Otto; Rüther, Eckart; Henn, Fritz; Wiltfang, Jens; Maier, Wolfgang; Kornhuber, Johannes; Jessen, Frank.

In: PLOS ONE, Vol. 9, No. 7, 14.07.2014, p. e100812.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wolfsgruber, S, Wagner, M, Schmidtke, K, Frölich, L, Kurz, A, Schulz, S, Hampel, H, Heuser, I, Peters, O, Reischies, FM, Jahn, H, Luckhaus, C, Hüll, M, Gertz, H-J, Schröder, J, Pantel, J, Rienhoff, O, Rüther, E, Henn, F, Wiltfang, J, Maier, W, Kornhuber, J & Jessen, F 2014, 'Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment', PLOS ONE, vol. 9, no. 7, pp. e100812. https://doi.org/10.1371/journal.pone.0100812

APA

Wolfsgruber, S., Wagner, M., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H-J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., ... Jessen, F. (2014). Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment. PLOS ONE, 9(7), e100812. https://doi.org/10.1371/journal.pone.0100812

Vancouver

Wolfsgruber S, Wagner M, Schmidtke K, Frölich L, Kurz A, Schulz S et al. Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment. PLOS ONE. 2014 Jul 14;9(7):e100812. https://doi.org/10.1371/journal.pone.0100812

Bibtex

@article{829521bd618a4700b01ca3fddd3a79d9,
title = "Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment",
abstract = "BACKGROUND: Concerns about worsening memory ({"}memory concerns{"}; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI).METHODS: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.RESULTS: Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33-4.89), lower memory performance (HR = 0.63, 95%CI: 0.56-0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18-3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.CONCLUSIONS: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.",
author = "Steffen Wolfsgruber and Michael Wagner and Klaus Schmidtke and Lutz Fr{\"o}lich and Alexander Kurz and Stefanie Schulz and Harald Hampel and Isabella Heuser and Oliver Peters and Reischies, {Friedel M} and Holger Jahn and Christian Luckhaus and Michael H{\"u}ll and Hermann-Josef Gertz and Johannes Schr{\"o}der and Johannes Pantel and Otto Rienhoff and Eckart R{\"u}ther and Fritz Henn and Jens Wiltfang and Wolfgang Maier and Johannes Kornhuber and Frank Jessen",
year = "2014",
month = jul,
day = "14",
doi = "10.1371/journal.pone.0100812",
language = "English",
volume = "9",
pages = "e100812",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment

AU - Wolfsgruber, Steffen

AU - Wagner, Michael

AU - Schmidtke, Klaus

AU - Frölich, Lutz

AU - Kurz, Alexander

AU - Schulz, Stefanie

AU - Hampel, Harald

AU - Heuser, Isabella

AU - Peters, Oliver

AU - Reischies, Friedel M

AU - Jahn, Holger

AU - Luckhaus, Christian

AU - Hüll, Michael

AU - Gertz, Hermann-Josef

AU - Schröder, Johannes

AU - Pantel, Johannes

AU - Rienhoff, Otto

AU - Rüther, Eckart

AU - Henn, Fritz

AU - Wiltfang, Jens

AU - Maier, Wolfgang

AU - Kornhuber, Johannes

AU - Jessen, Frank

PY - 2014/7/14

Y1 - 2014/7/14

N2 - BACKGROUND: Concerns about worsening memory ("memory concerns"; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI).METHODS: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.RESULTS: Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33-4.89), lower memory performance (HR = 0.63, 95%CI: 0.56-0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18-3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.CONCLUSIONS: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.

AB - BACKGROUND: Concerns about worsening memory ("memory concerns"; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI).METHODS: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.RESULTS: Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33-4.89), lower memory performance (HR = 0.63, 95%CI: 0.56-0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18-3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.CONCLUSIONS: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.

U2 - 10.1371/journal.pone.0100812

DO - 10.1371/journal.pone.0100812

M3 - SCORING: Journal article

C2 - 25019225

VL - 9

SP - e100812

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 7

ER -