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Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research

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Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. / Grupp, Katharina; Erbes, Johannes; Poppe, Annika; Wodack, Karin; Gocht, Andreas; Trepte, Constantin; Havel, Jan; Mann, Oliver; Izbicki, Jakob R; Bachmann, Kai.

In: WORLD J EMERG SURG, Vol. 14, 2019, p. 18.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grupp, K, Erbes, J, Poppe, A, Wodack, K, Gocht, A, Trepte, C, Havel, J, Mann, O, Izbicki, JR & Bachmann, K 2019, 'Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research', WORLD J EMERG SURG, vol. 14, pp. 18. https://doi.org/10.1186/s13017-019-0237-2

APA

Grupp, K., Erbes, J., Poppe, A., Wodack, K., Gocht, A., Trepte, C., Havel, J., Mann, O., Izbicki, J. R., & Bachmann, K. (2019). Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. WORLD J EMERG SURG, 14, 18. https://doi.org/10.1186/s13017-019-0237-2

Vancouver

Grupp K, Erbes J, Poppe A, Wodack K, Gocht A, Trepte C et al. Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. WORLD J EMERG SURG. 2019;14:18. https://doi.org/10.1186/s13017-019-0237-2

Bibtex

@article{deecafd014d74f8b91cde0dec79f894a,
title = "Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research",
abstract = "Background: Severe acute pancreatitis is associated with high morbidity and mortality. Melatonin is known as the activator of antioxidant enzymes. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis.Methods: In this study, acute pancreatitis was induced in 38 German domestic pigs (German Hybrid). After induction of acute pancreatitis, 18 animals were treated with melatonin. Intraoperative clinical data, postoperative blood parameters, fitness, and Porcine Well-being (PWB) score, and post-mortal histopathological data were analyzed in both study groups.Results: The matching procedure created two groups (melatonin group and control group) which were very similar. The fitness and PWB score were postoperative significantly enhanced in the melatonin group as compared to the control group (p = 0.005 and p = 0.003). Additionally, histological analysis revealed that acinar necrosis, fat tissue necrosis, and edema were significantly reduced in the melatonin group as compared to the non-melatonin group (p = 0.025, p = 0.003, and p = 0.028).Conclusions: Pigs, which were treated with melatonin, were characterized by higher fitness and PWB scores than those of the control group. Moreover, melatonin treatment reduces the acinar necrosis, fat tissue necrosis, and edema of pancreatic tissue. Thus, melatonin might be a useful therapeutic option in severe acute pancreatitis.",
keywords = "Journal Article",
author = "Katharina Grupp and Johannes Erbes and Annika Poppe and Karin Wodack and Andreas Gocht and Constantin Trepte and Jan Havel and Oliver Mann and Izbicki, {Jakob R} and Kai Bachmann",
year = "2019",
doi = "10.1186/s13017-019-0237-2",
language = "English",
volume = "14",
pages = "18",
journal = "WORLD J EMERG SURG",
issn = "1749-7922",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research

AU - Grupp, Katharina

AU - Erbes, Johannes

AU - Poppe, Annika

AU - Wodack, Karin

AU - Gocht, Andreas

AU - Trepte, Constantin

AU - Havel, Jan

AU - Mann, Oliver

AU - Izbicki, Jakob R

AU - Bachmann, Kai

PY - 2019

Y1 - 2019

N2 - Background: Severe acute pancreatitis is associated with high morbidity and mortality. Melatonin is known as the activator of antioxidant enzymes. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis.Methods: In this study, acute pancreatitis was induced in 38 German domestic pigs (German Hybrid). After induction of acute pancreatitis, 18 animals were treated with melatonin. Intraoperative clinical data, postoperative blood parameters, fitness, and Porcine Well-being (PWB) score, and post-mortal histopathological data were analyzed in both study groups.Results: The matching procedure created two groups (melatonin group and control group) which were very similar. The fitness and PWB score were postoperative significantly enhanced in the melatonin group as compared to the control group (p = 0.005 and p = 0.003). Additionally, histological analysis revealed that acinar necrosis, fat tissue necrosis, and edema were significantly reduced in the melatonin group as compared to the non-melatonin group (p = 0.025, p = 0.003, and p = 0.028).Conclusions: Pigs, which were treated with melatonin, were characterized by higher fitness and PWB scores than those of the control group. Moreover, melatonin treatment reduces the acinar necrosis, fat tissue necrosis, and edema of pancreatic tissue. Thus, melatonin might be a useful therapeutic option in severe acute pancreatitis.

AB - Background: Severe acute pancreatitis is associated with high morbidity and mortality. Melatonin is known as the activator of antioxidant enzymes. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis.Methods: In this study, acute pancreatitis was induced in 38 German domestic pigs (German Hybrid). After induction of acute pancreatitis, 18 animals were treated with melatonin. Intraoperative clinical data, postoperative blood parameters, fitness, and Porcine Well-being (PWB) score, and post-mortal histopathological data were analyzed in both study groups.Results: The matching procedure created two groups (melatonin group and control group) which were very similar. The fitness and PWB score were postoperative significantly enhanced in the melatonin group as compared to the control group (p = 0.005 and p = 0.003). Additionally, histological analysis revealed that acinar necrosis, fat tissue necrosis, and edema were significantly reduced in the melatonin group as compared to the non-melatonin group (p = 0.025, p = 0.003, and p = 0.028).Conclusions: Pigs, which were treated with melatonin, were characterized by higher fitness and PWB scores than those of the control group. Moreover, melatonin treatment reduces the acinar necrosis, fat tissue necrosis, and edema of pancreatic tissue. Thus, melatonin might be a useful therapeutic option in severe acute pancreatitis.

KW - Journal Article

U2 - 10.1186/s13017-019-0237-2

DO - 10.1186/s13017-019-0237-2

M3 - SCORING: Journal article

C2 - 31007709

VL - 14

SP - 18

JO - WORLD J EMERG SURG

JF - WORLD J EMERG SURG

SN - 1749-7922

ER -