MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.
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MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. / Markowski, Dominique Nadine; Huhle, Sonja; Nimzyk, Rolf; Stenman, Göran; Löning, Thomas; Bullerdiek, Jörn.
In: GENE CHROMOSOME CANC, Vol. 52, No. 3, 3, 2013, p. 297-304.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.
AU - Markowski, Dominique Nadine
AU - Huhle, Sonja
AU - Nimzyk, Rolf
AU - Stenman, Göran
AU - Löning, Thomas
AU - Bullerdiek, Jörn
PY - 2013
Y1 - 2013
N2 - Mutations of the mediator subcomplex 12 gene (MED12) recently have been described in a large group of uterine leiomyomas (UL) but only in a single malignant uterine smooth muscle tumor. To further address the occurrence of fibroid-type MED12 mutations in smooth muscle tumors, we have analyzed samples from 34 leiomyosarcomas (LMS), 21 UL, two extrauterine leiomyomas (EL), and 10 canine genital leiomyomas for the presence of MED12 mutations of the UL-type. Interestingly, besides UL MED12 mutations were found in one uterine LMS, one EL, and two canine vaginal leiomyomas. The results confirm the occurrence of fibroid-type MED12 mutations in malignant uterine smooth muscle tumors thus suggesting a rare but existing leiomyoma-LMS sequence. In addition, for the first time MED12 mutations are reported in smooth muscle tumors in a non-primate mammalian species.
AB - Mutations of the mediator subcomplex 12 gene (MED12) recently have been described in a large group of uterine leiomyomas (UL) but only in a single malignant uterine smooth muscle tumor. To further address the occurrence of fibroid-type MED12 mutations in smooth muscle tumors, we have analyzed samples from 34 leiomyosarcomas (LMS), 21 UL, two extrauterine leiomyomas (EL), and 10 canine genital leiomyomas for the presence of MED12 mutations of the UL-type. Interestingly, besides UL MED12 mutations were found in one uterine LMS, one EL, and two canine vaginal leiomyomas. The results confirm the occurrence of fibroid-type MED12 mutations in malignant uterine smooth muscle tumors thus suggesting a rare but existing leiomyoma-LMS sequence. In addition, for the first time MED12 mutations are reported in smooth muscle tumors in a non-primate mammalian species.
KW - Animals
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Dogs
KW - Base Sequence
KW - Gene Expression Regulation, Neoplastic
KW - Neoplasm Grading
KW - Mutation
KW - RNA, Messenger/genetics
KW - HMGA2 Protein/genetics
KW - Mediator Complex/genetics
KW - Breast Neoplasms/genetics/pathology
KW - Leiomyoma/genetics/pathology
KW - Leiomyosarcoma/genetics/pathology
KW - Mammary Neoplasms, Animal
KW - Smooth Muscle Tumor/genetics/pathology
KW - Animals
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Dogs
KW - Base Sequence
KW - Gene Expression Regulation, Neoplastic
KW - Neoplasm Grading
KW - Mutation
KW - RNA, Messenger/genetics
KW - HMGA2 Protein/genetics
KW - Mediator Complex/genetics
KW - Breast Neoplasms/genetics/pathology
KW - Leiomyoma/genetics/pathology
KW - Leiomyosarcoma/genetics/pathology
KW - Mammary Neoplasms, Animal
KW - Smooth Muscle Tumor/genetics/pathology
M3 - SCORING: Journal article
VL - 52
SP - 297
EP - 304
JO - GENE CHROMOSOME CANC
JF - GENE CHROMOSOME CANC
SN - 1045-2257
IS - 3
M1 - 3
ER -
