Mechanisms of in vivo anti-neuroblastoma activity of human natural IgM.
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Mechanisms of in vivo anti-neuroblastoma activity of human natural IgM. / Ollert, M W; David, K; Vollmert, C; Juhl, H; Erttmann, Rudolf; Bredehorst, R; Vogel, C W.
In: EUR J CANCER, Vol. 33, No. 12, 12, 1997, p. 1942-1948.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Mechanisms of in vivo anti-neuroblastoma activity of human natural IgM.
AU - Ollert, M W
AU - David, K
AU - Vollmert, C
AU - Juhl, H
AU - Erttmann, Rudolf
AU - Bredehorst, R
AU - Vogel, C W
PY - 1997
Y1 - 1997
N2 - Normal human sera of healthy adults contain natural IgM antibodies which are cytotoxic for human neuroblastoma cells. In this study, we evaluated the anti-neuroblastoma activity of these natural IgM antibodies in nude rats bearing solid human neuroblastoma tumours. A single intravenous (i.v.) injection of purified cytotoxic IgM led to uptake of IgM in the tumours with massive perivascular complement activation and accumulation of neutrophil granulocytes after 24 h. Five consecutive i.v. injections of purified cytotoxic IgM into neuroblastoma-bearing animals resulted in complete growth arrest of even large established solid tumours which lasted for several weeks after discontinuation of the injections, whereas tumours of control animals continued to grow exponentially during the observation period. These studies suggest that natural anti-neuroblastoma IgM may have a potential as a novel therapeutic modality in the treatment of human neuroblastoma.
AB - Normal human sera of healthy adults contain natural IgM antibodies which are cytotoxic for human neuroblastoma cells. In this study, we evaluated the anti-neuroblastoma activity of these natural IgM antibodies in nude rats bearing solid human neuroblastoma tumours. A single intravenous (i.v.) injection of purified cytotoxic IgM led to uptake of IgM in the tumours with massive perivascular complement activation and accumulation of neutrophil granulocytes after 24 h. Five consecutive i.v. injections of purified cytotoxic IgM into neuroblastoma-bearing animals resulted in complete growth arrest of even large established solid tumours which lasted for several weeks after discontinuation of the injections, whereas tumours of control animals continued to grow exponentially during the observation period. These studies suggest that natural anti-neuroblastoma IgM may have a potential as a novel therapeutic modality in the treatment of human neuroblastoma.
M3 - SCORING: Zeitschriftenaufsatz
VL - 33
SP - 1942
EP - 1948
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 12
M1 - 12
ER -
