Mechanisms and functions of IL-17 signaling in renal autoimmune diseases

Tilman Schmidt; Hans-Joachim Paust; Ulf Panzer

doi:10.1016/j.molimm.2018.09.005

Mechanisms and functions of IL-17 signaling in renal autoimmune diseases

Standard

Mechanisms and functions of IL-17 signaling in renal autoimmune diseases. / Schmidt, Tilman ; Paust, Hans-Joachim ; Panzer, Ulf.

In: MOL IMMUNOL, Vol. 104, 12.2018, p. 90-99.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Schmidt, T , Paust, H-J & Panzer, U 2018, 'Mechanisms and functions of IL-17 signaling in renal autoimmune diseases', MOL IMMUNOL, vol. 104, pp. 90-99. https://doi.org/10.1016/j.molimm.2018.09.005

APA

Schmidt, T., Paust, H-J., & Panzer, U. (2018). Mechanisms and functions of IL-17 signaling in renal autoimmune diseases. MOL IMMUNOL, 104, 90-99. https://doi.org/10.1016/j.molimm.2018.09.005

Vancouver

Schmidt T , Paust H-J , Panzer U. Mechanisms and functions of IL-17 signaling in renal autoimmune diseases. MOL IMMUNOL. 2018 Dec;104:90-99. https://doi.org/10.1016/j.molimm.2018.09.005

Bibtex

@article{c4a4dbb78d484f82bddccb06135fa1ed,

title = "Mechanisms and functions of IL-17 signaling in renal autoimmune diseases",

abstract = "Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4+ T cell subset named TH17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Our group and others have shown that the recruitment of TH17 cells to the inflamed kidney drives renal tissue injury in experimental and possibly human crescentic glomerulonephritis (GN), but much remains to be understood about the biological functions, regulation, and signaling pathways of the TH17/IL-17 axis leading to organ damage. Here we review our current knowledge about the mechanisms and functions of IL-17 signaling in renal autoimmune diseases, with a special focus on experimental and human crescentic GN.",

keywords = "Journal Article, Glomerulonephritis/immunology, Autoimmune Diseases/immunology, Animals, Humans, Th17 Cells/immunology, Kidney/immunology, Interleukin-17, Organ Specificity/immunology",

author = "Tilman Schmidt and Hans-Joachim Paust and Ulf Panzer",

year = "2018",

month = dec,

doi = "10.1016/j.molimm.2018.09.005",

language = "English",

volume = "104",

pages = "90--99",

journal = "MOL IMMUNOL",

issn = "0161-5890",

publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Mechanisms and functions of IL-17 signaling in renal autoimmune diseases

AU - Schmidt, Tilman

AU - Paust, Hans-Joachim

AU - Panzer, Ulf

PY - 2018/12

Y1 - 2018/12

N2 - Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4+ T cell subset named TH17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Our group and others have shown that the recruitment of TH17 cells to the inflamed kidney drives renal tissue injury in experimental and possibly human crescentic glomerulonephritis (GN), but much remains to be understood about the biological functions, regulation, and signaling pathways of the TH17/IL-17 axis leading to organ damage. Here we review our current knowledge about the mechanisms and functions of IL-17 signaling in renal autoimmune diseases, with a special focus on experimental and human crescentic GN.

AB - Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4+ T cell subset named TH17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Our group and others have shown that the recruitment of TH17 cells to the inflamed kidney drives renal tissue injury in experimental and possibly human crescentic glomerulonephritis (GN), but much remains to be understood about the biological functions, regulation, and signaling pathways of the TH17/IL-17 axis leading to organ damage. Here we review our current knowledge about the mechanisms and functions of IL-17 signaling in renal autoimmune diseases, with a special focus on experimental and human crescentic GN.

KW - Journal Article

KW - Glomerulonephritis/immunology

KW - Autoimmune Diseases/immunology

KW - Animals

KW - Humans

KW - Th17 Cells/immunology

KW - Kidney/immunology

KW - Interleukin-17

KW - Organ Specificity/immunology

U2 - 10.1016/j.molimm.2018.09.005

DO - 10.1016/j.molimm.2018.09.005

M3 - SCORING: Review article

C2 - 30448610

VL - 104

SP - 90

EP - 99

JO - MOL IMMUNOL

JF - MOL IMMUNOL

SN - 0161-5890

ER -