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MCS-18, a novel natural plant product prevents autoimmune diabetes.

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MCS-18, a novel natural plant product prevents autoimmune diabetes. / Seifarth, Christian; Littmann, Leonie; Resheq, Yazid; Rössner, Susanne; Goldwich, Andreas; Pangratz, Nadine; Kerek, Franz; Steinkasserer, Alexander; Zinser, Elisabeth.

In: IMMUNOL LETT, Vol. 139, No. 1-2, 1-2, 2011, p. 58-67.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Seifarth, C, Littmann, L, Resheq, Y, Rössner, S, Goldwich, A, Pangratz, N, Kerek, F, Steinkasserer, A & Zinser, E 2011, 'MCS-18, a novel natural plant product prevents autoimmune diabetes.', IMMUNOL LETT, vol. 139, no. 1-2, 1-2, pp. 58-67. <http://www.ncbi.nlm.nih.gov/pubmed/21600928?dopt=Citation>

APA

Seifarth, C., Littmann, L., Resheq, Y., Rössner, S., Goldwich, A., Pangratz, N., Kerek, F., Steinkasserer, A., & Zinser, E. (2011). MCS-18, a novel natural plant product prevents autoimmune diabetes. IMMUNOL LETT, 139(1-2), 58-67. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/21600928?dopt=Citation

Vancouver

Seifarth C, Littmann L, Resheq Y, Rössner S, Goldwich A, Pangratz N et al. MCS-18, a novel natural plant product prevents autoimmune diabetes. IMMUNOL LETT. 2011;139(1-2):58-67. 1-2.

Bibtex

@article{8979439ad6b04c56a874e28da073f883,
title = "MCS-18, a novel natural plant product prevents autoimmune diabetes.",
abstract = "There is still a vital need for new therapies in order to prevent or treat type I diabetes. In this respect, we report that MCS-18 a novel natural product isolated from the plant Helleborus purpurascens (i.e. Christmas rose) is able to increase diabetes free survival using the NOD-mouse model, which is accompanied with a diminished IFN-? secretion of splenocytes. In the animal group which has been treated with MCS-18 during week 8 and week 12 of age 70% of the animals showed a diabetes free survival at week 30, whereas in contrast in the untreated animals less than 10% were free of diabetes. MCS-18 treatment significantly reduced islet T-cell infiltrates as well as the rate of T-cell proliferation. Periinsular infiltrates in the MCS-18 treated animals showed a significantly enhanced number of Foxp3(+) CD25(+) T cells, indicating the increased presence of regulatory T cells. These studies show that MCS-18 exerts an efficient immunosuppressive activity with remarkable potential for the therapy of diseases characterized by pathological over-activation of the immune system.",
keywords = "Animals, Disease Progression, Disease Models, Animal, Mice, Kaplan-Meier Estimate, Gene Expression Regulation/drug effects, Immunosuppressive Agents/*therapeutic use, Lymphocyte Activation/immunology, T-Lymphocytes/immunology, Mice, Inbred NOD, Biological Agents/*therapeutic use, Dendritic Cells/drug effects/immunology/metabolism, Diabetes Mellitus, Type 1/genetics/immunology/*prevention & control, Forkhead Transcription Factors/genetics, Insulin/secretion, Interferon-gamma/secretion, Islets of Langerhans/drug effects/immunology/metabolism/pathology, RNA, Messenger/genetics, Spleen/immunology/metabolism, T-Lymphocytes, Regulatory/immunology/metabolism, Animals, Disease Progression, Disease Models, Animal, Mice, Kaplan-Meier Estimate, Gene Expression Regulation/drug effects, Immunosuppressive Agents/*therapeutic use, Lymphocyte Activation/immunology, T-Lymphocytes/immunology, Mice, Inbred NOD, Biological Agents/*therapeutic use, Dendritic Cells/drug effects/immunology/metabolism, Diabetes Mellitus, Type 1/genetics/immunology/*prevention & control, Forkhead Transcription Factors/genetics, Insulin/secretion, Interferon-gamma/secretion, Islets of Langerhans/drug effects/immunology/metabolism/pathology, RNA, Messenger/genetics, Spleen/immunology/metabolism, T-Lymphocytes, Regulatory/immunology/metabolism",
author = "Christian Seifarth and Leonie Littmann and Yazid Resheq and Susanne R{\"o}ssner and Andreas Goldwich and Nadine Pangratz and Franz Kerek and Alexander Steinkasserer and Elisabeth Zinser",
year = "2011",
language = "English",
volume = "139",
pages = "58--67",
journal = "IMMUNOL LETT",
issn = "0165-2478",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - MCS-18, a novel natural plant product prevents autoimmune diabetes.

AU - Seifarth, Christian

AU - Littmann, Leonie

AU - Resheq, Yazid

AU - Rössner, Susanne

AU - Goldwich, Andreas

AU - Pangratz, Nadine

AU - Kerek, Franz

AU - Steinkasserer, Alexander

AU - Zinser, Elisabeth

PY - 2011

Y1 - 2011

N2 - There is still a vital need for new therapies in order to prevent or treat type I diabetes. In this respect, we report that MCS-18 a novel natural product isolated from the plant Helleborus purpurascens (i.e. Christmas rose) is able to increase diabetes free survival using the NOD-mouse model, which is accompanied with a diminished IFN-? secretion of splenocytes. In the animal group which has been treated with MCS-18 during week 8 and week 12 of age 70% of the animals showed a diabetes free survival at week 30, whereas in contrast in the untreated animals less than 10% were free of diabetes. MCS-18 treatment significantly reduced islet T-cell infiltrates as well as the rate of T-cell proliferation. Periinsular infiltrates in the MCS-18 treated animals showed a significantly enhanced number of Foxp3(+) CD25(+) T cells, indicating the increased presence of regulatory T cells. These studies show that MCS-18 exerts an efficient immunosuppressive activity with remarkable potential for the therapy of diseases characterized by pathological over-activation of the immune system.

AB - There is still a vital need for new therapies in order to prevent or treat type I diabetes. In this respect, we report that MCS-18 a novel natural product isolated from the plant Helleborus purpurascens (i.e. Christmas rose) is able to increase diabetes free survival using the NOD-mouse model, which is accompanied with a diminished IFN-? secretion of splenocytes. In the animal group which has been treated with MCS-18 during week 8 and week 12 of age 70% of the animals showed a diabetes free survival at week 30, whereas in contrast in the untreated animals less than 10% were free of diabetes. MCS-18 treatment significantly reduced islet T-cell infiltrates as well as the rate of T-cell proliferation. Periinsular infiltrates in the MCS-18 treated animals showed a significantly enhanced number of Foxp3(+) CD25(+) T cells, indicating the increased presence of regulatory T cells. These studies show that MCS-18 exerts an efficient immunosuppressive activity with remarkable potential for the therapy of diseases characterized by pathological over-activation of the immune system.

KW - Animals

KW - Disease Progression

KW - Disease Models, Animal

KW - Mice

KW - Kaplan-Meier Estimate

KW - Gene Expression Regulation/drug effects

KW - Immunosuppressive Agents/therapeutic use

KW - Lymphocyte Activation/immunology

KW - T-Lymphocytes/immunology

KW - Mice, Inbred NOD

KW - Biological Agents/therapeutic use

KW - Dendritic Cells/drug effects/immunology/metabolism

KW - Diabetes Mellitus, Type 1/genetics/immunology/prevention & control

KW - Forkhead Transcription Factors/genetics

KW - Insulin/secretion

KW - Interferon-gamma/secretion

KW - Islets of Langerhans/drug effects/immunology/metabolism/pathology

KW - RNA, Messenger/genetics

KW - Spleen/immunology/metabolism

KW - T-Lymphocytes, Regulatory/immunology/metabolism

KW - Animals

KW - Disease Progression

KW - Disease Models, Animal

KW - Mice

KW - Kaplan-Meier Estimate

KW - Gene Expression Regulation/drug effects

KW - Immunosuppressive Agents/therapeutic use

KW - Lymphocyte Activation/immunology

KW - T-Lymphocytes/immunology

KW - Mice, Inbred NOD

KW - Biological Agents/therapeutic use

KW - Dendritic Cells/drug effects/immunology/metabolism

KW - Diabetes Mellitus, Type 1/genetics/immunology/prevention & control

KW - Forkhead Transcription Factors/genetics

KW - Insulin/secretion

KW - Interferon-gamma/secretion

KW - Islets of Langerhans/drug effects/immunology/metabolism/pathology

KW - RNA, Messenger/genetics

KW - Spleen/immunology/metabolism

KW - T-Lymphocytes, Regulatory/immunology/metabolism

M3 - SCORING: Journal article

VL - 139

SP - 58

EP - 67

JO - IMMUNOL LETT

JF - IMMUNOL LETT

SN - 0165-2478

IS - 1-2

M1 - 1-2

ER -