Mathematical studies of the dynamics of finite-size binary neural networks: A review of recent progress

TY - JOUR

T1 - Mathematical studies of the dynamics of finite-size binary neural networks: A review of recent progress

AU - Fasoli, Diego

AU - Panzeri, Stefano

PY - 2019/9/4

Y1 - 2019/9/4

N2 - Several mathematical approaches to studying analytically the dynamics of neural networks rely on mean-field approximations, which are rigorously applicable only to networks of infinite size. However, all existing real biological networks have finite size, and many of them, such as microscopic circuits in invertebrates, are composed only of a few tens of neurons. Thus, it is important to be able to extend to small-size networks our ability to study analytically neural dynamics. Analytical solutions of the dynamics of small-size neural networks have remained elusive for many decades, because the powerful methods of statistical analysis, such as the central limit theorem and the law of large numbers, do not apply to small networks. In this article, we critically review recent progress on the study of the dynamics of small networks composed of binary neurons. In particular, we review the mathematical techniques we developed for studying the bifurcations of the network dynamics, the dualism between neural activity and membrane potentials, cross-neuron correlations, and pattern storage in stochastic networks. Then, we compare our results with existing mathematical techniques for studying networks composed of a finite number of neurons. Finally, we highlight key challenges that remain open, future directions for further progress, and possible implications of our results for neuroscience.

AB - Several mathematical approaches to studying analytically the dynamics of neural networks rely on mean-field approximations, which are rigorously applicable only to networks of infinite size. However, all existing real biological networks have finite size, and many of them, such as microscopic circuits in invertebrates, are composed only of a few tens of neurons. Thus, it is important to be able to extend to small-size networks our ability to study analytically neural dynamics. Analytical solutions of the dynamics of small-size neural networks have remained elusive for many decades, because the powerful methods of statistical analysis, such as the central limit theorem and the law of large numbers, do not apply to small networks. In this article, we critically review recent progress on the study of the dynamics of small networks composed of binary neurons. In particular, we review the mathematical techniques we developed for studying the bifurcations of the network dynamics, the dualism between neural activity and membrane potentials, cross-neuron correlations, and pattern storage in stochastic networks. Then, we compare our results with existing mathematical techniques for studying networks composed of a finite number of neurons. Finally, we highlight key challenges that remain open, future directions for further progress, and possible implications of our results for neuroscience.

KW - Action Potentials

KW - Algorithms

KW - Animals

KW - Brain/physiology

KW - Computational Biology

KW - Humans

KW - Models, Neurological

KW - Models, Statistical

KW - Nerve Net

KW - Neurons/physiology

KW - Neurosciences/trends

KW - Probability

U2 - 10.3934/mbe.2019404

DO - 10.3934/mbe.2019404

M3 - SCORING: Review article

C2 - 31698653

VL - 16

SP - 8025

EP - 8059

JO - MATH BIOSCI ENG

JF - MATH BIOSCI ENG

SN - 1547-1063

IS - 6

ER -