INTRODUCTION: Episodic memory deficits consistently correlate with the presence of negative symptoms in schizophrenia, suggesting overlap between the underlying neural systems. Functional neuroimaging and lesion studies suggest that prefrontal hypoactivity may underlie both. The purpose of the present study was to further characterise this association in terms of functional lateralisation. A more pronounced association between psychomotor poverty and verbal memory deficits would suggest more left prefrontal overlap than right, and vice-versa for a more pronounced association with nonverbal memory deficits. METHODS: A total of 68 inpatients (48 males, 20 females) diagnosed with schizophrenia or schizoaffective disorder participated in this study. We evaluated the correlation between verbal and nonverbal memory performance (assessed using the RAVLT and BVMT, respectively) and psychomotor poverty (assessed using the SSPI). RESULTS: A trend towards a more pronounced association for nonverbal compared to verbal material was not upheld by conservative statistical testing. CONCLUSIONS: Bilateral prefrontal overlap between psychomotor poverty and episodic memory is the most conservative interpretation of these data.
