Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.

Chris Oschatz; Coen Maas; Bernd Lecher; Thomas Jansen; Jenny Björkqvist; Thomas Tradler; Reinhard Sedlmeier; Peter Burfeind; Sven Cichon; Sven Hammerschmidt; Werner Müller-Esterl; Walter A Wuillemin; Gunnar Nilsson; Thomas Renné

Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.

Standard

Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. / Oschatz, Chris; Maas, Coen; Lecher, Bernd; Jansen, Thomas; Björkqvist, Jenny; Tradler, Thomas; Sedlmeier, Reinhard; Burfeind, Peter; Cichon, Sven; Hammerschmidt, Sven; Müller-Esterl, Werner; Wuillemin, Walter A; Nilsson, Gunnar; Renné, Thomas.

In: IMMUNITY, Vol. 34, No. 2, 2, 2011, p. 258-268.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Oschatz, C, Maas, C, Lecher, B, Jansen, T, Björkqvist, J, Tradler, T, Sedlmeier, R, Burfeind, P, Cichon, S, Hammerschmidt, S, Müller-Esterl, W, Wuillemin, WA, Nilsson, G & Renné, T 2011, 'Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.', IMMUNITY, vol. 34, no. 2, 2, pp. 258-268. <http://www.ncbi.nlm.nih.gov/pubmed/21349432?dopt=Citation>

APA

Oschatz, C., Maas, C., Lecher, B., Jansen, T., Björkqvist, J., Tradler, T., Sedlmeier, R., Burfeind, P., Cichon, S., Hammerschmidt, S., Müller-Esterl, W., Wuillemin, W. A., Nilsson, G., & Renné, T. (2011). Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. IMMUNITY, 34(2), 258-268. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21349432?dopt=Citation

Vancouver

Oschatz C, Maas C, Lecher B, Jansen T, Björkqvist J, Tradler T et al. Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. IMMUNITY. 2011;34(2):258-268. 2.

Bibtex

@article{915d53e6fbdb42d8bba81cc756ca1f7f,

title = "Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.",

abstract = "Activated mast cells trigger edema in allergic and inflammatory disease. We report a paracrine mechanism by which mast cell-released heparin increases vascular permeability in vivo. Heparin activated the protease factor XII, which initiates bradykinin formation in plasma. Targeting factor XII or kinin B2 receptors abolished heparin-triggered leukocyte-endothelium adhesion and interfered with a mast cell-driven drop in blood pressure in rodents. Intravital laser scanning microscopy and tracer measurements showed heparin-driven fluid extravasation in mouse skin microvessels. Ablation of factor XII or kinin B2 receptors abolished heparin-induced skin edema and protected mice from allergen-activated mast cell-driven leakage. In contrast, heparin and activated mast cells induced excessive edema in mice deficient in the major inhibitor of factor XII, C1 esterase inhibitor. Allergen exposure triggered edema attacks in hereditary angioedema patients, lacking C1 esterase inhibitor. The data indicate that heparin-initiated bradykinin formation plays a fundamental role in mast cell-mediated diseases.",

keywords = "Animals, Male, Mice, Rats, Enzyme Activation, Cell Adhesion, Endothelial Cells/pathology, Paracrine Communication/physiology, Signal Transduction/physiology, Immunoglobulin E/immunology, Leukocytes/physiology, Bradykinin/*biosynthesis/genetics, Capillary Leak Syndrome/etiology/*physiopathology, Capillary Permeability/*physiology, Complement C1 Inhibitor Protein/physiology, Edema/etiology/physiopathology, Factor XII/physiology, Heparin/*physiology/secretion, Hypotension/etiology/physiopathology, Kallikrein-Kinin System/physiology, Mast Cells/*secretion, Passive Cutaneous Anaphylaxis/*physiology, Plasma, Skin/blood supply, Animals, Male, Mice, Rats, Enzyme Activation, Cell Adhesion, Endothelial Cells/pathology, Paracrine Communication/physiology, Signal Transduction/physiology, Immunoglobulin E/immunology, Leukocytes/physiology, Bradykinin/*biosynthesis/genetics, Capillary Leak Syndrome/etiology/*physiopathology, Capillary Permeability/*physiology, Complement C1 Inhibitor Protein/physiology, Edema/etiology/physiopathology, Factor XII/physiology, Heparin/*physiology/secretion, Hypotension/etiology/physiopathology, Kallikrein-Kinin System/physiology, Mast Cells/*secretion, Passive Cutaneous Anaphylaxis/*physiology, Plasma, Skin/blood supply",

author = "Chris Oschatz and Coen Maas and Bernd Lecher and Thomas Jansen and Jenny Bj{\"o}rkqvist and Thomas Tradler and Reinhard Sedlmeier and Peter Burfeind and Sven Cichon and Sven Hammerschmidt and Werner M{\"u}ller-Esterl and Wuillemin, {Walter A} and Gunnar Nilsson and Thomas Renn{\'e}",

year = "2011",

language = "English",

volume = "34",

pages = "258--268",

journal = "IMMUNITY",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

}

RIS

TY - JOUR

T1 - Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.

AU - Oschatz, Chris

AU - Maas, Coen

AU - Lecher, Bernd

AU - Jansen, Thomas

AU - Björkqvist, Jenny

AU - Tradler, Thomas

AU - Sedlmeier, Reinhard

AU - Burfeind, Peter

AU - Cichon, Sven

AU - Hammerschmidt, Sven

AU - Müller-Esterl, Werner

AU - Wuillemin, Walter A

AU - Nilsson, Gunnar

AU - Renné, Thomas

PY - 2011

Y1 - 2011

N2 - Activated mast cells trigger edema in allergic and inflammatory disease. We report a paracrine mechanism by which mast cell-released heparin increases vascular permeability in vivo. Heparin activated the protease factor XII, which initiates bradykinin formation in plasma. Targeting factor XII or kinin B2 receptors abolished heparin-triggered leukocyte-endothelium adhesion and interfered with a mast cell-driven drop in blood pressure in rodents. Intravital laser scanning microscopy and tracer measurements showed heparin-driven fluid extravasation in mouse skin microvessels. Ablation of factor XII or kinin B2 receptors abolished heparin-induced skin edema and protected mice from allergen-activated mast cell-driven leakage. In contrast, heparin and activated mast cells induced excessive edema in mice deficient in the major inhibitor of factor XII, C1 esterase inhibitor. Allergen exposure triggered edema attacks in hereditary angioedema patients, lacking C1 esterase inhibitor. The data indicate that heparin-initiated bradykinin formation plays a fundamental role in mast cell-mediated diseases.

AB - Activated mast cells trigger edema in allergic and inflammatory disease. We report a paracrine mechanism by which mast cell-released heparin increases vascular permeability in vivo. Heparin activated the protease factor XII, which initiates bradykinin formation in plasma. Targeting factor XII or kinin B2 receptors abolished heparin-triggered leukocyte-endothelium adhesion and interfered with a mast cell-driven drop in blood pressure in rodents. Intravital laser scanning microscopy and tracer measurements showed heparin-driven fluid extravasation in mouse skin microvessels. Ablation of factor XII or kinin B2 receptors abolished heparin-induced skin edema and protected mice from allergen-activated mast cell-driven leakage. In contrast, heparin and activated mast cells induced excessive edema in mice deficient in the major inhibitor of factor XII, C1 esterase inhibitor. Allergen exposure triggered edema attacks in hereditary angioedema patients, lacking C1 esterase inhibitor. The data indicate that heparin-initiated bradykinin formation plays a fundamental role in mast cell-mediated diseases.

KW - Animals

KW - Male

KW - Mice

KW - Rats

KW - Enzyme Activation

KW - Cell Adhesion

KW - Endothelial Cells/pathology

KW - Paracrine Communication/physiology

KW - Signal Transduction/physiology

KW - Immunoglobulin E/immunology

KW - Leukocytes/physiology

KW - Bradykinin/biosynthesis/genetics

KW - Capillary Leak Syndrome/etiology/physiopathology

KW - Capillary Permeability/physiology

KW - Complement C1 Inhibitor Protein/physiology

KW - Edema/etiology/physiopathology

KW - Factor XII/physiology

KW - Heparin/physiology/secretion

KW - Hypotension/etiology/physiopathology

KW - Kallikrein-Kinin System/physiology

KW - Mast Cells/secretion

KW - Passive Cutaneous Anaphylaxis/physiology

KW - Plasma

KW - Skin/blood supply