Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes.
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Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes. / Buesche, G; Teoman, H; Wilczak, Waldemar; Ganser, A; Hecker, H; Wilkens, L; Göhring, G; Schlegelberger, B; Bock, O; Georgii, A; Kreipe, H.
In: LEUKEMIA, Vol. 22, No. 2, 2, 2008, p. 313-322.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes.
AU - Buesche, G
AU - Teoman, H
AU - Wilczak, Waldemar
AU - Ganser, A
AU - Hecker, H
AU - Wilkens, L
AU - Göhring, G
AU - Schlegelberger, B
AU - Bock, O
AU - Georgii, A
AU - Kreipe, H
PY - 2008
Y1 - 2008
N2 - Marrow fibrosis (MF) has rarely been studied in myelodysplastic syndromes (MDS). There are no data on occurrence and significance of MF in the context of the World Health Organization (WHO) classification of disease. In total, 349 bone marrow biopsies from 200 patients with primary MDS were examined for MF and its prognostic relevance. MF correlated with multilineage dysplasia, more severe thrombopenia, higher probability of a clonal karyotype abnormality, and higher percentages of blasts in the peripheral blood (P
AB - Marrow fibrosis (MF) has rarely been studied in myelodysplastic syndromes (MDS). There are no data on occurrence and significance of MF in the context of the World Health Organization (WHO) classification of disease. In total, 349 bone marrow biopsies from 200 patients with primary MDS were examined for MF and its prognostic relevance. MF correlated with multilineage dysplasia, more severe thrombopenia, higher probability of a clonal karyotype abnormality, and higher percentages of blasts in the peripheral blood (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 22
SP - 313
EP - 322
JO - LEUKEMIA
JF - LEUKEMIA
SN - 0887-6924
IS - 2
M1 - 2
ER -