Research ExplorerPublicationsMarginal Zone Formation Requires ACKR3 Expression on B Cells

Marginal Zone Formation Requires ACKR3 Expression on B Cells

Standard

Marginal Zone Formation Requires ACKR3 Expression on B Cells. / Radice, Egle; Ameti, Rafet; Melgrati, Serena; Foglierini, Mathilde; Antonello, Paola; Stahl, Rolf A K; Thelen, Sylvia; Jarrossay, David; Thelen, Marcus.

In: CELL REP, Vol. 32, No. 5, 04.08.2020, p. 107951.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Radice, E, Ameti, R, Melgrati, S, Foglierini, M, Antonello, P, Stahl, RAK, Thelen, S, Jarrossay, D & Thelen, M 2020, 'Marginal Zone Formation Requires ACKR3 Expression on B Cells', CELL REP, vol. 32, no. 5, pp. 107951. https://doi.org/10.1016/j.celrep.2020.107951

APA

Radice, E., Ameti, R., Melgrati, S., Foglierini, M., Antonello, P., Stahl, R. A. K., Thelen, S., Jarrossay, D., & Thelen, M. (2020). Marginal Zone Formation Requires ACKR3 Expression on B Cells. CELL REP, 32(5), 107951. https://doi.org/10.1016/j.celrep.2020.107951

Vancouver

Radice E, Ameti R, Melgrati S, Foglierini M, Antonello P, Stahl RAK et al. Marginal Zone Formation Requires ACKR3 Expression on B Cells. CELL REP. 2020 Aug 4;32(5):107951. https://doi.org/10.1016/j.celrep.2020.107951

Bibtex

@article{c906a26c7a08465d87cffdecae21f054,
title = "Marginal Zone Formation Requires ACKR3 Expression on B Cells",
abstract = "The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs). ACKR3 is required for development of a functional MZ and for positioning of MZBs. Deletion of ACKR3 on B cells distorts the MZ, and MZBs fail to deliver antigens to follicles, reducing humoral responses. Reconstitution of MZ-deficient CD19ko mice shows that ACKR3- MZBs can differentiate into ACKR3+ MZBs, but not vice versa. The lack of a MZ is rescued by adoptive transfer of ACKR3-sufficient, and less by ACKR3-deficient, follicular B cells (FoBs); hence, ACKR3 expression is crucial for establishment of the MZ. The inability of CD19ko mice to respond to T-independent antigen is rescued when ACKR3-proficient, but not ACKR3-deficient, FoBs are transferred. Accordingly, ACKR3-deficient FoBs are able to reconstitute the MZ if the niche is pre-established by ACKR3-proficient MZBs.",
author = "Egle Radice and Rafet Ameti and Serena Melgrati and Mathilde Foglierini and Paola Antonello and Stahl, {Rolf A K} and Sylvia Thelen and David Jarrossay and Marcus Thelen",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = aug,
day = "4",
doi = "10.1016/j.celrep.2020.107951",
language = "English",
volume = "32",
pages = "107951",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Marginal Zone Formation Requires ACKR3 Expression on B Cells

AU - Radice, Egle

AU - Ameti, Rafet

AU - Melgrati, Serena

AU - Foglierini, Mathilde

AU - Antonello, Paola

AU - Stahl, Rolf A K

AU - Thelen, Sylvia

AU - Jarrossay, David

AU - Thelen, Marcus

N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020/8/4

Y1 - 2020/8/4

N2 - The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs). ACKR3 is required for development of a functional MZ and for positioning of MZBs. Deletion of ACKR3 on B cells distorts the MZ, and MZBs fail to deliver antigens to follicles, reducing humoral responses. Reconstitution of MZ-deficient CD19ko mice shows that ACKR3- MZBs can differentiate into ACKR3+ MZBs, but not vice versa. The lack of a MZ is rescued by adoptive transfer of ACKR3-sufficient, and less by ACKR3-deficient, follicular B cells (FoBs); hence, ACKR3 expression is crucial for establishment of the MZ. The inability of CD19ko mice to respond to T-independent antigen is rescued when ACKR3-proficient, but not ACKR3-deficient, FoBs are transferred. Accordingly, ACKR3-deficient FoBs are able to reconstitute the MZ if the niche is pre-established by ACKR3-proficient MZBs.

AB - The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs). ACKR3 is required for development of a functional MZ and for positioning of MZBs. Deletion of ACKR3 on B cells distorts the MZ, and MZBs fail to deliver antigens to follicles, reducing humoral responses. Reconstitution of MZ-deficient CD19ko mice shows that ACKR3- MZBs can differentiate into ACKR3+ MZBs, but not vice versa. The lack of a MZ is rescued by adoptive transfer of ACKR3-sufficient, and less by ACKR3-deficient, follicular B cells (FoBs); hence, ACKR3 expression is crucial for establishment of the MZ. The inability of CD19ko mice to respond to T-independent antigen is rescued when ACKR3-proficient, but not ACKR3-deficient, FoBs are transferred. Accordingly, ACKR3-deficient FoBs are able to reconstitute the MZ if the niche is pre-established by ACKR3-proficient MZBs.

U2 - 10.1016/j.celrep.2020.107951

DO - 10.1016/j.celrep.2020.107951

M3 - SCORING: Journal article

C2 - 32755592

VL - 32

SP - 107951

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -