Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction
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Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction. / Petersen, Marvin; Chevalier, Céleste; Naegele, Felix L; Ingwersen, Thies; Omidvarnia, Amir; Hoffstaedter, Felix; Patil, Kaustubh; Eickhoff, Simon B; Schnabel, Renate B; Kirchhof, Paulus; Schlemm, Eckhard; Cheng, Bastian; Thomalla, Götz; Jensen, Märit.
In: ALZHEIMERS DEMENT, Vol. 20, No. 7, 07.2024, p. 4512-4526.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction
AU - Petersen, Marvin
AU - Chevalier, Céleste
AU - Naegele, Felix L
AU - Ingwersen, Thies
AU - Omidvarnia, Amir
AU - Hoffstaedter, Felix
AU - Patil, Kaustubh
AU - Eickhoff, Simon B
AU - Schnabel, Renate B
AU - Kirchhof, Paulus
AU - Schlemm, Eckhard
AU - Cheng, Bastian
AU - Thomalla, Götz
AU - Jensen, Märit
N1 - © 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/7
Y1 - 2024/7
N2 - INTRODUCTION: Atrial fibrillation (AF) is associated with an elevated risk of cognitive impairment and dementia. Understanding the cognitive sequelae and brain structural changes associated with AF is vital for addressing ensuing health care needs.METHODS AND RESULTS: We examined 1335 stroke-free individuals with AF and 2683 matched controls using neuropsychological assessments and multimodal neuroimaging. The analysis revealed that individuals with AF exhibited deficits in executive function, processing speed, and reasoning, accompanied by reduced cortical thickness, elevated extracellular free-water content, and widespread white matter abnormalities, indicative of small vessel pathology. Notably, brain structural differences statistically mediated the relationship between AF and cognitive performance.DISCUSSION: Integrating a comprehensive analysis approach with extensive clinical and magnetic resonance imaging data, our study highlights small vessel pathology as a possible unifying link among AF, cognitive decline, and abnormal brain structure. These insights can inform diagnostic approaches and motivate the ongoing implementation of effective therapeutic strategies. Highlights We investigated neuropsychological and multimodal neuroimaging data of 1335 individuals with atrial fibrillation (AF) and 2683 matched controls. Our analysis revealed AF-associated deficits in cognitive domains of attention, executive function, processing speed, and reasoning. Cognitive deficits in the AF group were accompanied by structural brain alterations including reduced cortical thickness and gray matter volume, alongside increased extracellular free-water content as well as widespread differences of white matter integrity. Structural brain changes statistically mediated the link between AF and cognitive performance, emphasizing the potential of structural imaging markers as a diagnostic tool in AF-related cognitive decline.
AB - INTRODUCTION: Atrial fibrillation (AF) is associated with an elevated risk of cognitive impairment and dementia. Understanding the cognitive sequelae and brain structural changes associated with AF is vital for addressing ensuing health care needs.METHODS AND RESULTS: We examined 1335 stroke-free individuals with AF and 2683 matched controls using neuropsychological assessments and multimodal neuroimaging. The analysis revealed that individuals with AF exhibited deficits in executive function, processing speed, and reasoning, accompanied by reduced cortical thickness, elevated extracellular free-water content, and widespread white matter abnormalities, indicative of small vessel pathology. Notably, brain structural differences statistically mediated the relationship between AF and cognitive performance.DISCUSSION: Integrating a comprehensive analysis approach with extensive clinical and magnetic resonance imaging data, our study highlights small vessel pathology as a possible unifying link among AF, cognitive decline, and abnormal brain structure. These insights can inform diagnostic approaches and motivate the ongoing implementation of effective therapeutic strategies. Highlights We investigated neuropsychological and multimodal neuroimaging data of 1335 individuals with atrial fibrillation (AF) and 2683 matched controls. Our analysis revealed AF-associated deficits in cognitive domains of attention, executive function, processing speed, and reasoning. Cognitive deficits in the AF group were accompanied by structural brain alterations including reduced cortical thickness and gray matter volume, alongside increased extracellular free-water content as well as widespread differences of white matter integrity. Structural brain changes statistically mediated the link between AF and cognitive performance, emphasizing the potential of structural imaging markers as a diagnostic tool in AF-related cognitive decline.
U2 - 10.1002/alz.13870
DO - 10.1002/alz.13870
M3 - SCORING: Journal article
C2 - 38837525
VL - 20
SP - 4512
EP - 4526
JO - ALZHEIMERS DEMENT
JF - ALZHEIMERS DEMENT
SN - 1552-5260
IS - 7
ER -
