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Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.

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Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. / Sturm, Angelika; Amino, Rogerio; van de Sand, Claudia; Regen, Tommy; Retzlaff, Silke; Rennenberg, Annika; Krueger, Andreas; Pollok, Jörg-Matthias; Menard, Robert; Heussler, Volker T.

In: SCIENCE, Vol. 313, No. 5791, 5791, 2006, p. 1287-1290.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sturm, A, Amino, R, van de Sand, C, Regen, T, Retzlaff, S, Rennenberg, A, Krueger, A, Pollok, J-M, Menard, R & Heussler, VT 2006, 'Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.', SCIENCE, vol. 313, no. 5791, 5791, pp. 1287-1290. <http://www.ncbi.nlm.nih.gov/pubmed/16888102?dopt=Citation>

APA

Sturm, A., Amino, R., van de Sand, C., Regen, T., Retzlaff, S., Rennenberg, A., Krueger, A., Pollok, J-M., Menard, R., & Heussler, V. T. (2006). Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. SCIENCE, 313(5791), 1287-1290. [5791]. http://www.ncbi.nlm.nih.gov/pubmed/16888102?dopt=Citation

Vancouver

Sturm A, Amino R, van de Sand C, Regen T, Retzlaff S, Rennenberg A et al. Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. SCIENCE. 2006;313(5791):1287-1290. 5791.

Bibtex

@article{cac9c8d234934a1c8d85ca1c607018ca,
title = "Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.",
abstract = "The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as {"}eat me{"} signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.",
author = "Angelika Sturm and Rogerio Amino and {van de Sand}, Claudia and Tommy Regen and Silke Retzlaff and Annika Rennenberg and Andreas Krueger and J{\"o}rg-Matthias Pollok and Robert Menard and Heussler, {Volker T}",
year = "2006",
language = "Deutsch",
volume = "313",
pages = "1287--1290",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5791",

}

RIS

TY - JOUR

T1 - Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.

AU - Sturm, Angelika

AU - Amino, Rogerio

AU - van de Sand, Claudia

AU - Regen, Tommy

AU - Retzlaff, Silke

AU - Rennenberg, Annika

AU - Krueger, Andreas

AU - Pollok, Jörg-Matthias

AU - Menard, Robert

AU - Heussler, Volker T

PY - 2006

Y1 - 2006

N2 - The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.

AB - The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.

M3 - SCORING: Zeitschriftenaufsatz

VL - 313

SP - 1287

EP - 1290

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 5791

M1 - 5791

ER -