Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1

Juliane Mehlan; Frank Schüttauf; Johannes M Salamon; Uwe Kordes; Reinhard E Friedrich; Victor-Felix Mautner

doi:10.21873/anticanres.13181

Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1

Standard

Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1. / Mehlan, Juliane; Schüttauf, Frank ; Salamon, Johannes M ; Kordes, Uwe ; Friedrich, Reinhard E ; Mautner, Victor-Felix.

In: ANTICANCER RES, Vol. 39, No. 2, 02.2019, p. 827-831.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mehlan, J, Schüttauf, F , Salamon, JM , Kordes, U , Friedrich, RE & Mautner, V-F 2019, 'Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1', ANTICANCER RES, vol. 39, no. 2, pp. 827-831. https://doi.org/10.21873/anticanres.13181

APA

Mehlan, J., Schüttauf, F., Salamon, J. M., Kordes, U., Friedrich, R. E., & Mautner, V-F. (2019). Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1. ANTICANCER RES, 39(2), 827-831. https://doi.org/10.21873/anticanres.13181

Vancouver

Mehlan J, Schüttauf F , Salamon JM , Kordes U , Friedrich RE , Mautner V-F. Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1. ANTICANCER RES. 2019 Feb;39(2):827-831. https://doi.org/10.21873/anticanres.13181

Bibtex

@article{01abead852c341568ba7031497022837,

title = "Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1",

abstract = "This report describes the diagnosis and treatment of a 27-year-old patient with neurofibromatosis 1 (NF1) and late progression of a pre-existing optic pathway glioma (OPG) that caused significant reduction in vision. OPG is one of the diagnostic criteria for establishing the diagnosis of NF1. Most common findings of NF1 are caf{\'e}-au-lait spots, axillary and inguinal freckling of the skin, iris hamartoma (Lisch nodules), and tumors of the central nervous system and peripheral nerves. We successfully applied a modified International Society of Paediatric Oncology chemotherapy regimen for low-grade glioma in children with carboplatin dose adjustment according to the area under the plasma drug concentration-time curve calculation. During and after the chemotherapy, a clear improvement of the visual capacity was achieved. Age-adapted chemotherapy for symptomatic adult-onset OPG in patients with NF1 should be considered in individual cases.",

keywords = "Journal Article",

author = "Juliane Mehlan and Frank Sch{\"u}ttauf and Salamon, {Johannes M} and Uwe Kordes and Friedrich, {Reinhard E} and Victor-Felix Mautner",

year = "2019",

month = feb,

doi = "10.21873/anticanres.13181",

language = "English",

volume = "39",

pages = "827--831",

journal = "ANTICANCER RES",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "2",

}

RIS

TY - JOUR

T1 - Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1

AU - Mehlan, Juliane

AU - Schüttauf, Frank

AU - Salamon, Johannes M

AU - Kordes, Uwe

AU - Friedrich, Reinhard E

AU - Mautner, Victor-Felix

PY - 2019/2

Y1 - 2019/2

N2 - This report describes the diagnosis and treatment of a 27-year-old patient with neurofibromatosis 1 (NF1) and late progression of a pre-existing optic pathway glioma (OPG) that caused significant reduction in vision. OPG is one of the diagnostic criteria for establishing the diagnosis of NF1. Most common findings of NF1 are café-au-lait spots, axillary and inguinal freckling of the skin, iris hamartoma (Lisch nodules), and tumors of the central nervous system and peripheral nerves. We successfully applied a modified International Society of Paediatric Oncology chemotherapy regimen for low-grade glioma in children with carboplatin dose adjustment according to the area under the plasma drug concentration-time curve calculation. During and after the chemotherapy, a clear improvement of the visual capacity was achieved. Age-adapted chemotherapy for symptomatic adult-onset OPG in patients with NF1 should be considered in individual cases.

AB - This report describes the diagnosis and treatment of a 27-year-old patient with neurofibromatosis 1 (NF1) and late progression of a pre-existing optic pathway glioma (OPG) that caused significant reduction in vision. OPG is one of the diagnostic criteria for establishing the diagnosis of NF1. Most common findings of NF1 are café-au-lait spots, axillary and inguinal freckling of the skin, iris hamartoma (Lisch nodules), and tumors of the central nervous system and peripheral nerves. We successfully applied a modified International Society of Paediatric Oncology chemotherapy regimen for low-grade glioma in children with carboplatin dose adjustment according to the area under the plasma drug concentration-time curve calculation. During and after the chemotherapy, a clear improvement of the visual capacity was achieved. Age-adapted chemotherapy for symptomatic adult-onset OPG in patients with NF1 should be considered in individual cases.

KW - Journal Article

U2 - 10.21873/anticanres.13181

DO - 10.21873/anticanres.13181

M3 - SCORING: Journal article

C2 - 30711963

VL - 39

SP - 827

EP - 831

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 2

ER -