Research ExplorerPublicationsManaging neuropsychological impairment in multiple sclerosis...

Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS)

Standard

Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS). / Pöttgen, Jana; Friede, Tim; Lau, Stephanie; Gold, Stefan M; Letsch, Christa; Bender, Gabriele; Flachenecker, Peter; Heesen, Christoph; Penner, Iris-Katharina.

In: MULT SCLER RELAT DIS, Vol. 59, 103687, 03.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pöttgen, J, Friede, T, Lau, S, Gold, SM, Letsch, C, Bender, G, Flachenecker, P, Heesen, C & Penner, I-K 2022, 'Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS)', MULT SCLER RELAT DIS, vol. 59, 103687. https://doi.org/10.1016/j.msard.2022.103687

APA

Pöttgen, J., Friede, T., Lau, S., Gold, S. M., Letsch, C., Bender, G., Flachenecker, P., Heesen, C., & Penner, I-K. (2022). Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS). MULT SCLER RELAT DIS, 59, [103687]. https://doi.org/10.1016/j.msard.2022.103687

Vancouver

Pöttgen J, Friede T, Lau S, Gold SM, Letsch C, Bender G et al. Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS). MULT SCLER RELAT DIS. 2022 Mar;59. 103687. https://doi.org/10.1016/j.msard.2022.103687

Bibtex

@article{b39247977f3944eeb4c74d1758309ffb,
title = "Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS)",
abstract = "OBJECTIVE: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system of potential autoimmune origin that is frequently associated with neuropsychiatric symptoms and cognitive deficits, as well as with fatigue, stress and psychosocial burden. In the present controlled multi-centre trial we investigated whether two specific neuropsychological interventions (1. metacognitive training (MaTiMS); 2. computerized working memory training (BrainStim) in combination with MaTiMS) applied as add-on therapies to real life standard rehabilitation lead to increased benefit in self-perceived cognitive deficits (the primary outcome) in MS patients compared to standard rehab.METHODS: 288 adult persons in three German rehab centers with a confirmed diagnosis of MS were sequentially allocated to one of the three intervention groups. 249 (87%) participants completed the post assessment and 187 (63%) the online survey after 12 months. Perceived cognitive deficits, mood, fatigue, coping, and activity were evaluated by self-reports and neuropsychological tests at baseline and 4 weeks postintervention. All self-reports were additionally administered digitally at three, six, and twelve months from baseline.RESULTS: We could not show differential effects on the primary outcome between the intervention groups and the control group (p=.369, p=.934). Immediately after each intervention we could show beneficial time effects in all three groups on self-perceived cognitive deficits as well as on most of the other outcomes. The reported effects were however not sustained at 6 months follow-up.CONCLUSIONS: Our findings could not show an additional effect of specific cognitive training on cognitive deficit perception in MS. However, findings indicate that MS rehabilitation may improve patient reported outcomes in the short term. They also underline the need for concepts to maintain rehabilitation gains when patients return back home.",
author = "Jana P{\"o}ttgen and Tim Friede and Stephanie Lau and Gold, {Stefan M} and Christa Letsch and Gabriele Bender and Peter Flachenecker and Christoph Heesen and Iris-Katharina Penner",
note = "Copyright {\textcopyright} 2022. Published by Elsevier B.V.",
year = "2022",
month = mar,
doi = "10.1016/j.msard.2022.103687",
language = "English",
volume = "59",
journal = "MULT SCLER RELAT DIS",
issn = "2211-0348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Managing neuropsychological impairment in multiple sclerosis - Controlled study on a standardized metacognitive intervention (MaTiMS)

AU - Pöttgen, Jana

AU - Friede, Tim

AU - Lau, Stephanie

AU - Gold, Stefan M

AU - Letsch, Christa

AU - Bender, Gabriele

AU - Flachenecker, Peter

AU - Heesen, Christoph

AU - Penner, Iris-Katharina

N1 - Copyright © 2022. Published by Elsevier B.V.

PY - 2022/3

Y1 - 2022/3

N2 - OBJECTIVE: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system of potential autoimmune origin that is frequently associated with neuropsychiatric symptoms and cognitive deficits, as well as with fatigue, stress and psychosocial burden. In the present controlled multi-centre trial we investigated whether two specific neuropsychological interventions (1. metacognitive training (MaTiMS); 2. computerized working memory training (BrainStim) in combination with MaTiMS) applied as add-on therapies to real life standard rehabilitation lead to increased benefit in self-perceived cognitive deficits (the primary outcome) in MS patients compared to standard rehab.METHODS: 288 adult persons in three German rehab centers with a confirmed diagnosis of MS were sequentially allocated to one of the three intervention groups. 249 (87%) participants completed the post assessment and 187 (63%) the online survey after 12 months. Perceived cognitive deficits, mood, fatigue, coping, and activity were evaluated by self-reports and neuropsychological tests at baseline and 4 weeks postintervention. All self-reports were additionally administered digitally at three, six, and twelve months from baseline.RESULTS: We could not show differential effects on the primary outcome between the intervention groups and the control group (p=.369, p=.934). Immediately after each intervention we could show beneficial time effects in all three groups on self-perceived cognitive deficits as well as on most of the other outcomes. The reported effects were however not sustained at 6 months follow-up.CONCLUSIONS: Our findings could not show an additional effect of specific cognitive training on cognitive deficit perception in MS. However, findings indicate that MS rehabilitation may improve patient reported outcomes in the short term. They also underline the need for concepts to maintain rehabilitation gains when patients return back home.

AB - OBJECTIVE: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system of potential autoimmune origin that is frequently associated with neuropsychiatric symptoms and cognitive deficits, as well as with fatigue, stress and psychosocial burden. In the present controlled multi-centre trial we investigated whether two specific neuropsychological interventions (1. metacognitive training (MaTiMS); 2. computerized working memory training (BrainStim) in combination with MaTiMS) applied as add-on therapies to real life standard rehabilitation lead to increased benefit in self-perceived cognitive deficits (the primary outcome) in MS patients compared to standard rehab.METHODS: 288 adult persons in three German rehab centers with a confirmed diagnosis of MS were sequentially allocated to one of the three intervention groups. 249 (87%) participants completed the post assessment and 187 (63%) the online survey after 12 months. Perceived cognitive deficits, mood, fatigue, coping, and activity were evaluated by self-reports and neuropsychological tests at baseline and 4 weeks postintervention. All self-reports were additionally administered digitally at three, six, and twelve months from baseline.RESULTS: We could not show differential effects on the primary outcome between the intervention groups and the control group (p=.369, p=.934). Immediately after each intervention we could show beneficial time effects in all three groups on self-perceived cognitive deficits as well as on most of the other outcomes. The reported effects were however not sustained at 6 months follow-up.CONCLUSIONS: Our findings could not show an additional effect of specific cognitive training on cognitive deficit perception in MS. However, findings indicate that MS rehabilitation may improve patient reported outcomes in the short term. They also underline the need for concepts to maintain rehabilitation gains when patients return back home.

U2 - 10.1016/j.msard.2022.103687

DO - 10.1016/j.msard.2022.103687

M3 - SCORING: Journal article

C2 - 35189580

VL - 59

JO - MULT SCLER RELAT DIS

JF - MULT SCLER RELAT DIS

SN - 2211-0348

M1 - 103687

ER -