Research ExplorerPublicationsManagement of sinonasal undifferentiated carcinoma with intr...

Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature

Standard

Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. / Zielinski, Valerie; Laban, Simon; Tribius, Silke; Schafhausen, Philippe; Veldhoen, Simon; Knecht, Rainald; Clauditz, Till; Muenscher, Adrian.

In: ENT-EAR NOSE THROAT, Vol. 95, No. 1, 01.2016, p. 23-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zielinski, V, Laban, S, Tribius, S, Schafhausen, P, Veldhoen, S, Knecht, R, Clauditz, T & Muenscher, A 2016, 'Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature', ENT-EAR NOSE THROAT, vol. 95, no. 1, pp. 23-8.

APA

Zielinski, V., Laban, S., Tribius, S., Schafhausen, P., Veldhoen, S., Knecht, R., Clauditz, T., & Muenscher, A. (2016). Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ENT-EAR NOSE THROAT, 95(1), 23-8.

Vancouver

Zielinski V, Laban S, Tribius S, Schafhausen P, Veldhoen S, Knecht R et al. Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ENT-EAR NOSE THROAT. 2016 Jan;95(1):23-8.

Bibtex

@article{c84e091034d14e879a5826856963fa79,
title = "Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature",
abstract = "Sinonasal undifferentiated carcinoma (SNUC) represents less than 1% of all malignancies. Most of the tumors are diagnosed at an advanced stage, when they have already invaded neighboring tissue structures. We describe the cases of 2 patients with a substantial intracerebral extension of SNUC who were treated at our institution. One was treated with surgery followed by chemoradiotherapy. The other was primarily treated with induction chemotherapy with a combination of docetaxel, cisplatin, and 5-fluorouracil followed by concurrent chemo- and radiotherapy. In view of the rarity of SNUC, no prospective clinical trials have been performed and a gold standard for treatment has not yet been established. Therefore, treatment recommendations are based on level IV evidence. These recommendations are diverse and controversial. In our 2 cases, the patient who was treated with induction chemotherapy had a better outcome. In cases of intracerebral extension, radical surgery is necessary and induction chemotherapy should be considered.",
author = "Valerie Zielinski and Simon Laban and Silke Tribius and Philippe Schafhausen and Simon Veldhoen and Rainald Knecht and Till Clauditz and Adrian Muenscher",
year = "2016",
month = jan,
language = "English",
volume = "95",
pages = "23--8",
journal = "ENT-EAR NOSE THROAT",
issn = "0145-5613",
publisher = "Medquest Communications LLC",
number = "1",

}

RIS

TY - JOUR

T1 - Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature

AU - Zielinski, Valerie

AU - Laban, Simon

AU - Tribius, Silke

AU - Schafhausen, Philippe

AU - Veldhoen, Simon

AU - Knecht, Rainald

AU - Clauditz, Till

AU - Muenscher, Adrian

PY - 2016/1

Y1 - 2016/1

N2 - Sinonasal undifferentiated carcinoma (SNUC) represents less than 1% of all malignancies. Most of the tumors are diagnosed at an advanced stage, when they have already invaded neighboring tissue structures. We describe the cases of 2 patients with a substantial intracerebral extension of SNUC who were treated at our institution. One was treated with surgery followed by chemoradiotherapy. The other was primarily treated with induction chemotherapy with a combination of docetaxel, cisplatin, and 5-fluorouracil followed by concurrent chemo- and radiotherapy. In view of the rarity of SNUC, no prospective clinical trials have been performed and a gold standard for treatment has not yet been established. Therefore, treatment recommendations are based on level IV evidence. These recommendations are diverse and controversial. In our 2 cases, the patient who was treated with induction chemotherapy had a better outcome. In cases of intracerebral extension, radical surgery is necessary and induction chemotherapy should be considered.

AB - Sinonasal undifferentiated carcinoma (SNUC) represents less than 1% of all malignancies. Most of the tumors are diagnosed at an advanced stage, when they have already invaded neighboring tissue structures. We describe the cases of 2 patients with a substantial intracerebral extension of SNUC who were treated at our institution. One was treated with surgery followed by chemoradiotherapy. The other was primarily treated with induction chemotherapy with a combination of docetaxel, cisplatin, and 5-fluorouracil followed by concurrent chemo- and radiotherapy. In view of the rarity of SNUC, no prospective clinical trials have been performed and a gold standard for treatment has not yet been established. Therefore, treatment recommendations are based on level IV evidence. These recommendations are diverse and controversial. In our 2 cases, the patient who was treated with induction chemotherapy had a better outcome. In cases of intracerebral extension, radical surgery is necessary and induction chemotherapy should be considered.

M3 - SCORING: Journal article

C2 - 26829682

VL - 95

SP - 23

EP - 28

JO - ENT-EAR NOSE THROAT

JF - ENT-EAR NOSE THROAT

SN - 0145-5613

IS - 1

ER -