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Management of Germ Cell Tumours of the Testes in Adult Patients

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Management of Germ Cell Tumours of the Testes in Adult Patients : German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy. / Kliesch, Sabine; Schmidt, Stefanie; Wilborn, Doris; Aigner, Clemens; Albrecht, Walter; Bedke, Jens; Beintker, Matthias; Beyersdorff, Dirk; Bokemeyer, Carsten; Busch, Jonas; Classen, Johannes; de Wit, Maike; Dieckmann, Klaus-Peter; Diemer, Thorsten; Dieing, Anette; Gockel, Matthias; Göckel-Beining, Bernt; Hakenberg, Oliver W; Heidenreich, Axel; Heinzelbecker, Julia; Herkommer, Kathleen; Hermanns, Thomas; Kaufmann, Sascha; Kornmann, Marko; Kotzerke, Jörg; Krege, Susanne; Kristiansen, Glen; Lorch, Anja; Müller, Arndt-Christian; Oechsle, Karin; Ohloff, Timur; Oing, Christoph; Otto, Ulrich; Pfister, David; Pichler, Renate; Recken, Heinrich; Rick, Oliver; Rudolph, Yvonne; Ruf, Christian; Schirren, Joachim; Schmelz, Hans; Schmidberger, Heinz; Schrader, Mark; Schweyer, Stefan; Seeling, Stefanie; Souchon, Rainer; Winter, Christian; Wittekind, Christian; Zengerling, Friedemann; Zermann, D H; Zillmann, Roger; Albers, Peter.

In: UROL INT, Vol. 105, No. 3-4, 22.01.2021, p. 181-191.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Kliesch, S, Schmidt, S, Wilborn, D, Aigner, C, Albrecht, W, Bedke, J, Beintker, M, Beyersdorff, D, Bokemeyer, C, Busch, J, Classen, J, de Wit, M, Dieckmann, K-P, Diemer, T, Dieing, A, Gockel, M, Göckel-Beining, B, Hakenberg, OW, Heidenreich, A, Heinzelbecker, J, Herkommer, K, Hermanns, T, Kaufmann, S, Kornmann, M, Kotzerke, J, Krege, S, Kristiansen, G, Lorch, A, Müller, A-C, Oechsle, K, Ohloff, T, Oing, C, Otto, U, Pfister, D, Pichler, R, Recken, H, Rick, O, Rudolph, Y, Ruf, C, Schirren, J, Schmelz, H, Schmidberger, H, Schrader, M, Schweyer, S, Seeling, S, Souchon, R, Winter, C, Wittekind, C, Zengerling, F, Zermann, DH, Zillmann, R & Albers, P 2021, 'Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy', UROL INT, vol. 105, no. 3-4, pp. 181-191. https://doi.org/10.1159/000511245

APA

Kliesch, S., Schmidt, S., Wilborn, D., Aigner, C., Albrecht, W., Bedke, J., Beintker, M., Beyersdorff, D., Bokemeyer, C., Busch, J., Classen, J., de Wit, M., Dieckmann, K-P., Diemer, T., Dieing, A., Gockel, M., Göckel-Beining, B., Hakenberg, O. W., Heidenreich, A., ... Albers, P. (2021). Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy. UROL INT, 105(3-4), 181-191. https://doi.org/10.1159/000511245

Vancouver

Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J et al. Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy. UROL INT. 2021 Jan 22;105(3-4):181-191. https://doi.org/10.1159/000511245

Bibtex

@article{66293370c46e448fb207750fcadc74ca,
title = "Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy",
abstract = "OBJECTIVES: We developed the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up of germ cell tumours (GCT) of the testes in adult patients. We present the guideline content in 2 separate publications. The present second part summarizes therecommendations for the treatment of advanced disease stages and for the management of follow-up and late effects.MATERIALS AND METHODS: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search in March 2018), were provided. Thirty-one experts, who were entitled to vote, rated the final clinical recommendations and statements.RESULTS: Here we present the treatment recommendations separately for patients with metastatic seminoma and non-seminomatous GCT (stages IIA/B and IIC/III), for restaging and treatment of residual masses, and for relapsed and refractory disease stages. The recommendations also cover extragonadal and sex cord/stromal tumours, the management of follow-up and toxicity, quality-of-life aspects, palliative care, and supportive therapy.CONCLUSION: Physicians and other medical service providers who are involved in the diagnostics, treatment, and follow-up of GCT (all stages, outpatient and inpatient care as well as rehabilitation) are the users of the present guideline. The guideline also comprises quality indicators for measuring the implementation of the guideline recommendations in routine clinical care; these data will be presented in a future publication.",
author = "Sabine Kliesch and Stefanie Schmidt and Doris Wilborn and Clemens Aigner and Walter Albrecht and Jens Bedke and Matthias Beintker and Dirk Beyersdorff and Carsten Bokemeyer and Jonas Busch and Johannes Classen and {de Wit}, Maike and Klaus-Peter Dieckmann and Thorsten Diemer and Anette Dieing and Matthias Gockel and Bernt G{\"o}ckel-Beining and Hakenberg, {Oliver W} and Axel Heidenreich and Julia Heinzelbecker and Kathleen Herkommer and Thomas Hermanns and Sascha Kaufmann and Marko Kornmann and J{\"o}rg Kotzerke and Susanne Krege and Glen Kristiansen and Anja Lorch and Arndt-Christian M{\"u}ller and Karin Oechsle and Timur Ohloff and Christoph Oing and Ulrich Otto and David Pfister and Renate Pichler and Heinrich Recken and Oliver Rick and Yvonne Rudolph and Christian Ruf and Joachim Schirren and Hans Schmelz and Heinz Schmidberger and Mark Schrader and Stefan Schweyer and Stefanie Seeling and Rainer Souchon and Christian Winter and Christian Wittekind and Friedemann Zengerling and Zermann, {D H} and Roger Zillmann and Peter Albers",
note = "{\textcopyright} 2021 The Author(s) Published by S. Karger AG, Basel.",
year = "2021",
month = jan,
day = "22",
doi = "10.1159/000511245",
language = "English",
volume = "105",
pages = "181--191",
journal = "UROL INT",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "3-4",

}

RIS

TY - JOUR

T1 - Management of Germ Cell Tumours of the Testes in Adult Patients

T2 - German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy

AU - Kliesch, Sabine

AU - Schmidt, Stefanie

AU - Wilborn, Doris

AU - Aigner, Clemens

AU - Albrecht, Walter

AU - Bedke, Jens

AU - Beintker, Matthias

AU - Beyersdorff, Dirk

AU - Bokemeyer, Carsten

AU - Busch, Jonas

AU - Classen, Johannes

AU - de Wit, Maike

AU - Dieckmann, Klaus-Peter

AU - Diemer, Thorsten

AU - Dieing, Anette

AU - Gockel, Matthias

AU - Göckel-Beining, Bernt

AU - Hakenberg, Oliver W

AU - Heidenreich, Axel

AU - Heinzelbecker, Julia

AU - Herkommer, Kathleen

AU - Hermanns, Thomas

AU - Kaufmann, Sascha

AU - Kornmann, Marko

AU - Kotzerke, Jörg

AU - Krege, Susanne

AU - Kristiansen, Glen

AU - Lorch, Anja

AU - Müller, Arndt-Christian

AU - Oechsle, Karin

AU - Ohloff, Timur

AU - Oing, Christoph

AU - Otto, Ulrich

AU - Pfister, David

AU - Pichler, Renate

AU - Recken, Heinrich

AU - Rick, Oliver

AU - Rudolph, Yvonne

AU - Ruf, Christian

AU - Schirren, Joachim

AU - Schmelz, Hans

AU - Schmidberger, Heinz

AU - Schrader, Mark

AU - Schweyer, Stefan

AU - Seeling, Stefanie

AU - Souchon, Rainer

AU - Winter, Christian

AU - Wittekind, Christian

AU - Zengerling, Friedemann

AU - Zermann, D H

AU - Zillmann, Roger

AU - Albers, Peter

N1 - © 2021 The Author(s) Published by S. Karger AG, Basel.

PY - 2021/1/22

Y1 - 2021/1/22

N2 - OBJECTIVES: We developed the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up of germ cell tumours (GCT) of the testes in adult patients. We present the guideline content in 2 separate publications. The present second part summarizes therecommendations for the treatment of advanced disease stages and for the management of follow-up and late effects.MATERIALS AND METHODS: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search in March 2018), were provided. Thirty-one experts, who were entitled to vote, rated the final clinical recommendations and statements.RESULTS: Here we present the treatment recommendations separately for patients with metastatic seminoma and non-seminomatous GCT (stages IIA/B and IIC/III), for restaging and treatment of residual masses, and for relapsed and refractory disease stages. The recommendations also cover extragonadal and sex cord/stromal tumours, the management of follow-up and toxicity, quality-of-life aspects, palliative care, and supportive therapy.CONCLUSION: Physicians and other medical service providers who are involved in the diagnostics, treatment, and follow-up of GCT (all stages, outpatient and inpatient care as well as rehabilitation) are the users of the present guideline. The guideline also comprises quality indicators for measuring the implementation of the guideline recommendations in routine clinical care; these data will be presented in a future publication.

AB - OBJECTIVES: We developed the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up of germ cell tumours (GCT) of the testes in adult patients. We present the guideline content in 2 separate publications. The present second part summarizes therecommendations for the treatment of advanced disease stages and for the management of follow-up and late effects.MATERIALS AND METHODS: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search in March 2018), were provided. Thirty-one experts, who were entitled to vote, rated the final clinical recommendations and statements.RESULTS: Here we present the treatment recommendations separately for patients with metastatic seminoma and non-seminomatous GCT (stages IIA/B and IIC/III), for restaging and treatment of residual masses, and for relapsed and refractory disease stages. The recommendations also cover extragonadal and sex cord/stromal tumours, the management of follow-up and toxicity, quality-of-life aspects, palliative care, and supportive therapy.CONCLUSION: Physicians and other medical service providers who are involved in the diagnostics, treatment, and follow-up of GCT (all stages, outpatient and inpatient care as well as rehabilitation) are the users of the present guideline. The guideline also comprises quality indicators for measuring the implementation of the guideline recommendations in routine clinical care; these data will be presented in a future publication.

U2 - 10.1159/000511245

DO - 10.1159/000511245

M3 - SCORING: Review article

C2 - 33486494

VL - 105

SP - 181

EP - 191

JO - UROL INT

JF - UROL INT

SN - 0042-1138

IS - 3-4

ER -