Management of Cytokine Release Syndrome (CRS) and HLH

Abstract

Cytokine release syndrome (CRS) is caused by a rapid and mild to massive release of cytokines from immune cells involved in immune reactions, particularly after immunotherapy. The frequency and severity of CRS after CAR-T cell therapy varies between products (any grade: 37–93%, G3/4: 1–23%) (Neelapu et al. 2017; Schuster et al. 2019; Abramson et al. 2020).

Bibliographical data

Original languageEnglish
Title of host publicationThe EBMT/EHA CAR-T Cell Handbook
EditorsNicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele
REQUIRED books only: Number of pages5
Place of PublicationCham
PublisherSpringer International Publishing
Publication date2022
Edition1
Pages135-139
ISBN (Print)978-3-030-94352-3
ISBN (Electronic)978-3-030-94353-0
DOIs
Publication statusPublished - 2022