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Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach

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Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach. / Van Edom, Charlotte J; Gramegna, Mario; Baldetti, Luca; Beneduce, Alessandro; Castelein, Thomas; Dauwe, Dieter; Frederiks, Pascal; Giustino, Gennaro; Jacquemin, Marc; Janssens, Stefan P; Panoulas, Vasileios F; Pöss, Janine; Rosenberg, Alexander; Schaubroeck, Hannah A I; Schrage, Benedikt; Tavazzi, Guido; Vanassche, Thomas; Vercaemst, Leen; Vlasselaers, Dirk; Vranckx, Pascal; Belohlavek, Jan; Gorog, Diana A; Huber, Kurt; Mebazaa, Alexandre; Meyns, Bart; Pappalardo, Federico; Scandroglio, Anna M; Stone, Gregg W; Westermann, Dirk; Chieffo, Alaide; Price, Susanna; Vandenbriele, Christophe.

In: JACC-CARDIOVASC INTE, Vol. 16, No. 14, 24.07.2023, p. 1707-1720.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Van Edom, CJ, Gramegna, M, Baldetti, L, Beneduce, A, Castelein, T, Dauwe, D, Frederiks, P, Giustino, G, Jacquemin, M, Janssens, SP, Panoulas, VF, Pöss, J, Rosenberg, A, Schaubroeck, HAI, Schrage, B, Tavazzi, G, Vanassche, T, Vercaemst, L, Vlasselaers, D, Vranckx, P, Belohlavek, J, Gorog, DA, Huber, K, Mebazaa, A, Meyns, B, Pappalardo, F, Scandroglio, AM, Stone, GW, Westermann, D, Chieffo, A, Price, S & Vandenbriele, C 2023, 'Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach', JACC-CARDIOVASC INTE, vol. 16, no. 14, pp. 1707-1720. https://doi.org/10.1016/j.jcin.2023.05.043

APA

Van Edom, C. J., Gramegna, M., Baldetti, L., Beneduce, A., Castelein, T., Dauwe, D., Frederiks, P., Giustino, G., Jacquemin, M., Janssens, S. P., Panoulas, V. F., Pöss, J., Rosenberg, A., Schaubroeck, H. A. I., Schrage, B., Tavazzi, G., Vanassche, T., Vercaemst, L., Vlasselaers, D., ... Vandenbriele, C. (2023). Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach. JACC-CARDIOVASC INTE, 16(14), 1707-1720. https://doi.org/10.1016/j.jcin.2023.05.043

Vancouver

Van Edom CJ, Gramegna M, Baldetti L, Beneduce A, Castelein T, Dauwe D et al. Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach. JACC-CARDIOVASC INTE. 2023 Jul 24;16(14):1707-1720. https://doi.org/10.1016/j.jcin.2023.05.043

Bibtex

@article{cad05261b9c243e38c8c1a4faeef2ebd,
title = "Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach",
abstract = "Percutaneous ventricular assist devices (pVADs) are increasingly being used because of improved experience and availability. The Impella (Abiomed), a percutaneous microaxial, continuous-flow, short-term ventricular assist device, requires meticulous postimplantation management to avoid the 2 most frequent complications, namely, bleeding and hemolysis. A standardized approach to the prevention, detection, and treatment of these complications is mandatory to improve outcomes. The risk for hemolysis is mostly influenced by pump instability, resulting from patient- or device-related factors. Upfront echocardiographic assessment, frequent monitoring, and prompt intervention are essential. The precarious hemostatic balance during pVAD support results from the combination of a procoagulant state, due to critical illness and contact pathway activation, together with a variety of factors aggravating bleeding risk. Preventive strategies and appropriate management, adapted to the impact of the bleeding, are crucial. This review offers a guide to physicians to tackle these device-related complications in this critically ill pVAD-supported patient population.",
keywords = "Humans, Treatment Outcome, Hemolysis, Percutaneous Coronary Intervention/adverse effects, Heart-Assist Devices/adverse effects, Hemorrhage/diagnostic imaging, Shock, Cardiogenic",
author = "{Van Edom}, {Charlotte J} and Mario Gramegna and Luca Baldetti and Alessandro Beneduce and Thomas Castelein and Dieter Dauwe and Pascal Frederiks and Gennaro Giustino and Marc Jacquemin and Janssens, {Stefan P} and Panoulas, {Vasileios F} and Janine P{\"o}ss and Alexander Rosenberg and Schaubroeck, {Hannah A I} and Benedikt Schrage and Guido Tavazzi and Thomas Vanassche and Leen Vercaemst and Dirk Vlasselaers and Pascal Vranckx and Jan Belohlavek and Gorog, {Diana A} and Kurt Huber and Alexandre Mebazaa and Bart Meyns and Federico Pappalardo and Scandroglio, {Anna M} and Stone, {Gregg W} and Dirk Westermann and Alaide Chieffo and Susanna Price and Christophe Vandenbriele",
note = "Copyright {\textcopyright} 2023 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = jul,
day = "24",
doi = "10.1016/j.jcin.2023.05.043",
language = "English",
volume = "16",
pages = "1707--1720",
journal = "JACC-CARDIOVASC INTE",
issn = "1936-8798",
publisher = "Elsevier Inc.",
number = "14",

}

RIS

TY - JOUR

T1 - Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach

AU - Van Edom, Charlotte J

AU - Gramegna, Mario

AU - Baldetti, Luca

AU - Beneduce, Alessandro

AU - Castelein, Thomas

AU - Dauwe, Dieter

AU - Frederiks, Pascal

AU - Giustino, Gennaro

AU - Jacquemin, Marc

AU - Janssens, Stefan P

AU - Panoulas, Vasileios F

AU - Pöss, Janine

AU - Rosenberg, Alexander

AU - Schaubroeck, Hannah A I

AU - Schrage, Benedikt

AU - Tavazzi, Guido

AU - Vanassche, Thomas

AU - Vercaemst, Leen

AU - Vlasselaers, Dirk

AU - Vranckx, Pascal

AU - Belohlavek, Jan

AU - Gorog, Diana A

AU - Huber, Kurt

AU - Mebazaa, Alexandre

AU - Meyns, Bart

AU - Pappalardo, Federico

AU - Scandroglio, Anna M

AU - Stone, Gregg W

AU - Westermann, Dirk

AU - Chieffo, Alaide

AU - Price, Susanna

AU - Vandenbriele, Christophe

N1 - Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2023/7/24

Y1 - 2023/7/24

N2 - Percutaneous ventricular assist devices (pVADs) are increasingly being used because of improved experience and availability. The Impella (Abiomed), a percutaneous microaxial, continuous-flow, short-term ventricular assist device, requires meticulous postimplantation management to avoid the 2 most frequent complications, namely, bleeding and hemolysis. A standardized approach to the prevention, detection, and treatment of these complications is mandatory to improve outcomes. The risk for hemolysis is mostly influenced by pump instability, resulting from patient- or device-related factors. Upfront echocardiographic assessment, frequent monitoring, and prompt intervention are essential. The precarious hemostatic balance during pVAD support results from the combination of a procoagulant state, due to critical illness and contact pathway activation, together with a variety of factors aggravating bleeding risk. Preventive strategies and appropriate management, adapted to the impact of the bleeding, are crucial. This review offers a guide to physicians to tackle these device-related complications in this critically ill pVAD-supported patient population.

AB - Percutaneous ventricular assist devices (pVADs) are increasingly being used because of improved experience and availability. The Impella (Abiomed), a percutaneous microaxial, continuous-flow, short-term ventricular assist device, requires meticulous postimplantation management to avoid the 2 most frequent complications, namely, bleeding and hemolysis. A standardized approach to the prevention, detection, and treatment of these complications is mandatory to improve outcomes. The risk for hemolysis is mostly influenced by pump instability, resulting from patient- or device-related factors. Upfront echocardiographic assessment, frequent monitoring, and prompt intervention are essential. The precarious hemostatic balance during pVAD support results from the combination of a procoagulant state, due to critical illness and contact pathway activation, together with a variety of factors aggravating bleeding risk. Preventive strategies and appropriate management, adapted to the impact of the bleeding, are crucial. This review offers a guide to physicians to tackle these device-related complications in this critically ill pVAD-supported patient population.

KW - Humans

KW - Treatment Outcome

KW - Hemolysis

KW - Percutaneous Coronary Intervention/adverse effects

KW - Heart-Assist Devices/adverse effects

KW - Hemorrhage/diagnostic imaging

KW - Shock, Cardiogenic

U2 - 10.1016/j.jcin.2023.05.043

DO - 10.1016/j.jcin.2023.05.043

M3 - SCORING: Review article

C2 - 37495347

VL - 16

SP - 1707

EP - 1720

JO - JACC-CARDIOVASC INTE

JF - JACC-CARDIOVASC INTE

SN - 1936-8798

IS - 14

ER -