Malignant melanoma metastasis as a cause of small-bowel perforation
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Malignant melanoma metastasis as a cause of small-bowel perforation. / Tsilimparis, Nikolaos; Menenakos, Charalampos; Rogalla, Patrick; Braumann, Chris; Hartmann, Jens.
In: ONKOLOGIE, Vol. 32, No. 6, 06.2009, p. 356-358.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Malignant melanoma metastasis as a cause of small-bowel perforation
AU - Tsilimparis, Nikolaos
AU - Menenakos, Charalampos
AU - Rogalla, Patrick
AU - Braumann, Chris
AU - Hartmann, Jens
N1 - Copyright 2009 S. Karger AG, Basel.
PY - 2009/6
Y1 - 2009/6
N2 - BACKGROUND: Malignant melanoma is a disease with an increasing rate of incidence, currently at 10 cases per 100,000. In most cases, malignant melanoma metastasizes over the lymph vessels to parenchymal organs. Symptomatic metastases are found in the gastrointestinal tract in only about 2% of the patients.CASE REPORT: A 43-year-old patient with a known metastasized malignant melanoma (brain, liver, bones) was admitted to the department of dermatology due to fatigue, headache and unspecified abdominal symptoms. Because of persistent abdominal symptoms, a computed tomography (CT) scan of the abdomen was performed, showing a perforation of the ileum with an abscess on the basis of multiple small-bowel metastases. A segmental small-bowel resection with primary anastomosis was performed. The postoperative course of the patient was complicated by a subcutaneous wound infection and a prolonged period of convalescence (due to multiple brain metastases).CONCLUSIONS: Novel therapy concepts and medication in the treatment of patients with malignant melanoma have improved life expectancy. These patients are therefore expected to suffer more frequently from complications of the primary disease. Interdisciplinary management and cooperation is required to adequately diagnose and handle such cases.
AB - BACKGROUND: Malignant melanoma is a disease with an increasing rate of incidence, currently at 10 cases per 100,000. In most cases, malignant melanoma metastasizes over the lymph vessels to parenchymal organs. Symptomatic metastases are found in the gastrointestinal tract in only about 2% of the patients.CASE REPORT: A 43-year-old patient with a known metastasized malignant melanoma (brain, liver, bones) was admitted to the department of dermatology due to fatigue, headache and unspecified abdominal symptoms. Because of persistent abdominal symptoms, a computed tomography (CT) scan of the abdomen was performed, showing a perforation of the ileum with an abscess on the basis of multiple small-bowel metastases. A segmental small-bowel resection with primary anastomosis was performed. The postoperative course of the patient was complicated by a subcutaneous wound infection and a prolonged period of convalescence (due to multiple brain metastases).CONCLUSIONS: Novel therapy concepts and medication in the treatment of patients with malignant melanoma have improved life expectancy. These patients are therefore expected to suffer more frequently from complications of the primary disease. Interdisciplinary management and cooperation is required to adequately diagnose and handle such cases.
KW - Adult
KW - Humans
KW - Intestinal Neoplasms/complications
KW - Intestinal Perforation/diagnosis
KW - Intestine, Small/injuries
KW - Male
KW - Melanoma/diagnosis
KW - Skin Neoplasms/complications
U2 - 10.1159/000215718
DO - 10.1159/000215718
M3 - SCORING: Journal article
C2 - 19521125
VL - 32
SP - 356
EP - 358
JO - ONKOLOGIE
JF - ONKOLOGIE
SN - 0378-584X
IS - 6
ER -
