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Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies

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Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies. / Ramiro-Cortijo, David; de la Calle, María; Böger, Rainer; Hannemann, Juliane; Lüneburg, Nicole; López-Giménez, María Rosario; Rodríguez-Rodríguez, Pilar; Martín-Cabrejas, María Ángeles; Benítez, Vanesa; de Pablo, Ángel Luis López; González, María Del Carmen; Arribas, Silvia M.

In: CYTOKINE, Vol. 136, 12.2020, p. 155290.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ramiro-Cortijo, D, de la Calle, M, Böger, R, Hannemann, J, Lüneburg, N, López-Giménez, MR, Rodríguez-Rodríguez, P, Martín-Cabrejas, MÁ, Benítez, V, de Pablo, ÁLL, González, MDC & Arribas, SM 2020, 'Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies', CYTOKINE, vol. 136, pp. 155290. https://doi.org/10.1016/j.cyto.2020.155290

APA

Ramiro-Cortijo, D., de la Calle, M., Böger, R., Hannemann, J., Lüneburg, N., López-Giménez, M. R., Rodríguez-Rodríguez, P., Martín-Cabrejas, M. Á., Benítez, V., de Pablo, Á. L. L., González, M. D. C., & Arribas, S. M. (2020). Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies. CYTOKINE, 136, 155290. https://doi.org/10.1016/j.cyto.2020.155290

Vancouver

Ramiro-Cortijo D, de la Calle M, Böger R, Hannemann J, Lüneburg N, López-Giménez MR et al. Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies. CYTOKINE. 2020 Dec;136:155290. https://doi.org/10.1016/j.cyto.2020.155290

Bibtex

@article{50c5abc57c0549dd8e2a482b8d0e8075,
title = "Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies",
abstract = "Male fetal sex associates with higher rates of materno-fetal complications. Inflammation and inadequate vasoactive responses are mechanisms implicated in obstetric complications, and alterations in maternal plasma cytokine profile and nitric oxide (NO) metabolites are potential predictive biomarkers. We aimed to assess if these parameters are influenced by fetal sex. A prospective, observational study was carried out in 85 healthy pregnant women with singleton pregnancies in the first trimester of gestation. A blood sample was extracted at the tenth week of gestation. In plasma, we assessed: 1) cytokines (micro-array): pro-inflammatory (IL1α, IL1 β, IL6, TNFα), anti-inflammatory (IL4, IL10, IL13), and chemoattractant (IL8, MCP1, IFNγ), and 2) NO metabolites (liquid chromatography-tandem mass spectrometry and Griess reaction): L-arginine, ADMA, SDMA, nitrates (NOx). Women with a male fetus (n = 50) exhibited, compared with those with a female (n = 35): higher IL1β (OR = 1.09 with 95% CI: 0.97-1.28), and lower IL13 (OR = 0.93 with 95% CI: 0.87-0.99), and higher plasma NOx (OR = 1.14 with 95% CI: 1.03-1.31). Our data suggest that fetal sex influences maternal plasma cytokine profile and NO in early pregnancy. Women with a male fetus may have a worse capacity to counteract an inflammatory response. They may have better vasodilator capacity, but in the presence of an oxidative environment, a higher nitrosative damage may occur. These data reinforce the need to include sex as variable in predictive models.",
author = "David Ramiro-Cortijo and {de la Calle}, Mar{\'i}a and Rainer B{\"o}ger and Juliane Hannemann and Nicole L{\"u}neburg and L{\'o}pez-Gim{\'e}nez, {Mar{\'i}a Rosario} and Pilar Rodr{\'i}guez-Rodr{\'i}guez and Mart{\'i}n-Cabrejas, {Mar{\'i}a {\'A}ngeles} and Vanesa Ben{\'i}tez and {de Pablo}, {{\'A}ngel Luis L{\'o}pez} and Gonz{\'a}lez, {Mar{\'i}a Del Carmen} and Arribas, {Silvia M}",
note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",
year = "2020",
month = dec,
doi = "10.1016/j.cyto.2020.155290",
language = "English",
volume = "136",
pages = "155290",
journal = "CYTOKINE",
issn = "1043-4666",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies

AU - Ramiro-Cortijo, David

AU - de la Calle, María

AU - Böger, Rainer

AU - Hannemann, Juliane

AU - Lüneburg, Nicole

AU - López-Giménez, María Rosario

AU - Rodríguez-Rodríguez, Pilar

AU - Martín-Cabrejas, María Ángeles

AU - Benítez, Vanesa

AU - de Pablo, Ángel Luis López

AU - González, María Del Carmen

AU - Arribas, Silvia M

N1 - Copyright © 2020. Published by Elsevier Ltd.

PY - 2020/12

Y1 - 2020/12

N2 - Male fetal sex associates with higher rates of materno-fetal complications. Inflammation and inadequate vasoactive responses are mechanisms implicated in obstetric complications, and alterations in maternal plasma cytokine profile and nitric oxide (NO) metabolites are potential predictive biomarkers. We aimed to assess if these parameters are influenced by fetal sex. A prospective, observational study was carried out in 85 healthy pregnant women with singleton pregnancies in the first trimester of gestation. A blood sample was extracted at the tenth week of gestation. In plasma, we assessed: 1) cytokines (micro-array): pro-inflammatory (IL1α, IL1 β, IL6, TNFα), anti-inflammatory (IL4, IL10, IL13), and chemoattractant (IL8, MCP1, IFNγ), and 2) NO metabolites (liquid chromatography-tandem mass spectrometry and Griess reaction): L-arginine, ADMA, SDMA, nitrates (NOx). Women with a male fetus (n = 50) exhibited, compared with those with a female (n = 35): higher IL1β (OR = 1.09 with 95% CI: 0.97-1.28), and lower IL13 (OR = 0.93 with 95% CI: 0.87-0.99), and higher plasma NOx (OR = 1.14 with 95% CI: 1.03-1.31). Our data suggest that fetal sex influences maternal plasma cytokine profile and NO in early pregnancy. Women with a male fetus may have a worse capacity to counteract an inflammatory response. They may have better vasodilator capacity, but in the presence of an oxidative environment, a higher nitrosative damage may occur. These data reinforce the need to include sex as variable in predictive models.

AB - Male fetal sex associates with higher rates of materno-fetal complications. Inflammation and inadequate vasoactive responses are mechanisms implicated in obstetric complications, and alterations in maternal plasma cytokine profile and nitric oxide (NO) metabolites are potential predictive biomarkers. We aimed to assess if these parameters are influenced by fetal sex. A prospective, observational study was carried out in 85 healthy pregnant women with singleton pregnancies in the first trimester of gestation. A blood sample was extracted at the tenth week of gestation. In plasma, we assessed: 1) cytokines (micro-array): pro-inflammatory (IL1α, IL1 β, IL6, TNFα), anti-inflammatory (IL4, IL10, IL13), and chemoattractant (IL8, MCP1, IFNγ), and 2) NO metabolites (liquid chromatography-tandem mass spectrometry and Griess reaction): L-arginine, ADMA, SDMA, nitrates (NOx). Women with a male fetus (n = 50) exhibited, compared with those with a female (n = 35): higher IL1β (OR = 1.09 with 95% CI: 0.97-1.28), and lower IL13 (OR = 0.93 with 95% CI: 0.87-0.99), and higher plasma NOx (OR = 1.14 with 95% CI: 1.03-1.31). Our data suggest that fetal sex influences maternal plasma cytokine profile and NO in early pregnancy. Women with a male fetus may have a worse capacity to counteract an inflammatory response. They may have better vasodilator capacity, but in the presence of an oxidative environment, a higher nitrosative damage may occur. These data reinforce the need to include sex as variable in predictive models.

U2 - 10.1016/j.cyto.2020.155290

DO - 10.1016/j.cyto.2020.155290

M3 - SCORING: Journal article

C2 - 32956948

VL - 136

SP - 155290

JO - CYTOKINE

JF - CYTOKINE

SN - 1043-4666

ER -