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Major liver resections in the elderly-is an aggressive approach justified?

Standard

Major liver resections in the elderly-is an aggressive approach justified? / Bockhorn, Maximilian; Sotiropoulos, Georgios C; Sgourakis, George; Neuhaus, Jan P; Molmenti, Ernesto P; Lang, Hauke; Frilling, Andreja; Broelsch, Christoph E.

In: INT J COLORECTAL DIS, Vol. 24, No. 1, 1, 2009, p. 83-86.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bockhorn, M, Sotiropoulos, GC, Sgourakis, G, Neuhaus, JP, Molmenti, EP, Lang, H, Frilling, A & Broelsch, CE 2009, 'Major liver resections in the elderly-is an aggressive approach justified?', INT J COLORECTAL DIS, vol. 24, no. 1, 1, pp. 83-86. <http://www.ncbi.nlm.nih.gov/pubmed/18766356?dopt=Citation>

APA

Bockhorn, M., Sotiropoulos, G. C., Sgourakis, G., Neuhaus, J. P., Molmenti, E. P., Lang, H., Frilling, A., & Broelsch, C. E. (2009). Major liver resections in the elderly-is an aggressive approach justified? INT J COLORECTAL DIS, 24(1), 83-86. [1]. http://www.ncbi.nlm.nih.gov/pubmed/18766356?dopt=Citation

Vancouver

Bockhorn M, Sotiropoulos GC, Sgourakis G, Neuhaus JP, Molmenti EP, Lang H et al. Major liver resections in the elderly-is an aggressive approach justified? INT J COLORECTAL DIS. 2009;24(1):83-86. 1.

Bibtex

@article{8fe8b15a8472443d9a7da49fd2398894,
title = "Major liver resections in the elderly-is an aggressive approach justified?",
abstract = "BACKGROUND AND AIMS: As the mean life expectancy rises, the incidence of patients 75 years of age and older who present with colorectal liver metastases continues to increase. The purpose of our study was to evaluate the outcome of major hepatic resections in the elderly population. PATIENT AND METHODS: From April 1998 to December 2006, 572 consecutive patients with colorectal liver metastases were treated at our Institution. Of these, 59 were 75 years or older. There was an intent to proceed with major liver resections in all cases. Data were analyzed according to diagnosis, comorbidities, extent of liver resection, postoperative complications, overall survival, and disease-free survival. RESULTS: Surgical treatment included right hepatectomies (n = 8), left hepatectomies (n = 4), and sectionectomies (more than three segments; n = 33). Fourteen (n = 14) patients received an explorative laparotomy alone. Morbidity and hospital mortality were 10% and 3%, respectively. Overall survival of 1, 3, and 5 years was 90%, 64%, and 33%, respectively. The corresponding disease-free survival was 74%, 42%, and 32%. Resection margin (R class) was the only predictor of survival by both uni- and multivariate analyses. CONCLUSION: Hepatic resections can be performed safely in selected patients 75 years of age or older.",
keywords = "Comorbidity, Humans, Male, Aged, Female, Aged, 80 and over, Disease-Free Survival, Proportional Hazards Models, Hepatectomy methods, Liver Neoplasms mortality, Colorectal Neoplasms pathology, Hospital Mortality, Postoperative Complications, Comorbidity, Humans, Male, Aged, Female, Aged, 80 and over, Disease-Free Survival, Proportional Hazards Models, Hepatectomy methods, Liver Neoplasms mortality, Colorectal Neoplasms pathology, Hospital Mortality, Postoperative Complications",
author = "Maximilian Bockhorn and Sotiropoulos, {Georgios C} and George Sgourakis and Neuhaus, {Jan P} and Molmenti, {Ernesto P} and Hauke Lang and Andreja Frilling and Broelsch, {Christoph E}",
year = "2009",
language = "Deutsch",
volume = "24",
pages = "83--86",
journal = "INT J COLORECTAL DIS",
issn = "0179-1958",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Major liver resections in the elderly-is an aggressive approach justified?

AU - Bockhorn, Maximilian

AU - Sotiropoulos, Georgios C

AU - Sgourakis, George

AU - Neuhaus, Jan P

AU - Molmenti, Ernesto P

AU - Lang, Hauke

AU - Frilling, Andreja

AU - Broelsch, Christoph E

PY - 2009

Y1 - 2009

N2 - BACKGROUND AND AIMS: As the mean life expectancy rises, the incidence of patients 75 years of age and older who present with colorectal liver metastases continues to increase. The purpose of our study was to evaluate the outcome of major hepatic resections in the elderly population. PATIENT AND METHODS: From April 1998 to December 2006, 572 consecutive patients with colorectal liver metastases were treated at our Institution. Of these, 59 were 75 years or older. There was an intent to proceed with major liver resections in all cases. Data were analyzed according to diagnosis, comorbidities, extent of liver resection, postoperative complications, overall survival, and disease-free survival. RESULTS: Surgical treatment included right hepatectomies (n = 8), left hepatectomies (n = 4), and sectionectomies (more than three segments; n = 33). Fourteen (n = 14) patients received an explorative laparotomy alone. Morbidity and hospital mortality were 10% and 3%, respectively. Overall survival of 1, 3, and 5 years was 90%, 64%, and 33%, respectively. The corresponding disease-free survival was 74%, 42%, and 32%. Resection margin (R class) was the only predictor of survival by both uni- and multivariate analyses. CONCLUSION: Hepatic resections can be performed safely in selected patients 75 years of age or older.

AB - BACKGROUND AND AIMS: As the mean life expectancy rises, the incidence of patients 75 years of age and older who present with colorectal liver metastases continues to increase. The purpose of our study was to evaluate the outcome of major hepatic resections in the elderly population. PATIENT AND METHODS: From April 1998 to December 2006, 572 consecutive patients with colorectal liver metastases were treated at our Institution. Of these, 59 were 75 years or older. There was an intent to proceed with major liver resections in all cases. Data were analyzed according to diagnosis, comorbidities, extent of liver resection, postoperative complications, overall survival, and disease-free survival. RESULTS: Surgical treatment included right hepatectomies (n = 8), left hepatectomies (n = 4), and sectionectomies (more than three segments; n = 33). Fourteen (n = 14) patients received an explorative laparotomy alone. Morbidity and hospital mortality were 10% and 3%, respectively. Overall survival of 1, 3, and 5 years was 90%, 64%, and 33%, respectively. The corresponding disease-free survival was 74%, 42%, and 32%. Resection margin (R class) was the only predictor of survival by both uni- and multivariate analyses. CONCLUSION: Hepatic resections can be performed safely in selected patients 75 years of age or older.

KW - Comorbidity

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Proportional Hazards Models

KW - Hepatectomy methods

KW - Liver Neoplasms mortality

KW - Colorectal Neoplasms pathology

KW - Hospital Mortality

KW - Postoperative Complications

KW - Comorbidity

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Proportional Hazards Models

KW - Hepatectomy methods

KW - Liver Neoplasms mortality

KW - Colorectal Neoplasms pathology

KW - Hospital Mortality

KW - Postoperative Complications

M3 - SCORING: Zeitschriftenaufsatz

VL - 24

SP - 83

EP - 86

JO - INT J COLORECTAL DIS

JF - INT J COLORECTAL DIS

SN - 0179-1958

IS - 1

M1 - 1

ER -