Major adverse cardiac and cerebrovascular events after the Ross procedure: a report from the German-Dutch Ross Registry
Standard
Major adverse cardiac and cerebrovascular events after the Ross procedure: a report from the German-Dutch Ross Registry. / Sievers, Hans-H; Stierle, Ulrich; Charitos, Efstratios I; Hanke, Thorsten; Misfeld, Martin; Matthias Bechtel, J F; Gorski, Armin; Franke, Ulrich F W; Graf, Bernhard; Robinson, Derek R; Bogers, Ad J J C; Dodge-Khatami, Ali; Boehm, Juergen O; Rein, Joachim G; Botha, Cornelius A; Lange, Ruediger; Hoerer, Juergen; Moritz, Anton; Wahlers, Thorsten; Breuer, Martin; Ferrari-Kuehne, Katharina; Hetzer, Roland; Huebler, Michael; Ziemer, Gerhard; Takkenberg, Johanna J M; Hemmer, Wolfgang; German-Dutch Ross Registry.
In: CIRCULATION, Vol. 122, No. 11 Suppl, 14.09.2010, p. 216-223.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Major adverse cardiac and cerebrovascular events after the Ross procedure: a report from the German-Dutch Ross Registry
AU - Sievers, Hans-H
AU - Stierle, Ulrich
AU - Charitos, Efstratios I
AU - Hanke, Thorsten
AU - Misfeld, Martin
AU - Matthias Bechtel, J F
AU - Gorski, Armin
AU - Franke, Ulrich F W
AU - Graf, Bernhard
AU - Robinson, Derek R
AU - Bogers, Ad J J C
AU - Dodge-Khatami, Ali
AU - Boehm, Juergen O
AU - Rein, Joachim G
AU - Botha, Cornelius A
AU - Lange, Ruediger
AU - Hoerer, Juergen
AU - Moritz, Anton
AU - Wahlers, Thorsten
AU - Breuer, Martin
AU - Ferrari-Kuehne, Katharina
AU - Hetzer, Roland
AU - Huebler, Michael
AU - Ziemer, Gerhard
AU - Takkenberg, Johanna J M
AU - Hemmer, Wolfgang
AU - German-Dutch Ross Registry
PY - 2010/9/14
Y1 - 2010/9/14
N2 - BACKGROUND: The purpose of the study is to report major cardiac and cerebrovascular events after the Ross procedure in the large adult and pediatric population of the German-Dutch Ross registry. These data could provide an additional basis for discussions among physicians and a source of information for patients.METHODS AND RESULTS: One thousand six hundred twenty patients (1420 adults; 1211 male; mean age, 39.2±16.2 years) underwent a Ross procedure between 1988 and 2008. Follow-up was performed on an annual basis (median, 6.2 years; 10 747 patient-years). Early and late mortality were 1.2% (n=19) and 3.6% (n=58; 0.54%/patient-year), respectively. Ninety-three patients underwent 99 reinterventions on the autograft (0.92%/patient-year); 78 reinterventions in 63 patients on the pulmonary conduit were performed (0.73%/patient-year). Freedom from autograft or pulmonary conduit reoperation was 98.2%, 95.1%, and 89% at 1, 5, and 10 years, respectively. Preoperative aortic regurgitation and the root replacement technique without surgical autograft reinforcement were associated with a greater hazard for autograft reoperation. Major internal or external bleeding occurred in 17 (0.15%/patient-year), and a total of 38 patients had composite end point of thrombosis, embolism, or bleeding (0.35%/patient-year). Late endocarditis with medical (n=16) or surgical treatment (n=29) was observed in 38 patients (0.38%/patient-year). Freedom from any valve-related event was 94.9% at 1 year, 90.7% at 5 years, and 82.5% at 10 years.CONCLUSIONS: Although longer follow-up of patients who undergo Ross operation is needed, the present series confirms that the autograft procedure is a valid option to treat aortic valve disease in selected patients. The nonreinforced full root technique and preoperative aortic regurgitation are predictors for autograft failure and warrant further consideration. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00708409.
AB - BACKGROUND: The purpose of the study is to report major cardiac and cerebrovascular events after the Ross procedure in the large adult and pediatric population of the German-Dutch Ross registry. These data could provide an additional basis for discussions among physicians and a source of information for patients.METHODS AND RESULTS: One thousand six hundred twenty patients (1420 adults; 1211 male; mean age, 39.2±16.2 years) underwent a Ross procedure between 1988 and 2008. Follow-up was performed on an annual basis (median, 6.2 years; 10 747 patient-years). Early and late mortality were 1.2% (n=19) and 3.6% (n=58; 0.54%/patient-year), respectively. Ninety-three patients underwent 99 reinterventions on the autograft (0.92%/patient-year); 78 reinterventions in 63 patients on the pulmonary conduit were performed (0.73%/patient-year). Freedom from autograft or pulmonary conduit reoperation was 98.2%, 95.1%, and 89% at 1, 5, and 10 years, respectively. Preoperative aortic regurgitation and the root replacement technique without surgical autograft reinforcement were associated with a greater hazard for autograft reoperation. Major internal or external bleeding occurred in 17 (0.15%/patient-year), and a total of 38 patients had composite end point of thrombosis, embolism, or bleeding (0.35%/patient-year). Late endocarditis with medical (n=16) or surgical treatment (n=29) was observed in 38 patients (0.38%/patient-year). Freedom from any valve-related event was 94.9% at 1 year, 90.7% at 5 years, and 82.5% at 10 years.CONCLUSIONS: Although longer follow-up of patients who undergo Ross operation is needed, the present series confirms that the autograft procedure is a valid option to treat aortic valve disease in selected patients. The nonreinforced full root technique and preoperative aortic regurgitation are predictors for autograft failure and warrant further consideration. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00708409.
KW - Adult
KW - Aortic Valve/surgery
KW - Aortic Valve Insufficiency/mortality
KW - Endocarditis/etiology
KW - Female
KW - Follow-Up Studies
KW - Germany
KW - Hemorrhage/etiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Netherlands
KW - Postoperative Complications/mortality
KW - Registries
KW - Transplantation, Autologous
U2 - 10.1161/CIRCULATIONAHA.109.925800
DO - 10.1161/CIRCULATIONAHA.109.925800
M3 - SCORING: Journal article
C2 - 20837916
VL - 122
SP - 216
EP - 223
JO - CIRCULATION
JF - CIRCULATION
SN - 0009-7322
IS - 11 Suppl
ER -