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Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model.

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Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model. / Dahl, Anka; Peldschus, Kersten; Ittrich, Harald; Adam, Gerhard; Altevogt, Peter; Wagener, Christoph; Schumacher, Udo.

In: CANCER LETT, Vol. 274, No. 2, 2, 2009, p. 194-200.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dahl, A, Peldschus, K, Ittrich, H, Adam, G, Altevogt, P, Wagener, C & Schumacher, U 2009, 'Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model.', CANCER LETT, vol. 274, no. 2, 2, pp. 194-200. <http://www.ncbi.nlm.nih.gov/pubmed/18922631?dopt=Citation>

APA

Dahl, A., Peldschus, K., Ittrich, H., Adam, G., Altevogt, P., Wagener, C., & Schumacher, U. (2009). Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model. CANCER LETT, 274(2), 194-200. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18922631?dopt=Citation

Vancouver

Dahl A, Peldschus K, Ittrich H, Adam G, Altevogt P, Wagener C et al. Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model. CANCER LETT. 2009;274(2):194-200. 2.

Bibtex

@article{1c7647b133a844788b32b54b263a53da,
title = "Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model.",
abstract = "This study aimed to analyse (i) the metastatic behaviour of human melanoma FEMX-1 cells in scid mice after surgical excision of the PT and (ii) to evaluate the feasibility of magnetic resonance imaging (MRI) for the detection of melanoma metastases. Histology proved both high specificity (95%), and high sensitivity of MRI detection of melanoma metastasis. CEACAM1, L1, and HPA-binding site expression, all markers predicting metastasis in clinical studies, were preserved in the metastatic nodules. Thus, our xenograft model closely resembles the clinical situation of post-operative development of distant organ metastasis and demonstrates that MRI is a sensitive and highly qualified technology for intra-vital monitoring of melanoma progression.",
author = "Anka Dahl and Kersten Peldschus and Harald Ittrich and Gerhard Adam and Peter Altevogt and Christoph Wagener and Udo Schumacher",
year = "2009",
language = "Deutsch",
volume = "274",
pages = "194--200",
journal = "CANCER LETT",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model.

AU - Dahl, Anka

AU - Peldschus, Kersten

AU - Ittrich, Harald

AU - Adam, Gerhard

AU - Altevogt, Peter

AU - Wagener, Christoph

AU - Schumacher, Udo

PY - 2009

Y1 - 2009

N2 - This study aimed to analyse (i) the metastatic behaviour of human melanoma FEMX-1 cells in scid mice after surgical excision of the PT and (ii) to evaluate the feasibility of magnetic resonance imaging (MRI) for the detection of melanoma metastases. Histology proved both high specificity (95%), and high sensitivity of MRI detection of melanoma metastasis. CEACAM1, L1, and HPA-binding site expression, all markers predicting metastasis in clinical studies, were preserved in the metastatic nodules. Thus, our xenograft model closely resembles the clinical situation of post-operative development of distant organ metastasis and demonstrates that MRI is a sensitive and highly qualified technology for intra-vital monitoring of melanoma progression.

AB - This study aimed to analyse (i) the metastatic behaviour of human melanoma FEMX-1 cells in scid mice after surgical excision of the PT and (ii) to evaluate the feasibility of magnetic resonance imaging (MRI) for the detection of melanoma metastases. Histology proved both high specificity (95%), and high sensitivity of MRI detection of melanoma metastasis. CEACAM1, L1, and HPA-binding site expression, all markers predicting metastasis in clinical studies, were preserved in the metastatic nodules. Thus, our xenograft model closely resembles the clinical situation of post-operative development of distant organ metastasis and demonstrates that MRI is a sensitive and highly qualified technology for intra-vital monitoring of melanoma progression.

M3 - SCORING: Zeitschriftenaufsatz

VL - 274

SP - 194

EP - 200

JO - CANCER LETT

JF - CANCER LETT

SN - 0304-3835

IS - 2

M1 - 2

ER -