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Magnetic resonance imaging for precise radiotherapy of small laboratory animals

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Magnetic resonance imaging for precise radiotherapy of small laboratory animals. / Frenzel, Thorsten; Kaul, Michael Gerhard; Ernst, Thomas Michael; Salamon, Johannes; Jäckel, Maria; Schumacher, Udo; Krüll, Andreas.

In: Z MED PHYS, Vol. 27, 2017, p. 6-12.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Frenzel, T, Kaul, MG, Ernst, TM, Salamon, J, Jäckel, M, Schumacher, U & Krüll, A 2017, 'Magnetic resonance imaging for precise radiotherapy of small laboratory animals', Z MED PHYS, vol. 27, pp. 6-12. https://doi.org/10.1016/j.zemedi.2016.05.002

APA

Frenzel, T., Kaul, M. G., Ernst, T. M., Salamon, J., Jäckel, M., Schumacher, U., & Krüll, A. (2017). Magnetic resonance imaging for precise radiotherapy of small laboratory animals. Z MED PHYS, 27, 6-12. https://doi.org/10.1016/j.zemedi.2016.05.002

Vancouver

Frenzel T, Kaul MG, Ernst TM, Salamon J, Jäckel M, Schumacher U et al. Magnetic resonance imaging for precise radiotherapy of small laboratory animals. Z MED PHYS. 2017;27:6-12. https://doi.org/10.1016/j.zemedi.2016.05.002

Bibtex

@article{bcd22d0dcbbc476d8389688b71defc7d,
title = "Magnetic resonance imaging for precise radiotherapy of small laboratory animals",
abstract = "AIMS: Radiotherapy of small laboratory animals (SLA) is often not as precisely applied as in humans. Here we describe the use of a dedicated SLA magnetic resonance imaging (MRI) scanner for precise tumor volumetry, radiotherapy treatment planning, and diagnostic imaging in order to make the experiments more accurate.METHODS AND MATERIALS: Different human cancer cells were injected at the lower trunk of pfp/rag2 and SCID mice to allow for local tumor growth. Data from cross sectional MRI scans were transferred to a clinical treatment planning system (TPS) for humans. Manual palpation of the tumor size was compared with calculated tumor size of the TPS and with tumor weight at necropsy. As a feasibility study MRI based treatment plans were calculated for a clinical 6MV linear accelerator using a micro multileaf collimator (μMLC). In addition, diagnostic MRI scans were used to investigate animals which did clinical poorly during the study.RESULTS: MRI is superior in precise tumor volume definition whereas manual palpation underestimates their size. Cross sectional MRI allow for treatment planning so that conformal irradiation of mice with a clinical linear accelerator using a μMLC is in principle feasible. Several internal pathologies were detected during the experiment using the dedicated scanner.CONCLUSION: MRI is a key technology for precise radiotherapy of SLA. The scanning protocols provided are suited for tumor volumetry, treatment planning, and diagnostic imaging.",
author = "Thorsten Frenzel and Kaul, {Michael Gerhard} and Ernst, {Thomas Michael} and Johannes Salamon and Maria J{\"a}ckel and Udo Schumacher and Andreas Kr{\"u}ll",
note = "Copyright {\textcopyright} 2016. Published by Elsevier GmbH.",
year = "2017",
doi = "10.1016/j.zemedi.2016.05.002",
language = "English",
volume = "27",
pages = "6--12",
journal = "Z MED PHYS",
issn = "0939-3889",
publisher = "Urban und Fischer Verlag Jena",

}

RIS

TY - JOUR

T1 - Magnetic resonance imaging for precise radiotherapy of small laboratory animals

AU - Frenzel, Thorsten

AU - Kaul, Michael Gerhard

AU - Ernst, Thomas Michael

AU - Salamon, Johannes

AU - Jäckel, Maria

AU - Schumacher, Udo

AU - Krüll, Andreas

N1 - Copyright © 2016. Published by Elsevier GmbH.

PY - 2017

Y1 - 2017

N2 - AIMS: Radiotherapy of small laboratory animals (SLA) is often not as precisely applied as in humans. Here we describe the use of a dedicated SLA magnetic resonance imaging (MRI) scanner for precise tumor volumetry, radiotherapy treatment planning, and diagnostic imaging in order to make the experiments more accurate.METHODS AND MATERIALS: Different human cancer cells were injected at the lower trunk of pfp/rag2 and SCID mice to allow for local tumor growth. Data from cross sectional MRI scans were transferred to a clinical treatment planning system (TPS) for humans. Manual palpation of the tumor size was compared with calculated tumor size of the TPS and with tumor weight at necropsy. As a feasibility study MRI based treatment plans were calculated for a clinical 6MV linear accelerator using a micro multileaf collimator (μMLC). In addition, diagnostic MRI scans were used to investigate animals which did clinical poorly during the study.RESULTS: MRI is superior in precise tumor volume definition whereas manual palpation underestimates their size. Cross sectional MRI allow for treatment planning so that conformal irradiation of mice with a clinical linear accelerator using a μMLC is in principle feasible. Several internal pathologies were detected during the experiment using the dedicated scanner.CONCLUSION: MRI is a key technology for precise radiotherapy of SLA. The scanning protocols provided are suited for tumor volumetry, treatment planning, and diagnostic imaging.

AB - AIMS: Radiotherapy of small laboratory animals (SLA) is often not as precisely applied as in humans. Here we describe the use of a dedicated SLA magnetic resonance imaging (MRI) scanner for precise tumor volumetry, radiotherapy treatment planning, and diagnostic imaging in order to make the experiments more accurate.METHODS AND MATERIALS: Different human cancer cells were injected at the lower trunk of pfp/rag2 and SCID mice to allow for local tumor growth. Data from cross sectional MRI scans were transferred to a clinical treatment planning system (TPS) for humans. Manual palpation of the tumor size was compared with calculated tumor size of the TPS and with tumor weight at necropsy. As a feasibility study MRI based treatment plans were calculated for a clinical 6MV linear accelerator using a micro multileaf collimator (μMLC). In addition, diagnostic MRI scans were used to investigate animals which did clinical poorly during the study.RESULTS: MRI is superior in precise tumor volume definition whereas manual palpation underestimates their size. Cross sectional MRI allow for treatment planning so that conformal irradiation of mice with a clinical linear accelerator using a μMLC is in principle feasible. Several internal pathologies were detected during the experiment using the dedicated scanner.CONCLUSION: MRI is a key technology for precise radiotherapy of SLA. The scanning protocols provided are suited for tumor volumetry, treatment planning, and diagnostic imaging.

U2 - 10.1016/j.zemedi.2016.05.002

DO - 10.1016/j.zemedi.2016.05.002

M3 - SCORING: Journal article

C2 - 27312789

VL - 27

SP - 6

EP - 12

JO - Z MED PHYS

JF - Z MED PHYS

SN - 0939-3889

ER -