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Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium

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Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. / Koebernick, Heidrun; Grode, Leander; David, John R; Rohde, Wolfgang; Rolph, Michael S; Mittrücker, Hans-Willi; Kaufmann, Stefan H E.

In: P NATL ACAD SCI USA, Vol. 99, No. 21, 15.10.2002, p. 13681-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Koebernick, H, Grode, L, David, JR, Rohde, W, Rolph, MS, Mittrücker, H-W & Kaufmann, SHE 2002, 'Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium', P NATL ACAD SCI USA, vol. 99, no. 21, pp. 13681-6. https://doi.org/10.1073/pnas.212488699

APA

Koebernick, H., Grode, L., David, J. R., Rohde, W., Rolph, M. S., Mittrücker, H-W., & Kaufmann, S. H. E. (2002). Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. P NATL ACAD SCI USA, 99(21), 13681-6. https://doi.org/10.1073/pnas.212488699

Vancouver

Koebernick H, Grode L, David JR, Rohde W, Rolph MS, Mittrücker H-W et al. Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. P NATL ACAD SCI USA. 2002 Oct 15;99(21):13681-6. https://doi.org/10.1073/pnas.212488699

Bibtex

@article{204c70a1e31e411cb6ee4a238ec5d563,
title = "Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium",
abstract = "The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the hypothalamus-pituitary-adrenal stress axis. The role of MIF in infectious diseases is not understood completely. Here, we show that MIF-deficient (MIF(-/-)) knockout mice fail to control an infection with wild-type Salmonella typhimurium. Increased susceptibility was accompanied by a reduced Th1 response, demonstrated by decreased levels of IL-12, IFNgamma, and tumor necrosis factor alpha. In Salmonella-infected MIF(-/-) mice, levels of IL-1beta were markedly increased. Additionally, infected MIF(-/-) mice showed elevated serum levels of nitric oxide and corticosterone as compared with control mice. Our results point to MIF as a key mediator in the host response to S. typhimurium. MIF not only promotes development of a protective Th1 response but ameliorates disease by altering levels of reactive nitrogen intermediates and corticosteroid hormones, which both exert immunosuppressive functions.",
keywords = "Animals, Corticosterone, Inflammation Mediators, Interferon-gamma, Interleukin-12, Macrophage Migration-Inhibitory Factors, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nitric Oxide, Salmonella Infections, Salmonella typhimurium, Th1 Cells, Tumor Necrosis Factor-alpha",
author = "Heidrun Koebernick and Leander Grode and David, {John R} and Wolfgang Rohde and Rolph, {Michael S} and Hans-Willi Mittr{\"u}cker and Kaufmann, {Stefan H E}",
year = "2002",
month = oct,
day = "15",
doi = "10.1073/pnas.212488699",
language = "English",
volume = "99",
pages = "13681--6",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "21",

}

RIS

TY - JOUR

T1 - Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium

AU - Koebernick, Heidrun

AU - Grode, Leander

AU - David, John R

AU - Rohde, Wolfgang

AU - Rolph, Michael S

AU - Mittrücker, Hans-Willi

AU - Kaufmann, Stefan H E

PY - 2002/10/15

Y1 - 2002/10/15

N2 - The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the hypothalamus-pituitary-adrenal stress axis. The role of MIF in infectious diseases is not understood completely. Here, we show that MIF-deficient (MIF(-/-)) knockout mice fail to control an infection with wild-type Salmonella typhimurium. Increased susceptibility was accompanied by a reduced Th1 response, demonstrated by decreased levels of IL-12, IFNgamma, and tumor necrosis factor alpha. In Salmonella-infected MIF(-/-) mice, levels of IL-1beta were markedly increased. Additionally, infected MIF(-/-) mice showed elevated serum levels of nitric oxide and corticosterone as compared with control mice. Our results point to MIF as a key mediator in the host response to S. typhimurium. MIF not only promotes development of a protective Th1 response but ameliorates disease by altering levels of reactive nitrogen intermediates and corticosteroid hormones, which both exert immunosuppressive functions.

AB - The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the hypothalamus-pituitary-adrenal stress axis. The role of MIF in infectious diseases is not understood completely. Here, we show that MIF-deficient (MIF(-/-)) knockout mice fail to control an infection with wild-type Salmonella typhimurium. Increased susceptibility was accompanied by a reduced Th1 response, demonstrated by decreased levels of IL-12, IFNgamma, and tumor necrosis factor alpha. In Salmonella-infected MIF(-/-) mice, levels of IL-1beta were markedly increased. Additionally, infected MIF(-/-) mice showed elevated serum levels of nitric oxide and corticosterone as compared with control mice. Our results point to MIF as a key mediator in the host response to S. typhimurium. MIF not only promotes development of a protective Th1 response but ameliorates disease by altering levels of reactive nitrogen intermediates and corticosteroid hormones, which both exert immunosuppressive functions.

KW - Animals

KW - Corticosterone

KW - Inflammation Mediators

KW - Interferon-gamma

KW - Interleukin-12

KW - Macrophage Migration-Inhibitory Factors

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Nitric Oxide

KW - Salmonella Infections

KW - Salmonella typhimurium

KW - Th1 Cells

KW - Tumor Necrosis Factor-alpha

U2 - 10.1073/pnas.212488699

DO - 10.1073/pnas.212488699

M3 - SCORING: Journal article

C2 - 12271144

VL - 99

SP - 13681

EP - 13686

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 21

ER -