Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
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Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. / Bosurgi, Lidia; Cao, Y Grace; Cabeza-Cabrerizo, Mar; Tucci, Andrea; Hughes, Lindsey D; Kong, Yong; Weinstein, Jason S; Licona-Limon, Paula; Schmid, Edward T; Pelorosso, Facundo; Gagliani, Nicola; Craft, Joseph E; Flavell, Richard A; Ghosh, Sourav; Rothlin, Carla V.
In: SCIENCE, Vol. 356, No. 6342, 09.06.2017, p. 1072-1076.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
AU - Bosurgi, Lidia
AU - Cao, Y Grace
AU - Cabeza-Cabrerizo, Mar
AU - Tucci, Andrea
AU - Hughes, Lindsey D
AU - Kong, Yong
AU - Weinstein, Jason S
AU - Licona-Limon, Paula
AU - Schmid, Edward T
AU - Pelorosso, Facundo
AU - Gagliani, Nicola
AU - Craft, Joseph E
AU - Flavell, Richard A
AU - Ghosh, Sourav
AU - Rothlin, Carla V
N1 - Copyright © 2017, American Association for the Advancement of Science.
PY - 2017/6/9
Y1 - 2017/6/9
N2 - Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)- and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macrophages. Genetic ablation of sensors of apoptotic cells impaired the proliferation of tissue-resident macrophages and the induction of anti-inflammatory and tissue repair genes in the lungs after helminth infection or in the gut after induction of colitis. By contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotaxis genes in macrophages. Detection of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.
AB - Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)- and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macrophages. Genetic ablation of sensors of apoptotic cells impaired the proliferation of tissue-resident macrophages and the induction of anti-inflammatory and tissue repair genes in the lungs after helminth infection or in the gut after induction of colitis. By contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotaxis genes in macrophages. Detection of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Research Support, N.I.H., Extramural
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85019188120&partnerID=MN8TOARS
U2 - 10.1126/science.aai8132
DO - 10.1126/science.aai8132
M3 - SCORING: Journal article
C2 - 28495875
VL - 356
SP - 1072
EP - 1076
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 6342
ER -