Lymphocytes, neuropeptides, and genes involved in alopecia areata.
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Lymphocytes, neuropeptides, and genes involved in alopecia areata. / Gilhar, Amos; Paus, Ralf; Kalish, Richard S.
In: J CLIN INVEST, Vol. 117, No. 8, 8, 2007, p. 2019-2027.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Lymphocytes, neuropeptides, and genes involved in alopecia areata.
AU - Gilhar, Amos
AU - Paus, Ralf
AU - Kalish, Richard S
PY - 2007
Y1 - 2007
N2 - Many lessons in autoimmunity - particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology - can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell-mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community.
AB - Many lessons in autoimmunity - particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology - can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell-mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community.
M3 - SCORING: Zeitschriftenaufsatz
VL - 117
SP - 2019
EP - 2027
JO - J CLIN INVEST
JF - J CLIN INVEST
SN - 0021-9738
IS - 8
M1 - 8
ER -