Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imaging.
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Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imaging. / Goebell, Einar; Paustenbach, Susanne; Vaeterlein, Ole; Ding, Xiao-Qi; Heese, Oliver; Fiehler, Jens; Kucinski, Thomas; Hagel, Christian; Westphal, Manfred; Zeumer, Hermann.
In: RADIOLOGY, Vol. 239, No. 1, 1, 01.04.2006, p. 217-222.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imaging.
AU - Goebell, Einar
AU - Paustenbach, Susanne
AU - Vaeterlein, Ole
AU - Ding, Xiao-Qi
AU - Heese, Oliver
AU - Fiehler, Jens
AU - Kucinski, Thomas
AU - Hagel, Christian
AU - Westphal, Manfred
AU - Zeumer, Hermann
PY - 2006/4/1
Y1 - 2006/4/1
N2 - PURPOSE: To prospectively evaluate whether diffusion-tensor magnetic resonance (MR) imaging depicts differences in World Health Organization (WHO) grade II and III glial brain tumors on the basis of tumor architecture and peritumoral tract invasion. MATERIALS AND METHODS: The study protocol was approved by the local ethics committee, and written informed consent was obtained. Diffusion-tensor MR imaging was performed in 23 patients (15 men, eight women; mean age, 47 years) with histologically confirmed brain gliomas. Eleven of the 23 tumors were low-grade gliomas (WHO grade II) and 12 were anaplastic gliomas (WHO grade III). Regions of interest were placed in the tumor center, tumor border, normal-appearing white matter (NAWM) adjacent to the tumor, and NAWM of the contralateral hemisphere. fractional anisotropy (FA) ratios were calculated for regions of interest in relation to the NAWM of the contralateral hemisphere. Pairwise comparisons were performed by using the Mann-Whitney U test. RESULTS: Median FA ratios for grade II versus grade III gliomas were 0.406 versus 0.405, respectively, for tumor center, 0.733 versus 0.449, respectively, for tumor border, and 0.962 versus 0.943, respectively, for NAWM adjacent to the tumor. Differences in FA ratio between low-grade and high-grade tumors were significant in the tumor border only (P = .01). Differences in FA ratio were not significant between low-grade and high-grade gliomas in the tumor center or in the NAWM adjacent to the tumor. CONCLUSION: The periphery of low-grade gliomas contains a considerable amount of preserved fiber tracts. In high-grade gliomas, however, most of these tracts are disarranged. Low FA ratios in the tumor center are consistent with a high degree of disorganization of myelinated fiber tracts in the center of both low-grade and high-grade gliomas.
AB - PURPOSE: To prospectively evaluate whether diffusion-tensor magnetic resonance (MR) imaging depicts differences in World Health Organization (WHO) grade II and III glial brain tumors on the basis of tumor architecture and peritumoral tract invasion. MATERIALS AND METHODS: The study protocol was approved by the local ethics committee, and written informed consent was obtained. Diffusion-tensor MR imaging was performed in 23 patients (15 men, eight women; mean age, 47 years) with histologically confirmed brain gliomas. Eleven of the 23 tumors were low-grade gliomas (WHO grade II) and 12 were anaplastic gliomas (WHO grade III). Regions of interest were placed in the tumor center, tumor border, normal-appearing white matter (NAWM) adjacent to the tumor, and NAWM of the contralateral hemisphere. fractional anisotropy (FA) ratios were calculated for regions of interest in relation to the NAWM of the contralateral hemisphere. Pairwise comparisons were performed by using the Mann-Whitney U test. RESULTS: Median FA ratios for grade II versus grade III gliomas were 0.406 versus 0.405, respectively, for tumor center, 0.733 versus 0.449, respectively, for tumor border, and 0.962 versus 0.943, respectively, for NAWM adjacent to the tumor. Differences in FA ratio between low-grade and high-grade tumors were significant in the tumor border only (P = .01). Differences in FA ratio were not significant between low-grade and high-grade gliomas in the tumor center or in the NAWM adjacent to the tumor. CONCLUSION: The periphery of low-grade gliomas contains a considerable amount of preserved fiber tracts. In high-grade gliomas, however, most of these tracts are disarranged. Low FA ratios in the tumor center are consistent with a high degree of disorganization of myelinated fiber tracts in the center of both low-grade and high-grade gliomas.
KW - Adult
KW - Aged
KW - Brain Neoplasms
KW - Diffusion Magnetic Resonance Imaging
KW - Female
KW - Glioma
KW - Humans
KW - Male
KW - Middle Aged
KW - Prospective Studies
U2 - 10.1148/radiol.2383050059
DO - 10.1148/radiol.2383050059
M3 - SCORING: Journal article
C2 - 16484348
VL - 239
SP - 217
EP - 222
JO - RADIOLOGY
JF - RADIOLOGY
SN - 0033-8419
IS - 1
M1 - 1
ER -