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Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience

Standard

Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience. / Diehl, Christian D; Pigorsch, Steffi U; Gempt, Jens; Krieg, Sandro M; Reitz, Silvia; Waltenberger, Maria; Barz, Melanie; Meyer, Hanno S; Wagner, Arthur; Wilkens, Jan; Wiestler, Benedikt; Zimmer, Claus; Meyer, Bernhard; Combs, Stephanie E.

In: CANCERS, Vol. 15, No. 1, 14, 20.12.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Diehl, CD, Pigorsch, SU, Gempt, J, Krieg, SM, Reitz, S, Waltenberger, M, Barz, M, Meyer, HS, Wagner, A, Wilkens, J, Wiestler, B, Zimmer, C, Meyer, B & Combs, SE 2022, 'Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience', CANCERS, vol. 15, no. 1, 14. https://doi.org/10.3390/cancers15010014

APA

Diehl, C. D., Pigorsch, S. U., Gempt, J., Krieg, S. M., Reitz, S., Waltenberger, M., Barz, M., Meyer, H. S., Wagner, A., Wilkens, J., Wiestler, B., Zimmer, C., Meyer, B., & Combs, S. E. (2022). Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience. CANCERS, 15(1), [14]. https://doi.org/10.3390/cancers15010014

Vancouver

Diehl CD, Pigorsch SU, Gempt J, Krieg SM, Reitz S, Waltenberger M et al. Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience. CANCERS. 2022 Dec 20;15(1). 14. https://doi.org/10.3390/cancers15010014

Bibtex

@article{d5861343a6f04df1a4e665ef96b05068,
title = "Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience",
abstract = "BACKGROUND: Resection followed by local radiation therapy (RT) is the standard of care for symptomatic brain metastases. However, the optimal technique, fractionation scheme and dose are still being debated. Lately, low-energy X-ray intraoperative RT (lex-IORT) has been of increasing interest.METHOD: Eighteen consecutive patients undergoing BM resection followed by immediate lex-IORT with 16-30 Gy applied to the spherical applicator were retrospectively analyzed. Demographic, RT-specific, radiographic and clinical data were reviewed to evaluate the effectiveness and safety of IORT for BM. Descriptive statistics and Kaplan-Meyer analysis were applied.RESULTS: The mean follow-up time was 10.8 months (range, 0-39 months). The estimated local control (LC), distant brain control (DBC) and overall survival (OS) at 12 months post IORT were 92.9% (95%-CI 79.3-100%), 71.4% (95%-CI 50.2-92.6%) and 58.0% (95%-CI 34.1-81.9%), respectively. Two patients developed radiation necrosis (11.1%) and wound infection (CTCAE grade III); both had additional adjuvant treatment after IORT. For five patients (27.8%), the time to the start or continuation of systemic treatment was ≤15 days and hence shorter than wound healing and adjuvant RT would have required.CONCLUSION: In accordance with previous series, this study demonstrates the effectiveness and safety of IORT in the management of brain metastases despite the small cohort and the retrospective characteristic of this analysis.",
author = "Diehl, {Christian D} and Pigorsch, {Steffi U} and Jens Gempt and Krieg, {Sandro M} and Silvia Reitz and Maria Waltenberger and Melanie Barz and Meyer, {Hanno S} and Arthur Wagner and Jan Wilkens and Benedikt Wiestler and Claus Zimmer and Bernhard Meyer and Combs, {Stephanie E}",
year = "2022",
month = dec,
day = "20",
doi = "10.3390/cancers15010014",
language = "English",
volume = "15",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

RIS

TY - JOUR

T1 - Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience

AU - Diehl, Christian D

AU - Pigorsch, Steffi U

AU - Gempt, Jens

AU - Krieg, Sandro M

AU - Reitz, Silvia

AU - Waltenberger, Maria

AU - Barz, Melanie

AU - Meyer, Hanno S

AU - Wagner, Arthur

AU - Wilkens, Jan

AU - Wiestler, Benedikt

AU - Zimmer, Claus

AU - Meyer, Bernhard

AU - Combs, Stephanie E

PY - 2022/12/20

Y1 - 2022/12/20

N2 - BACKGROUND: Resection followed by local radiation therapy (RT) is the standard of care for symptomatic brain metastases. However, the optimal technique, fractionation scheme and dose are still being debated. Lately, low-energy X-ray intraoperative RT (lex-IORT) has been of increasing interest.METHOD: Eighteen consecutive patients undergoing BM resection followed by immediate lex-IORT with 16-30 Gy applied to the spherical applicator were retrospectively analyzed. Demographic, RT-specific, radiographic and clinical data were reviewed to evaluate the effectiveness and safety of IORT for BM. Descriptive statistics and Kaplan-Meyer analysis were applied.RESULTS: The mean follow-up time was 10.8 months (range, 0-39 months). The estimated local control (LC), distant brain control (DBC) and overall survival (OS) at 12 months post IORT were 92.9% (95%-CI 79.3-100%), 71.4% (95%-CI 50.2-92.6%) and 58.0% (95%-CI 34.1-81.9%), respectively. Two patients developed radiation necrosis (11.1%) and wound infection (CTCAE grade III); both had additional adjuvant treatment after IORT. For five patients (27.8%), the time to the start or continuation of systemic treatment was ≤15 days and hence shorter than wound healing and adjuvant RT would have required.CONCLUSION: In accordance with previous series, this study demonstrates the effectiveness and safety of IORT in the management of brain metastases despite the small cohort and the retrospective characteristic of this analysis.

AB - BACKGROUND: Resection followed by local radiation therapy (RT) is the standard of care for symptomatic brain metastases. However, the optimal technique, fractionation scheme and dose are still being debated. Lately, low-energy X-ray intraoperative RT (lex-IORT) has been of increasing interest.METHOD: Eighteen consecutive patients undergoing BM resection followed by immediate lex-IORT with 16-30 Gy applied to the spherical applicator were retrospectively analyzed. Demographic, RT-specific, radiographic and clinical data were reviewed to evaluate the effectiveness and safety of IORT for BM. Descriptive statistics and Kaplan-Meyer analysis were applied.RESULTS: The mean follow-up time was 10.8 months (range, 0-39 months). The estimated local control (LC), distant brain control (DBC) and overall survival (OS) at 12 months post IORT were 92.9% (95%-CI 79.3-100%), 71.4% (95%-CI 50.2-92.6%) and 58.0% (95%-CI 34.1-81.9%), respectively. Two patients developed radiation necrosis (11.1%) and wound infection (CTCAE grade III); both had additional adjuvant treatment after IORT. For five patients (27.8%), the time to the start or continuation of systemic treatment was ≤15 days and hence shorter than wound healing and adjuvant RT would have required.CONCLUSION: In accordance with previous series, this study demonstrates the effectiveness and safety of IORT in the management of brain metastases despite the small cohort and the retrospective characteristic of this analysis.

U2 - 10.3390/cancers15010014

DO - 10.3390/cancers15010014

M3 - SCORING: Journal article

C2 - 36612015

VL - 15

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 1

M1 - 14

ER -