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Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

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Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms. / Chaarani, Bader; Kan, Kees-Jan; Mackey, Scott; Spechler, Philip A; Potter, Alexandra; Orr, Catherine; D'Alberto, Nicholas; Hudson, Kelsey E; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Higgins, Stephen T; Schumann, Gunter; Althoff, Robert R; Stein, Elliot A; Garavan, Hugh; IMAGEN Consortium.

In: BIOL PSYCHIAT-COGN N, Vol. 4, No. 7, 07.2019, p. 672-679.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chaarani, B, Kan, K-J, Mackey, S, Spechler, PA, Potter, A, Orr, C, D'Alberto, N, Hudson, KE, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Nees, F, Papadopoulos-Orfanos, D, Paus, T, Poustka, L, Smolka, MN, Walter, H, Whelan, R, Higgins, ST, Schumann, G, Althoff, RR, Stein, EA, Garavan, H & IMAGEN Consortium 2019, 'Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms', BIOL PSYCHIAT-COGN N, vol. 4, no. 7, pp. 672-679. https://doi.org/10.1016/j.bpsc.2019.02.006

APA

Chaarani, B., Kan, K-J., Mackey, S., Spechler, P. A., Potter, A., Orr, C., D'Alberto, N., Hudson, K. E., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., ... IMAGEN Consortium (2019). Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms. BIOL PSYCHIAT-COGN N, 4(7), 672-679. https://doi.org/10.1016/j.bpsc.2019.02.006

Vancouver

Chaarani B, Kan K-J, Mackey S, Spechler PA, Potter A, Orr C et al. Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms. BIOL PSYCHIAT-COGN N. 2019 Jul;4(7):672-679. https://doi.org/10.1016/j.bpsc.2019.02.006

Bibtex

@article{b7aed07150d746279b4044d21aa64d2d,
title = "Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms",
abstract = "BACKGROUND: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown.METHODS: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age.RESULTS: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968.CONCLUSIONS: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.",
author = "Bader Chaarani and Kees-Jan Kan and Scott Mackey and Spechler, {Philip A} and Alexandra Potter and Catherine Orr and Nicholas D'Alberto and Hudson, {Kelsey E} and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Frauke Nees and Dimitri Papadopoulos-Orfanos and Tom{\'a}{\v s} Paus and Luise Poustka and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Higgins, {Stephen T} and Gunter Schumann and Althoff, {Robert R} and Stein, {Elliot A} and Hugh Garavan and {IMAGEN Consortium}",
note = "Published by Elsevier Inc.",
year = "2019",
month = jul,
doi = "10.1016/j.bpsc.2019.02.006",
language = "English",
volume = "4",
pages = "672--679",
journal = "BIOL PSYCHIAT-COGN N",
issn = "2451-9022",
publisher = "Elsevier Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

AU - Chaarani, Bader

AU - Kan, Kees-Jan

AU - Mackey, Scott

AU - Spechler, Philip A

AU - Potter, Alexandra

AU - Orr, Catherine

AU - D'Alberto, Nicholas

AU - Hudson, Kelsey E

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Higgins, Stephen T

AU - Schumann, Gunter

AU - Althoff, Robert R

AU - Stein, Elliot A

AU - Garavan, Hugh

AU - IMAGEN Consortium

N1 - Published by Elsevier Inc.

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown.METHODS: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age.RESULTS: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968.CONCLUSIONS: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.

AB - BACKGROUND: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown.METHODS: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age.RESULTS: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968.CONCLUSIONS: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.

U2 - 10.1016/j.bpsc.2019.02.006

DO - 10.1016/j.bpsc.2019.02.006

M3 - SCORING: Journal article

C2 - 31072760

VL - 4

SP - 672

EP - 679

JO - BIOL PSYCHIAT-COGN N

JF - BIOL PSYCHIAT-COGN N

SN - 2451-9022

IS - 7

ER -